What Is Lauroyl Sh-Oligopeptide-33?
Lauroyl Sh-Oligopeptide-33 is a hybrid molecule created when lauric acid, a medium-chain fatty acid naturally found in coconut and palm oils, is chemically bonded to Sh-Oligopeptide-33, a short chain of amino acids produced with modern fermentation technology. The lauric portion gives the peptide a lipid tail that helps it blend into the skin’s outer layer while the peptide portion carries targeted biological activity.
Peptides gained popularity in skin care in the early 2000s for their ability to signal skin cells and support a clearer look. Formulators later discovered that attaching a fatty acid such as lauric acid could improve a peptide’s stability, skin affinity and in some cases its ability to curb excess oil and unwanted microbes. Lauroyl Sh-Oligopeptide-33 is made through an acylation step where purified lauric acid reacts with Sh-Oligopeptide-33 under controlled lab conditions, followed by filtration and drying to yield a fine, water-dispersible powder.
You will typically see this ingredient in lightweight leave-on products designed for combination or oily skin such as clarifying serums, mattifying lotions, blemish-control gels, toners, sheet masks and oil-free moisturizers. It may also appear in targeted spot treatments and post-cleansing essences aimed at keeping skin balanced and comfortable.
Lauroyl Sh-Oligopeptide-33’s Cosmetic Benefits/Uses
This multifunctional ingredient earns its place on the label for two main reasons
- Anti-Sebum – Helps regulate the look of surface oil, reduces unwanted shine throughout the day and can make pores appear less obvious, giving skin a fresher matte finish and helping makeup stay put longer
- Antimicrobial – Limits the growth of odor- or blemish-causing microorganisms on the skin’s surface, supporting a clearer complexion and adding a secondary boost to product freshness
Who Can Use Lauroyl Sh-Oligopeptide-33
This peptide-fatty acid hybrid is generally best suited for normal, combination and oily skin that struggles with excess shine or occasional breakouts. Dry or very sensitive skin can also use it, but those users may prefer to buffer it with a richer moisturizer because its oil-controlling action might feel too mattifying on already parched skin.
The ingredient is synthesized in a lab from lauric acid and a bio-fermented peptide so it contains no animal-derived material. That makes it compatible with vegan and vegetarian lifestyles as long as the finished formula avoids other animal ingredients.
Products containing Lauroyl Sh-Oligopeptide-33 are not known to interfere with pregnancy or breastfeeding when used topically at typical cosmetic levels. This is not medical advice and anyone who is pregnant or nursing should confirm product choices with their healthcare provider before use to stay on the safe side.
Unlike some exfoliating acids or retinoids, this ingredient does not increase photosensitivity. Standard daytime sun protection is still recommended for overall skin health.
Potential Side Effects/Adverse Reactions
Side effects from topical Lauroyl Sh-Oligopeptide-33 differ between individuals. The following is a list of potential reactions that remain uncommon when the ingredient is used at appropriate cosmetic concentrations:
- Transient stinging or warmth immediately after application
- Mild redness or flushing in very reactive skin types
- Dry or tight feeling if applied without adequate hydration
- Rare allergic contact dermatitis resulting in itch or small bumps
- Temporary increase in breakouts when first introduced as pores adjust to reduced sebum
- Interaction irritation when layered with high levels of alcohol or strong exfoliating acids
If any persistent irritation or discomfort occurs discontinue use and consult a qualified healthcare professional
Comedogenic Rating
Rating: 1/5
Lauroyl Sh-Oligopeptide-33 is used at low percentages and is designed to cut back on excess oil rather than add heavy occlusive residue. The lauric acid tail is bonded to a water-dispersible peptide, which limits the amount of free fatty acid that could block pores. Most formula testing shows little to no tendency to form comedones, earning it a low score of 1.
Because of this mild profile it is generally a good choice for skin that is prone to acne or frequent breakouts.
Keep in mind that the overall comedogenicity of any finished product depends on the complete ingredient list, texture and concentration, so the final experience may vary.
Summary
Lauroyl Sh-Oligopeptide-33 combines a mattifying fatty acid with a bioactive peptide to curb surface oil and keep blemish-causing microbes in check. By anchoring the peptide to a lauric tail the molecule slips into the upper skin layers where it helps temper sebum output and quietly fights unwelcome bacteria.
It is still a niche addition rather than a mainstream staple, but interest is rising as brands look for gentle multitaskers that suit oily and combination skin without the harsh feel of alcohol or strong acids.
Current safety data show it is well tolerated for most users with only rare reports of sensitivity. As with any new skincare ingredient it is smart to do a small patch test before diving into full-face use to confirm your skin gets along with the formula.