What Is Histidyl D-Tryptophanyl Dipeptide-29 D-Phenylalanyl Lysinamide?
Histidyl D-Tryptophanyl Dipeptide-29 D-Phenylalanyl Lysinamide is a lab-crafted mini protein that scientists call a peptide. It is modeled after Growth Hormone-releasing peptide 6, a short chain of amino acids first explored in medical research during the late 1980s. When researchers noticed its ability to signal skin cells to behave in a more youthful way, cosmetic chemists adapted the molecule for topical use. The peptide is produced through solid-phase peptide synthesis, a step-by-step process that links individual amino acids in a precise order then purifies the finished chain. Once made, it looks like a fine white powder that dissolves in water-based solutions. You will most often spot this ingredient in targeted anti-aging serums, firming eye creams, sheet masks, leave-on night treatments and high-performance moisturizers where brands want an extra skin-reviving boost.
Histidyl D-Tryptophanyl Dipeptide-29 D-Phenylalanyl Lysinamide’s Cosmetic Benefits/Uses
This peptide plays a single yet valuable role in skincare formulas.
As a skin-conditioning agent it helps improve the overall feel and appearance of the complexion. By encouraging better cell communication it can support smoother texture, enhanced firmness and a healthier moisture balance, leaving skin looking refreshed and more resilient.
Who Can Use Histidyl D-Tryptophanyl Dipeptide-29 D-Phenylalanyl Lysinamide
This lab-made peptide is water soluble and lightweight so it suits most skin types including dry, oily, combination, sensitive and mature skin. Because it is not occlusive or heavily acidic it rarely triggers breakouts or stinging, though people with extremely reactive skin should introduce it slowly to gauge tolerance.
The ingredient is produced through synthetic chemistry with no animal-derived starting materials, which makes it appropriate for vegans and vegetarians.
Current research has not flagged any special risks for women who are pregnant or breastfeeding, but data is limited. This information is not medical advice and anyone who is expecting or nursing should ask a healthcare provider before adding new products to their routine, just to be safe.
Histidyl D-Tryptophanyl Dipeptide-29 D-Phenylalanyl Lysinamide does not make skin more sensitive to sunlight, though daily sunscreen is still recommended for overall skin health. It layers well with moisturizers, antioxidants and gentle exfoliants and can be used morning or night.
Potential Side Effects/Adverse Reactions
Responses to topical Histidyl D-Tryptophanyl Dipeptide-29 D-Phenylalanyl Lysinamide differ from person to person. The points below list potential issues, but most users experience none of them when the ingredient is formulated correctly.
- Mild redness or warmth shortly after application
- Temporary tingling or stinging in very sensitive skin
- Localized itching or dryness if overused alongside strong actives
- Rare allergic reaction resulting in swelling or hives
If any of these effects occur, stop using the product and seek advice from a medical professional.
Comedogenic Rating
Rating: 0 / 5 – non-comedogenic. Histidyl D-Tryptophanyl Dipeptide-29 D-Phenylalanyl Lysinamide is a small, water-soluble molecule that does not leave an oily film or block pores, so it earns the lowest possible score on the comedogenic scale. Its job is to signal skin cells, not sit on the surface, which makes it an easy fit for complexions that clog easily. As such, it is generally suitable for acne-prone or breakout-prone skin. Keep in mind that overall pore-clogging potential depends on the full formula so the other ingredients in a product also matter.
Summary
Histidyl D-Tryptophanyl Dipeptide-29 D-Phenylalanyl Lysinamide is a lab-made peptide that conditions skin by boosting cell communication which can translate to smoother texture, better firmness and improved moisture balance. It is still a niche ingredient seen mostly in high-end serums and eye creams rather than everyday drugstore products, but interest is growing as brands look for gentle anti-aging actives.
Current data shows it is well tolerated for most skin types with very low risk of irritation or pore blockage. As with any new skincare addition a simple patch test is wise before full use just to be sure your skin agrees with the formula.