Isostearoyloxy Cyclohexylbutyramide: What Is It, Cosmetic Uses, Benefits & Side Effects

Curious about this ingredient? In this article we're explaining exactly what it is and why it's used within cosmetic formulations.
Updated on: June 30, 2025
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We verify all information on this page using publicly available nomenclature standards from The Personal Care Products Council (PCPC), the European Commission's CosIng database and documentation provided directly by ingredient manufacturers. Our analysis is based on technical data from these sources to ensure accuracy and reliability.

What Is Isostearoyloxy Cyclohexylbutyramide?

Isostearoyloxy Cyclohexylbutyramide is a lab crafted ester that combines isostearic acid, a fatty acid often sourced from plant oils like rapeseed or soybean, with a cyclohexylbutyramide backbone. The pairing gives the molecule its silky feel and skin friendly profile. Chemists first explored this type of ester in the early 2000s when brands wanted alternatives to heavier mineral oils and silicones. Through a straightforward esterification process, the fatty acid reacts with the amide under controlled heat and the result is a clear, low odor liquid that blends easily into creams and lotions.

You will spot Isostearoyloxy Cyclohexylbutyramide in moisturizers, nourishing masks, anti aging serums, makeup primers, tinted moisturizers and even some high SPF sunscreens. It helps these formulas glide on smoothly while leaving a soft non greasy finish.

Isostearoyloxy Cyclohexylbutyramide’s Cosmetic Benefits/Uses

This ingredient earns its place on an ingredient list thanks to two main jobs

  • Skin conditioning – It forms a light, breathable layer that smooths rough patches, helping the skin surface feel softer and more supple
  • Emollient – Its lipid like structure fills in tiny gaps between skin cells, reducing moisture loss and giving products a creamy, cushiony texture that is pleasant to spread

Who Can Use Isostearoyloxy Cyclohexylbutyramide

For most people this ester is gentle enough for daily use. Its light non greasy feel suits normal, dry and combination skin that need extra softness without heavy residue. Oily or acne prone skin can usually tolerate it as well since the molecule is lightweight and does not clog pores in standard use but extremely breakout-prone users may want to watch their skin when first trying it.

The ingredient is made from plant sourced fatty acids plus a lab crafted amide so it is generally considered vegan and vegetarian friendly. Always double check the full product label because other ingredients in the same formula could come from animals.

No research shows special risks for women who are pregnant or breastfeeding when the compound is applied topically in cosmetic amounts. This is not medical advice and anyone expecting or nursing should run any new skin care product past a doctor just to be safe.

Isostearoyloxy Cyclohexylbutyramide does not make skin more sensitive to the sun so your usual daytime sun protection routine is enough.

Potential Side Effects/Adverse Reactions

Side effects can vary from person to person. The points below outline possible reactions to Isostearoyloxy Cyclohexylbutyramide though most users will not run into these problems when the product is well made.

  • Mild redness or stinging on very sensitive or damaged skin
  • Temporary clogged pores in users who are highly prone to blackheads
  • Allergic contact dermatitis in the rare event of an individual allergy to the ester or other formula components
  • Eye irritation if the product is accidentally rubbed into the eyes

If you develop persistent irritation stop use and consult a healthcare professional or dermatologist.

Comedogenic Rating

Rating: 1 / 5

This low score reflects the ingredient’s lightweight ester structure which spreads thinly and absorbs without leaving a heavy film. While it does contain a long chain fatty component, the amide-ester bond reduces its tendency to harden inside pores compared with pure oils or waxes. Most acne-prone users can use products containing Isostearoyloxy Cyclohexylbutyramide without triggering breakouts.

As with any emollient, overall clogging potential depends on the full formula and how often it is layered with other rich products, so keep an eye on your routine if you are highly congestion-prone.

Summary

Isostearoyloxy Cyclohexylbutyramide conditions skin and acts as an emollient by mimicking the lipids that naturally sit between skin cells. It fills microscopic gaps, smooths texture and locks in moisture while giving creams and serums a silky glide.

The ingredient is still something of a niche pick found mainly in mid to high-end moisturizers and primers rather than mass market staples, yet formulators appreciate its light feel which makes it a handy alternative to heavier oils.

Current data shows it is safe for topical use with very low irritation or sensitization risk. As with any new skincare ingredient a quick patch test is a smart move before applying it widely, especially if your skin is reactive or acne-prone.

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