Hydroxyethyl Hydroxypropyl C12-15 Alkoxypropylamine Oxide: What Is It, Cosmetic Uses, Benefits & Side Effects

Curious about this ingredient? In this article we're explaining exactly what it is and why it's used within cosmetic formulations.
Updated on: June 27, 2025
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We verify all information on this page using publicly available nomenclature standards from The Personal Care Products Council (PCPC), the European Commission's CosIng database and documentation provided directly by ingredient manufacturers. Our analysis is based on technical data from these sources to ensure accuracy and reliability.

What Is Hydroxyethyl Hydroxypropyl C12-15 Alkoxypropylamine Oxide?

Hydroxyethyl Hydroxypropyl C12-15 Alkoxypropylamine Oxide is a specialty surfactant created for personal care products. Chemically it belongs to the amine oxide family, meaning it carries both water-loving and oil-loving parts that help mix oil, dirt and water. The “C12-15” part of the name points to the length of the fatty alcohol chain that comes from natural plant oils such as coconut or palm. To make the ingredient, manufacturers start with these fatty alcohols, react them with propylene oxide to build the alkoxy chain, then add hydroxyethyl and hydroxypropyl groups before finally converting the amine to an amine oxide. This multi-step process yields a gentle, highly effective cleanser that also boosts foam.

The ingredient first appeared in mild baby shampoos during the 1990s as formulators searched for surfactants that clean well without stripping hair or skin. Its popularity grew as sulfate-free and low-irritation products became mainstream. Today you will find Hydroxyethyl Hydroxypropyl C12-15 Alkoxypropylamine Oxide in facial cleansers, micellar waters, body washes, bubble baths, sulfate-free shampoos, conditioning cleansers, makeup removers and even some cream-to-foam masks.

Hydroxyethyl Hydroxypropyl C12-15 Alkoxypropylamine Oxide’s Cosmetic Benefits/Uses

This multitasking surfactant adds several useful qualities to modern formulas:

  • Cleansing: Lifts away dirt, excess oil and product buildup while remaining gentle enough for daily use on skin and hair
  • Hair conditioning: Leaves a soft, smooth feel and helps reduce static because the slightly positive charge of the amine oxide is attracted to negatively charged hair strands
  • Foam boosting: Increases the volume and stability of bubbles so cleansers feel richer and rinse away more easily

Who Can Use Hydroxyethyl Hydroxypropyl C12-15 Alkoxypropylamine Oxide

This ingredient is considered gentle enough for most skin types including dry, normal, oily and combination skin. Its mild nature makes it a common choice in baby formulas and products marketed for sensitive skin because it cleans without stripping the skin’s natural barrier. People with very reactive or compromised skin can usually tolerate it well but should still watch for any personal sensitivities that might arise from the finished formula.

Because the fatty chain is sourced from plant oils such as coconut or palm and no animal-derived components are necessary during production, Hydroxyethyl Hydroxypropyl C12-15 Alkoxypropylamine Oxide is generally suitable for vegans and vegetarians. As always, anyone following a strict lifestyle should confirm a brand’s overall sourcing and manufacturing policies.

Current data show no specific risks for pregnant or breastfeeding women when the ingredient is used in rinse-off or leave-on cosmetics at typical concentrations. This is not medical advice and anyone who is expecting or nursing should review their skincare routine with a healthcare professional to be on the safe side.

The molecule does not make skin more sensitive to sunlight so it is not considered photosensitising. It is also color-safe for dyed hair and compatible with most other common surfactants, allowing it to fit easily into many personal care routines.

Potential Side Effects/Adverse Reactions

Reactions to topical Hydroxyethyl Hydroxypropyl C12-15 Alkoxypropylamine Oxide differ from person to person. The points below list potential side effects that could occur even though they are uncommon when the ingredient is used correctly in a finished product.

  • Mild eye irritation if the raw surfactant or a highly concentrated formula gets into the eyes
  • Transient skin stinging or redness in people with very sensitive or damaged skin barriers
  • Contact dermatitis in rare cases of true allergy to amine oxides or other formula components
  • Dryness or tightness if used in a high-foaming cleanser without enough moisturising agents

If any irritation or other negative effect is noticed stop using the product and consult a healthcare professional if symptoms persist

Comedogenic Rating

Rating: 0 / 5 (non-comedogenic)

Hydroxyethyl Hydroxypropyl C12-15 Alkoxypropylamine Oxide is a water-soluble surfactant with no oily or waxy residues that could clog pores. It quickly rinses away from skin, so it has virtually no opportunity to sit inside follicles and trigger blockages. Because of this profile, it is considered suitable for acne-prone or breakout-prone skin.

Although the ingredient itself is non-comedogenic, the overall formula it appears in can still affect pores. Heavy oils, silicones or butters used alongside it may change the final product’s pore-clogging potential.

Summary

Hydroxyethyl Hydroxypropyl C12-15 Alkoxypropylamine Oxide acts as a mild cleanser, foam booster and light conditioning agent. Its amphiphilic structure pulls grime and sebum into water so they wash away easily while its slight positive charge lets it smooth the cuticle of hair or leave skin feeling soft.

The ingredient is a quiet workhorse rather than a headline grabber. You will spot it in many sulfate-free shampoos, gentle face washes and baby products, yet it rarely gets called out on front labels.

Current research and industry usage show it to be low in irritation and non-comedogenic, making it safe for most people in both rinse-off and leave-on formats. As with any new cosmetic, it is wise to patch test a product first to confirm personal compatibility.

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