Isophorone Diamine/Isophthalic Acid/Tromethamine Copolymer: What Is It, Cosmetic Uses, Benefits & Side Effects

Curious about this ingredient? In this article we're explaining exactly what it is and why it's used within cosmetic formulations.
Updated on: June 30, 2025
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We verify all information on this page using publicly available nomenclature standards from The Personal Care Products Council (PCPC), the European Commission's CosIng database and documentation provided directly by ingredient manufacturers. Our analysis is based on technical data from these sources to ensure accuracy and reliability.

What Is Isophorone Diamine/Isophthalic Acid/Tromethamine Copolymer?

Isophorone Diamine/Isophthalic Acid/Tromethamine Copolymer is a man-made ingredient created by linking three smaller molecules— isophorone diamine, isophthalic acid and tromethamine— into a long repeating chain. The result is a stable, flexible polymer that works well in water-based and water-free formulations. All three building blocks are produced through standard petrochemical processes, giving the final copolymer a consistent quality that is hard to achieve with natural raw materials.

The cosmetic world first took notice of this polymer in the early 2000s when formulators were seeking lightweight, non-tacky film formers that could boost the staying power of color products without relying on traditional resins. By adjusting the ratio of the three monomers chemists discovered that they could tailor the copolymer’s solubility and feel, making it attractive for modern skin and hair products.

Manufacturing starts with controlled heating of isophorone diamine and isophthalic acid, which react to form amide bonds. Tromethamine is then added to balance the charge and help cap the polymer chain. The mixture is purified, neutralized and spray-dried or supplied as a concentrated solution, ready for the lab.

You will most often see Isophorone Diamine/Isophthalic Acid/Tromethamine Copolymer in long-wear makeup, smudge-proof eyeliners, waterproof mascaras, transfer-resistant foundations, lightweight hair styling creams and leave-on conditioners. Its versatility also makes it useful in facial masks, anti-aging serums and high-performance sunscreens where a flexible yet durable film is needed.

Isophorone Diamine/Isophthalic Acid/Tromethamine Copolymer’s Cosmetic Benefits/Uses

In formulas this ingredient serves one main purpose that delivers several visible advantages.

Binding: The copolymer binds pigments, powders and oils together so the finished product forms an even, long-lasting film on skin or hair. This improves wear time, reduces flaking and helps resist water, sweat and sebum without adding heaviness or stickiness.

Who Can Use Isophorone Diamine/Isophthalic Acid/Tromethamine Copolymer

This film-forming binder is considered suitable for most skin and hair types because it is lightweight and non-occlusive. Oily and combination skin appreciate its low tack finish while dry or mature skin benefits from the flexible film that helps lock in moisture from the rest of the formula. Sensitive skin generally tolerates it well since the polymer is large and does not easily penetrate, though anyone highly reactive to synthetic resins should proceed cautiously.

The ingredient is produced entirely from petrochemical feedstocks with no animal-derived substances or processing aids so it aligns with vegan and vegetarian values.

No data point to reproductive toxicity or endocrine disruption, meaning products containing this copolymer are not automatically off-limits during pregnancy or breastfeeding. That said this information is educational only; anyone expecting or nursing should run all personal-care products past a qualified health professional to be safe.

Isophorone Diamine/Isophthalic Acid/Tromethamine Copolymer does not absorb UV light and is not known to cause photosensitivity. It also plays nicely with most other common cosmetic ingredients, making formulation conflicts uncommon.

Potential Side Effects/Adverse Reactions

Individual responses to topical ingredients vary. The effects listed below are possible yet unlikely for the average user when the product is manufactured and used as directed.

  • Mild skin irritation such as redness or itching, especially on compromised or freshly exfoliated skin
  • Allergic contact dermatitis in people already sensitized to amine-based polymers
  • Temporary eye stinging if the product accidentally enters the eye area before setting
  • Transient scalp or respiratory irritation if large amounts of the dry polymer are inhaled during professional salon use

If any adverse effect occurs stop using the product immediately and consult a healthcare professional.

Comedogenic Rating

Rating: 1/5

Isophorone Diamine/Isophthalic Acid/Tromethamine Copolymer forms a breathable film that sits on the surface of skin rather than sinking into pores so it has very little tendency to trap oil or debris. Its lightweight non-occlusive nature keeps pore blockage risk low which is why it receives a rating of 1 rather than a perfect 0. Anyone prone to acne or breakouts can generally use products containing this polymer without added concern.

No data show the polymer aggravates fungal acne and it does not interfere with common acne treatments such as salicylic acid or benzoyl peroxide.

Summary

Isophorone Diamine/Isophthalic Acid/Tromethamine Copolymer is primarily a binder that locks pigments powders and oils into a smooth flexible film. This film boosts wear time makes products resistant to water sweat and sebum and keeps textures lightweight and non-sticky. Because it performs these tasks without adding bulk it has become popular in long-wear makeup waterproof mascara and modern hair styling creams though it is still considered a specialty ingredient rather than a mass-market staple.

Current safety assessments find it non-sensitizing non-phototoxic and free of reproductive or endocrine concerns when used at typical cosmetic levels. While the risk profile is low it is always smart to patch test any new product to confirm personal compatibility.

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