Lysine Octatrienoate: What Is It, Cosmetic Uses, Benefits & Side Effects

Curious about this ingredient? In this article we're explaining exactly what it is and why it's used within cosmetic formulations.
Updated on: July 1, 2025
Share:
Inside this article:

We verify all information on this page using publicly available nomenclature standards from The Personal Care Products Council (PCPC), the European Commission's CosIng database and documentation provided directly by ingredient manufacturers. Our analysis is based on technical data from these sources to ensure accuracy and reliability.

What Is Lysine Octatrienoate?

Lysine Octatrienoate is a salt created when lysine, a naturally occurring amino acid, is combined with octatrienoic acid, an unsaturated fatty acid. The pairing gives the ingredient a balanced profile: lysine attracts water while the fatty portion offers light, oil-like protection. First explored by cosmetic chemists looking for gentler alternatives to heavy occlusives, it found its way into skin care labs in the early 2000s. Today it is made through a controlled reaction that binds purified lysine with plant-derived octatrienoic acid under mild heat, then refined into a fine powder or liquid concentrate.

Its unique mix of water-friendly and oil-friendly parts lets it sit comfortably on the skin surface without feeling greasy. Because of this, formulators add it to lightweight moisturizers, soothing masks, daily anti-aging creams and after-sun treatments where they want a protective veil that does not clog pores or leave shine.

Lysine Octatrienoate’s Cosmetic Benefits/Uses

In skin care formulas Lysine Octatrienoate serves one main purpose that brings several visible perks.

Skin protecting: When applied, the ingredient forms a soft breathable layer that helps shield the skin from moisture loss and everyday irritants. This gentle barrier supports a smoother feel, keeps dryness at bay and can calm the look of redness triggered by environmental stress. Regular use may leave the complexion appearing more resilient and comfortably hydrated.

Who Can Use Lysine Octatrienoate

Lysine Octatrienoate is considered gentle enough for most skin types including dry, normal, combination, oily and even sensitive complexions because it forms a lightweight protective film that lets skin breathe. People with very severe acne or active pustular breakouts might prefer to introduce it slowly since any lipid-based additive could feel too rich during an active flare, though the ingredient itself is rated low for pore clogging.

The lysine portion is typically produced by microbial fermentation and the octatrienoic acid is sourced from plant oils, making the final salt suitable for vegans and vegetarians when the finished product is manufactured along the same animal-free lines.

No data point to hormonal or systemic effects, so pregnant or breastfeeding women can generally use products containing Lysine Octatrienoate; however this is not medical advice and anyone who is expecting or nursing should review their skincare routine with a physician to be certain.

The molecule does not absorb UV light and is not known to increase photosensitivity. Normal daily sun protection is still recommended as part of any skincare routine.

Potential Side Effects/Adverse Reactions

Individual responses to topical Lysine Octatrienoate can vary. The following list covers potential side effects that have been reported or are theoretically possible yet are unlikely for most users when the ingredient is properly formulated and applied.

  • Mild redness or warmth a short-lived flush that usually settles as skin adjusts
  • Transient stinging most often noticed on compromised or freshly exfoliated skin
  • Contact dermatitis rare allergic response presenting as itching scaling or small bumps
  • Eye irritation if the product migrates into the eye area
  • Breakout worsening uncommon clogging or papules in those extremely prone to acne

If any persistent or severe reaction occurs stop using the product and consult a qualified healthcare professional.

Comedogenic Rating

Rating: 1 / 5

Lysine Octatrienoate earns a low score because its salt structure is lightweight and water compatible, so it does not behave like heavier oils or waxes that can block pores. The molecule forms a thin breathable film that sits on the skin surface without trapping excess sebum or dead cells. A small fatty acid portion is present which is why the rating is not zero, yet real-world testing and user feedback show minimal clogging potential.

Most people prone to acne or breakouts should find Lysine Octatrienoate acceptable in leave-on products, especially when used in well balanced formulas that avoid heavy comedogenic partners.

Formulation matters: if the ingredient is combined with richer butters or high-viscosity silicones the overall product could still feel too occlusive, so the finished formula’s texture is what ultimately determines breakout risk.

Summary

Lysine Octatrienoate acts chiefly as a skin protector. By marrying water loving lysine with a flexible unsaturated fatty acid, it creates a salt that lightly coats the surface, reduces moisture loss, softens rough patches and helps calm visible redness from environmental stress. This gentle barrier effect promotes hydration comfort and resilience without a greasy afterfeel.

The ingredient is still something of a niche pick. You will spot it in a handful of modern moisturizers, soothing after-sun gels and lightweight barrier creams, but it has not yet reached the mainstream popularity of classics like glycerin or hyaluronic acid.

Safety data are reassuring: irritations are uncommon, allergic reactions are rare and no systemic concerns have been noted. As with any new skincare addition it is wise to patch test a product containing Lysine Octatrienoate, watch for any unwanted response and proceed accordingly.

Was this article helpful?
More from Glooshi:
ADVERTISEMENT
Get all our top headlines in beauty.
Delivered right to your inbox each week. Zero spam, all goodness, opt-out at anytime.
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
Get the latest beauty news, top product recommendations & brand-exclusive discount codes direct to your inbox.
Send good feedback:

All feedback is greatly appreciated, anonymous, and will be used to improve the quality of our articles.

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
Send bad feedback:

All feedback is greatly appreciated, anonymous, and will be used to improve the quality of our articles.

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
Search