Human Umbilical Serum Extract: What Is It, Cosmetic Uses, Benefits & Side Effects

Curious about this ingredient? In this article we're explaining exactly what it is and why it's used within cosmetic formulations.
Updated on: June 27, 2025
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We verify all information on this page using publicly available nomenclature standards from The Personal Care Products Council (PCPC), the European Commission's CosIng database and documentation provided directly by ingredient manufacturers. Our analysis is based on technical data from these sources to ensure accuracy and reliability.

What Is Human Umbilical Serum Extract?

Human Umbilical Serum Extract is a skin care ingredient obtained from the liquid part of blood in donated human umbilical cords. This serum is naturally rich in proteins, amino acids, sugars and growth factors that help keep skin cells hydrated and comfortable. Researchers first noticed its skin friendly qualities in medical burn care, and cosmetic chemists later adapted it for beauty products when they saw its strong moisturizing power.

The process starts with ethically sourced umbilical cords collected under strict medical guidelines and screened for safety. The serum is separated by gentle centrifugation, then purified and filtered to remove any unwanted cells or debris. Finally it is stabilized so it can blend smoothly into creams and serums without losing potency.

You will most often see Human Umbilical Serum Extract in high end moisturizers, sheet masks, anti aging serums and intensive night creams. Brands add it to products aimed at boosting moisture, soothing dryness and giving skin a fresh plump look.

Human Umbilical Serum Extract’s Cosmetic Benefits/Uses

This extract lends two key actions to a formula, each helping skin look and feel better.

  • Humectant: Pulls water from the air and deeper skin layers to the surface, keeping skin hydrated for longer. This can make fine lines look softer and give skin a dewy finish.
  • Emollient: Smooths the skin surface by filling tiny gaps between dry cells, which leaves skin feeling silky and comfortable while improving the spreadability of a product.

Who Can Use Human Umbilical Serum Extract

Thanks to its gentle humectant and emollient nature, Human Umbilical Serum Extract is generally suitable for most skin types. Dry or mature skin may see the biggest boost because the ingredient excels at pulling in moisture and softening rough spots. Normal and combination skin can also benefit without feeling weighed down since the extract absorbs quickly. Very oily or acne prone skin might find the rich texture of some formulas too occlusive, so lightweight products are the better choice in that case.

Because the extract is sourced from donated human tissue, it is not considered vegan or vegetarian friendly. Those who follow plant based lifestyles or avoid animal derived ingredients for ethical or personal reasons will want to steer clear.

Current research has not flagged any special concerns for pregnant or breastfeeding women when the ingredient is used topically, but safety data is still limited. This is not medical advice and anyone who is expecting or nursing should run any new skincare product past a healthcare professional just to be safe.

The extract does not increase photosensitivity, so it will not make skin more prone to sunburn. Standard daily sunscreen is still recommended for overall skin health.

Products using Human Umbilical Serum Extract must meet strict screening and purification standards, so reputable brands will clearly state that the material was ethically sourced and tested for safety before it reaches the shelf.

Potential Side Effects/Adverse Reactions

Side effects and reactions to topical Human Umbilical Serum Extract can vary from person to person. The points below outline potential issues to be aware of, but they are uncommon when the ingredient is formulated and used correctly.

  • Mild redness or warmth
  • Itching or mild irritation in sensitive skin
  • Allergic reaction in individuals with specific protein sensitivities
  • Congestion or breakouts if used in a very rich formula on oily acne prone skin

If any discomfort or adverse reaction occurs, discontinue use and consult a healthcare professional for guidance.

Comedogenic Rating

Rating: 1 / 5

Human Umbilical Serum Extract is mostly water soluble and contains lightweight proteins and sugars rather than heavy oils or waxes, so it has very little tendency to block pores. In most formulations it sits near the skin surface as a hydrating film that draws in moisture rather than sinking deeply into follicles where clogs form. A rating of 1 reflects this low clogging risk while allowing for the fact that the final product may pair the extract with richer emollients that could affect some users.

Suitable for acne-prone or breakout-prone skin in lightweight or gel-based products.

If you are using a thick balm or cream that happens to include this extract, keep in mind it is the heavier base oils rather than the extract itself that may raise the clogging potential.

Summary

Human Umbilical Serum Extract acts as a humectant and an emollient. Its naturally occurring amino acids and sugars pull water toward the surface so skin stays plump while its silky proteins smooth tiny rough spots for a softer feel. Together these actions support a hydrated, comfortable complexion.

The ingredient remains a niche choice found mainly in high-end moisturizers and spa-level treatments. Limited supply, ethical sourcing requirements and higher production costs keep it from appearing in mass market lines.

Current data shows it is generally safe when properly purified and used topically, with only rare reports of irritation or allergy. As with any new skincare ingredient, patch testing a small area first is a sensible step to rule out personal sensitivities.

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