Hydrolyzed Red Blood Cells: What Is It, Cosmetic Uses, Benefits & Side Effects

Curious about this ingredient? In this article we're explaining exactly what it is and why it's used within cosmetic formulations.
Updated on: June 27, 2025
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We verify all information on this page using publicly available nomenclature standards from The Personal Care Products Council (PCPC), the European Commission's CosIng database and documentation provided directly by ingredient manufacturers. Our analysis is based on technical data from these sources to ensure accuracy and reliability.

What Is Hydrolyzed Red Blood Cells?

Hydrolyzed Red Blood Cells is an animal derived ingredient made by breaking down red blood cells into smaller peptides and amino acids through acid or enzyme hydrolysis. This process keeps the useful proteins while removing most of the cellular material that could cause irritation. First explored in the mid-20th century for wound care ointments, these protein fragments found their way into skincare when formulators noticed their ability to soften and smooth the surface of the skin. Today the ingredient is produced in tightly controlled facilities that collect animal blood from the meat industry, separate the red cells, then run them through a hydrolysis tank followed by filtration and drying. The final powder or liquid is water soluble and has a light pink or tan tint. You will mostly see Hydrolyzed Red Blood Cells in hydrating sheet masks, rich facial creams, anti-aging serums and specialty treatments aimed at improving skin texture and elasticity.

Hydrolyzed Red Blood Cells’s Cosmetic Benefits/Uses

In cosmetics Hydrolyzed Red Blood Cells is valued for its key role as a skin conditioning agent. The short chains of amino acids draw moisture to the skin and help hold it there, giving formulas a noticeable softening effect. These peptides can also form a light film on the surface that leaves skin feeling silky and more supple which in turn can make fine lines appear less pronounced.

Who Can Use Hydrolyzed Red Blood Cells

This ingredient is generally suitable for normal, dry and mature skin types because its small peptides excel at moisture retention and skin softening. Oily or acne-prone skin can also tolerate it since it is lightweight and water soluble, though anyone dealing with frequent breakouts may prefer oil-free formulas to keep pore congestion in check. Sensitive skin users should proceed with a bit more caution because the material is animal derived and trace proteins could spark irritation in extremely reactive complexions.

Hydrolyzed Red Blood Cells is not appropriate for vegans or vegetarians. It is sourced from animal blood collected as a by-product of the meat industry so it conflicts with plant-based or cruelty-free lifestyles.

Current data shows no specific risks for pregnant or breastfeeding women when the ingredient is used topically at the low levels found in cosmetics. Still this is not medical advice and anyone who is expecting or nursing should ask their healthcare provider before adding new skincare products just to be safe.

The ingredient does not make skin more sensitive to sunlight and can be used day or night without increasing the risk of sunburn. Because it is water soluble it layers well under sunscreens, makeup and other actives without pilling.

Potential Side Effects/Adverse Reactions

Reactions to Hydrolyzed Red Blood Cells vary from person to person. The points below outline potential side effects, but most users will not experience these issues when the ingredient is formulated and used correctly.

  • Allergic contact dermatitis causing redness itching or swelling
  • Mild stinging or burning on very sensitive or compromised skin
  • Breakouts in individuals highly prone to fungal or bacterial acne if the formula is excessively rich
  • Discomfort for users with ethical or psychological aversion to animal derived ingredients
  • Theoretical risk of infection if applied to open wounds or broken skin due to improper manufacturing or contamination

If you notice any irritation or unusual reaction stop using the product and consult a qualified healthcare professional.

Comedogenic Rating

Rating: 0‒1. Hydrolyzed Red Blood Cells is made up of small water-soluble peptides and amino acids that rinse clean from the skin and leave no heavy residue that could block pores. It contains no oils or waxes and is typically used at low concentrations, so the likelihood of clogging follicles is minimal.

Suitable for acne-prone or breakout-prone skin in most cases.

The only time pore issues might arise is if the ingredient is delivered in an overly rich cream packed with occlusive emollients. In that situation the rest of the formula, not the peptides themselves, would be the culprit.

Summary

Hydrolyzed Red Blood Cells works primarily as a skin conditioning agent. Its short chains of amino acids attract water into the upper layers of skin, boost softness and create a light breathable film that leaves the surface feeling silky and looking smoother.

Although effective, the ingredient is not as mainstream as plant-derived proteins or synthetic peptides because sourcing from animal blood limits its appeal for many brands and consumers. You will mainly spot it in specialty masks or high-end creams that target dryness and texture.

Topical use is generally considered safe at the low levels found in cosmetics, with rare instances of irritation or allergy. As with any new skincare product, patch test first to make sure your skin agrees before applying it to your whole face.

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