Human Placental Enzymes: What Is It, Cosmetic Uses, Benefits & Side Effects

Curious about this ingredient? In this article we're explaining exactly what it is and why it's used within cosmetic formulations.
Updated on: June 27, 2025
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We verify all information on this page using publicly available nomenclature standards from The Personal Care Products Council (PCPC), the European Commission's CosIng database and documentation provided directly by ingredient manufacturers. Our analysis is based on technical data from these sources to ensure accuracy and reliability.

What Is Human Placental Enzymes?

Human Placental Enzymes are a blend of proteins and active enzymes taken from placentas that are collected after normal childbirth. The placental tissue is rich in growth factors, amino acids and natural sugars that help keep skin and hair healthy. Beauty brands first explored this material in the mid-20th century when researchers noticed its high nutrient content and moisturizing ability. To make the cosmetic ingredient, placentas are carefully screened, cleaned then put through a gentle extraction process that separates the enzymes from other tissue. The resulting liquid is filtered, purified and dried into a stable powder or kept as a concentrated solution.

You will see Human Placental Enzymes in products that aim to boost radiance or softness. Common examples include sheet masks, anti-aging creams, leave-on hair conditioners, scalp tonics and specialty serums meant to revive dull or brittle strands.

Human Placental Enzymes’s Cosmetic Benefits/Uses

In formulas, this ingredient serves more than one role

  • Hair Conditioning: The enzymes coat the hair shaft with lightweight proteins that smooth frizz, add shine and improve manageability. Over time they can help reduce breakage by reinforcing weak spots along each strand.
  • Skin Conditioning: On the skin, the blend of amino acids and sugars draws in water and supports the surface barrier. This leaves the complexion feeling softer, looking plumper and appearing more even in tone.

Who Can Use Human Placental Enzymes

This ingredient is generally well tolerated by normal, dry, oily and combination skin because its proteins and sugars are moisturizing yet lightweight. Very sensitive or reactive skin types should tread carefully since the material is biologically complex and could trigger redness or itching in rare cases.

As a human-derived substance it is not suitable for vegans or vegetarians seeking strictly plant or synthetic formulas. Some users may also avoid it for personal, ethical or religious reasons.

Pregnant or breastfeeding people sometimes look for extra nourishment in their routines, but data on topical use during this period is limited. This information is not medical advice; anyone expecting or nursing should double-check any product containing placental extracts with a qualified healthcare provider before use.

The enzymes themselves do not make the skin more sensitive to sunlight, so there is no special need for extra sun protection beyond a regular daily sunscreen.

Potential Side Effects/Adverse Reactions

Responses to Human Placental Enzymes differ from person to person. The points below outline potential side effects, yet most users will not experience them when the ingredient is included at standard cosmetic levels and manufactured under proper safety controls.

  • Localized redness or irritation, especially on very sensitive skin
  • Itching or stinging immediately after application
  • Allergic contact dermatitis in people with specific protein sensitivities
  • Folliculitis or small pimples if the formula is too rich for an oily complexion
  • Infection risk if applied to broken skin due to its biologic origin

If any persistent discomfort or adverse reaction occurs stop using the product and seek guidance from a healthcare professional.

Comedogenic Rating

Rating: 1 out of 5. Human Placental Enzymes are mostly made up of water-soluble proteins, amino acids and sugars that do not leave a heavy oily film on skin, so they have a very low tendency to block pores. Any comedogenic risk comes from the overall formula rather than the enzymes themselves. For that reason the ingredient is generally acceptable for people who struggle with acne or frequent breakouts. As with any biologically derived material, freshness and proper preservation are key to preventing microbial contamination that could indirectly aggravate troubled skin.

Summary

Human Placental Enzymes work as both a skin and hair conditioner. On hair the lightweight proteins cling to the cuticle to smooth frizz, add shine and reinforce weak areas which can cut down on breakage. On skin the amino acids and natural sugars pull in moisture and bolster the surface barrier so the complexion feels softer looks plumper and appears more even.

Despite these benefits the ingredient remains a niche player in today’s beauty market because sourcing is limited regulations are strict and some shoppers have ethical reservations. You will mostly find it in specialty serums masks and high-end scalp treatments rather than in everyday drugstore lines.

When processed and preserved correctly Human Placental Enzymes are considered safe for topical use with only a small chance of irritation or allergic reaction. Still it is wise to try any new product on a small patch of skin first so you can be sure it agrees with you before applying it more broadly.

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