What Is Lauroyl Sh-Tetrapeptide-1?
Lauroyl Sh-Tetrapeptide-1 is a lab crafted peptide derivative created by attaching a lauroyl fatty acid chain to a short four amino acid sequence known as Sh-Tetrapeptide-1. The lauroyl group makes the peptide more compatible with the skin’s lipid layers, helping it blend smoothly into cosmetic bases. Peptides have been explored in skincare since the late 1990s when researchers realized that small chains of amino acids could signal the skin to look and feel healthier. By coupling the peptide with a fatty acid, formulators increased its stability and penetration, which opened the door for its use in everyday beauty products.
To make the ingredient, chemists begin with Sh-Tetrapeptide-1 produced through controlled peptide synthesis. They then react it with lauroyl chloride under precise temperature and pH conditions. The result is a hybrid molecule that offers the skin friendly qualities of both peptides and lipids.
You will most often see Lauroyl Sh-Tetrapeptide-1 in lightweight face serums, firming eye creams, anti aging moisturizers, sheet masks and leave-on treatments designed to support smoother looking skin.
Lauroyl Sh-Tetrapeptide-1’s Cosmetic Benefits/Uses
This ingredient is valued mainly for its role as a skin conditioning agent, which means it helps maintain and improve the appearance and feel of the skin. By reinforcing the skin’s natural barrier, it can leave the surface softer, more supple and better able to retain moisture, qualities that are especially important in products targeting fine lines and overall skin comfort.
Who Can Use Lauroyl Sh-Tetrapeptide-1
Lauroyl Sh-Tetrapeptide-1 is generally well tolerated by all skin types, including dry, oily, combination and sensitive skin, thanks to its lightweight texture and gentle barrier supporting action. Those with very reactive or allergy prone complexions may still want to keep an eye on the full ingredient list of any product to ensure no personal triggers are present.
The peptide is produced through laboratory synthesis and contains no animal derived materials, making it suitable for both vegans and vegetarians. As with any finished product, cruelty free status depends on the policies of the brand itself.
No specific warnings have been issued regarding use while pregnant or breastfeeding. Still, because hormonal shifts can alter skin sensitivity and because ingredient safety data is always evolving, anyone expecting or nursing should ask their healthcare provider before adding new products to their routine. This information is educational only and not a substitute for medical advice.
Lauroyl Sh-Tetrapeptide-1 does not increase photosensitivity. Daily sunscreen is still important for overall skin health but there is no extra need for sun precautions solely due to this ingredient.
Potential Side Effects/Adverse Reactions
Side effects from topical Lauroyl Sh-Tetrapeptide-1 vary from person to person. The points below outline potential reactions yet most users experience none of these issues when the ingredient is included in a properly formulated product.
- Transient redness or mild stinging immediately after application
- Localized irritation on extremely sensitive skin
- Allergic contact dermatitis presenting as itching or small bumps
- Breakouts in acne prone users if the overall formula is overly rich or occlusive
If any uncomfortable reaction develops discontinue use and seek guidance from a qualified healthcare professional.
Comedogenic Rating
Rating: 1 / 5 (low)
Lauroyl Sh-Tetrapeptide-1 carries only a small lauroyl fatty chain and is typically used at very low percentages, so it does not create the heavy, pore clogging film associated with highly comedogenic oils. The peptide portion further reduces the chance of build-up by making the molecule water compatible and easier to rinse away.
Because of this low rating the ingredient is generally considered suitable for skin that is prone to acne or breakouts.
Keep in mind that the overall comedogenic potential of a finished product depends on the entire formula, texture and how it is layered with other products.
Summary
Lauroyl Sh-Tetrapeptide-1 is a lab made peptide linked to a mild fatty acid that conditions skin by supporting its natural barrier, helping it feel soft and stay hydrated. The lauroyl tail lets the peptide slip into skin’s lipid layers while the tetrapeptide sequence provides a gentle signal that encourages a smoother looking surface.
It is still a niche ingredient rather than a mainstream staple, yet it is gaining attention in modern serums, eye creams and sheet masks aimed at fine lines and everyday skin comfort.
Current data shows it is safe for most users with a very low risk of irritation or clogged pores. As with any new cosmetic ingredient a simple patch test is a smart precaution before applying a full face product.