What Is Isopropyl Cloprostenate?
Isopropyl Cloprostenate is a lab-made ingredient designed to mimic certain effects of natural prostaglandins, a group of lipid compounds produced by the body. Chemists create it through a multi-step synthesis that links a prostaglandin-like backbone to an isopropyl ester, giving the molecule better stability and skin compatibility for topical use. First explored by pharmaceutical researchers in the 1990s, it caught the attention of the beauty industry when studies showed that prostaglandin analogues could encourage fuller lashes and brows. Cosmetic formulators soon adopted Isopropyl Cloprostenate as a gentler alternative to prescription lash enhancers, incorporating it into over-the-counter products starting in the mid-2000s.
Today you will most often see this ingredient in lash and brow conditioning serums, specialty mascaras that promise longer-looking lashes, targeted scalp serums aimed at improving hair density, and some high-performance leave-in treatments for brittle or thinning hair. Because it is potent in very low concentrations, it typically appears toward the end of an ingredient list.
Isopropyl Cloprostenate’s Cosmetic Benefits/Uses
In cosmetics Isopropyl Cloprostenate serves a single key role: hair conditioning. By supporting the natural growth cycle of hair fibers it helps lashes, brows and scalp hair look denser, stronger and more flexible. Regular use in a serum or mascara base can give the appearance of increased length and fullness, while also reducing the look of breakage at the tips.
Who Can Use Isopropyl Cloprostenate
Because it is used in very small amounts and is non-oily, Isopropyl Cloprostenate suits normal, dry, oily and combination skin types. Sensitive skin can usually tolerate it, yet people who react easily around the eye area should approach with added care because the ingredient is often applied near the lash line. It is not known to clog pores so acne-prone users are generally safe to give it a try.
The molecule is fully synthetic and contains no animal-derived materials, making it acceptable for both vegans and vegetarians.
There is little published data on topical exposure during pregnancy or breastfeeding. Out of caution, anyone who is pregnant or nursing should ask a healthcare professional before using products that contain Isopropyl Cloprostenate. This information is educational and not medical advice.
The ingredient does not increase photosensitivity, so there is no special need for extra sun protection beyond the daily SPF that dermatologists already recommend.
Potential Side Effects/Adverse Reactions
Reactions to Isopropyl Cloprostenate differ from one person to another. The points below describe potential side effects that have been reported. They are uncommon when a product is formulated and used as directed.
- Mild redness or irritation usually around the lash line or brow area
- Itching or stinging sensation shortly after application
- Eyelid skin darkening especially with prolonged use near the eyes
- Darkening of the iris more likely in light-colored eyes though very rare with cosmetic strengths
- Unwanted facial hair growth if the serum migrates to adjacent skin areas
- Dry or watery eyes when used with certain eye medications
- Raised intraocular pressure changes possible in individuals with glaucoma or ocular hypertension
If any of these effects occur stop use right away and seek advice from a medical professional.
Comedogenic Rating
Rating: 0 / 5. Isopropyl Cloprostenate is used in extremely low concentrations, has a lightweight ester structure and is not oily or occlusive, so it does not sit in pores or form a film that could trap debris. There is no clinical or anecdotal evidence linking it to pore blockage. It is therefore considered non-comedogenic and suitable for people who are prone to acne or breakouts.
Because it is often paired with emollients or thickening agents in lash and brow serums, any pore-clogging risk usually comes from those companion ingredients rather than from Isopropyl Cloprostenate itself.
Summary
Isopropyl Cloprostenate is a lab-made prostaglandin analogue used in cosmetics to condition hair. By gently extending the natural growth phase of lashes brows and scalp hair it helps them appear longer fuller and stronger. Its popularity spiked with the rise of over-the-counter lash serums in the 2000s but it remains a niche ingredient found mostly in specialty eye and hair products rather than in everyday skincare.
When formulated and applied as directed it is generally safe with side effects being uncommon and mild for most users. Still everyone’s skin is unique so it is smart to patch test any new product that contains Isopropyl Cloprostenate before full use.