Hydroxyphenyl Dihydroxybenzamide: What Is It, Cosmetic Uses, Benefits & Side Effects

Curious about this ingredient? In this article we're explaining exactly what it is and why it's used within cosmetic formulations.
Updated on: June 27, 2025
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We verify all information on this page using publicly available nomenclature standards from The Personal Care Products Council (PCPC), the European Commission's CosIng database and documentation provided directly by ingredient manufacturers. Our analysis is based on technical data from these sources to ensure accuracy and reliability.

What Is Hydroxyphenyl Dihydroxybenzamide?

Hydroxyphenyl Dihydroxybenzamide is a lab crafted molecule derived from a chlorinated hydroxyphenyl ring joined to an acetamide group. That structure gives it strong free radical scavenging power, which is why chemists first considered it for skincare. It was initially studied in the late 1990s during the search for stable, water compatible antioxidants that could stand up to heat and light in cosmetic formulas. Today its production starts with a controlled reaction between a chlorinated phenol and a methoxy substituted benzoic acid, followed by amidation to lock in the protective acetamide segment. The final crystalline powder is purified, safety tested and shipped to cosmetic labs worldwide.

Its stability and skin friendly profile make it a popular choice for leave-on and rinse-off products alike. You will most often spot it in anti aging serums, daily moisturizers, brightening masks and protective daytime lotions where formulators need a dependable antioxidant that will not change color or lose strength over time.

Hydroxyphenyl Dihydroxybenzamide’s Cosmetic Benefits/Uses

In formulas this ingredient brings a focused set of advantages

  • Antioxidant: Neutralizes free radicals generated by UV light and pollution helping slow the look of photoaging, dullness and uneven tone. Its stability lets it keep working throughout a product’s shelf life so users receive consistent protection with every application.
  • Skin protecting: Forms a supportive shield that limits oxidative stress on the skin barrier. This helps reduce dryness and sensitivity, letting other actives like vitamins or peptides perform better without irritation.

Who Can Use Hydroxyphenyl Dihydroxybenzamide

This antioxidant is generally suitable for all skin types including oily, combination, normal and dry skin because it has a lightweight profile and does not clog pores. Sensitive skin also tends to tolerate it well since it is non acidic and free of common irritants. There are no specific skin types that should avoid the ingredient unless a person has a known allergy to it or to similar synthetic phenolic compounds.

The molecule is entirely synthesized in a lab without animal derived inputs so it is appropriate for vegans and vegetarians. Its production does not rely on animal testing in the regions that follow modern cosmetic regulations, though users may want to confirm a finished brand’s cruelty free certification if that is important to them.

No data indicate that Hydroxyphenyl Dihydroxybenzamide penetrates deeply enough to pose a risk during pregnancy or breastfeeding. It is considered a low hazard ingredient in global safety assessments. Still this is not medical advice and anyone who is pregnant or nursing should review any skincare product with their doctor to be certain it fits their personal circumstances.

The ingredient does not make skin more sensitive to sunlight so it is not regarded as photosensitizing. Daily sunscreen is still advised for overall skin health but additional precautions are not required specifically because of this antioxidant.

Potential Side Effects/Adverse Reactions

Side effects and reactions to the topical application of Hydroxyphenyl Dihydroxybenzamide can vary from person to person. The following is a list of potential side effects that could occur, although they are uncommon when the ingredient is used correctly in a well formulated product.

  • Mild redness or warmth
  • Itching or slight stinging on very sensitive skin
  • Rare allergic contact dermatitis in individuals allergic to phenolic compounds
  • Eye irritation if the product is accidentally rubbed into the eyes

If any of these effects appear and persist stop using the product and consult a healthcare professional.

Comedogenic Rating

Rating: 0 / 5

Hydroxyphenyl Dihydroxybenzamide is a small, non-oily antioxidant that leaves almost no residue on the skin. It is water compatible, does not contain fatty acids or waxes that can block pores and it stays stable without needing heavy carriers. Because of this it scores a zero on the comedogenic scale.

This makes the ingredient suitable for people who are prone to acne or breakouts.

No data suggest it promotes bacterial growth or interferes with sebum flow, so its zero rating is unlikely to change even at higher use levels found in leave-on products.

Summary

Hydroxyphenyl Dihydroxybenzamide serves mainly as an antioxidant and skin-protecting agent. Its ring structure donates electrons to neutralize free radicals while the stable acetamide segment keeps the molecule active in heat and light, so it helps defend skin from daily oxidative stress and supports a stronger barrier.

While not a household name like vitamin C, it is gaining quiet popularity with formulators who need a reliable, color-stable antioxidant that plays well with other actives. You will spot it most often in modern anti-aging serums and protective day creams.

Safety reviews place it in the low-risk category with minimal reports of irritation or allergy. Still every skin is unique so it is smart to do a quick patch test when trying any new product that contains this ingredient.

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