Menthane Carboxamidoethyl Acetate: What Is It, Cosmetic Uses, Benefits & Side Effects

Curious about this ingredient? In this article we're explaining exactly what it is and why it's used within cosmetic formulations.
Updated on: July 1, 2025
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We verify all information on this page using publicly available nomenclature standards from The Personal Care Products Council (PCPC), the European Commission's CosIng database and documentation provided directly by ingredient manufacturers. Our analysis is based on technical data from these sources to ensure accuracy and reliability.

What Is Menthane Carboxamidoethyl Acetate?

Menthane Carboxamidoethyl Acetate is a lab made derivative of menthane, the cooling compound found in mint plants. Chemically identified as ethyl N-((5-methyl-2-isopropyl)cyclohexyl)carbonyl)glycinate, it pairs part of the menthol structure with a small amino acid and an acetate group. This tweak keeps the familiar fresh sensation of mint while making the molecule more stable and skin friendly.

The ingredient was first explored in the late 1990s when formulators looked for cooling agents that would not irritate skin the way straight menthol sometimes can. By adding the carboxamidoethyl and acetate portions, chemists created a gentler compound that still gives a pleasant refreshing feel. Since then it has been adopted by cosmetic brands aiming to add a mild cooling touch to skincare without the sting.

Production starts with synthetic menthane made from citronellal or other terpene sources. The menthane core is reacted with carbonyl chloride to introduce a carbonyl group. It is then coupled with glycine ethyl ester and finally acetylated, yielding a crystalline powder that dissolves well in oils or alcohol. All steps occur in closed reactors under food grade or cosmetic grade regulations.

You will most often spot Menthane Carboxamidoethyl Acetate in products that promise a fresh or soothing feel. It appears in sheet masks, after-sun gels, moisturizers for oily skin, shave balms, eye creams and certain scalp treatments. Formulators like it because a small amount delivers a lasting cooling effect while doubling as a skin conditioning agent that helps products feel silky.

Menthane Carboxamidoethyl Acetate’s Cosmetic Benefits/Uses

This ingredient is valued for the way it makes skin feel as well as for the subtle improvements it brings to a formula’s texture.

Skin conditioning: Menthane Carboxamidoethyl Acetate sits on the surface of the skin forming a light, breathable film that helps soften and smooth. It can leave a soft touch finish that reduces roughness and boosts overall comfort while the gentle cooling sensation adds a pleasant user experience.

Who Can Use Menthane Carboxamidoethyl Acetate

This ingredient is generally well tolerated by oily, combination and normal skin types because it is lightweight and non greasy. Dry or very sensitive skin can usually use it too although the cooling sensation may feel stronger when the skin barrier is compromised, so those with eczema or dermatitis should proceed with extra care.

Menthane Carboxamidoethyl Acetate is produced entirely from synthetic sources with no animal derived raw materials which makes it suitable for both vegetarians and vegans.

Current data does not indicate any special risks for pregnant or breastfeeding women when the ingredient is used in rinse off or leave on cosmetics at normal levels. This is not medical advice and anyone who is expecting or nursing should show the full ingredient list of a product to a qualified physician before adding it to a routine.

The molecule is not known to cause photosensitivity and does not interfere with sunscreen performance. Standard daytime sun protection habits are still recommended.

Potential Side Effects/Adverse Reactions

Reactions to topical Menthane Carboxamidoethyl Acetate differ from person to person. The points below list potential side effects that could occur even though most users will not experience them when the product is formulated and used correctly.

  • Temporary stinging or burning
  • Redness or flushing in sensitive areas
  • Contact dermatitis in individuals allergic to menthyl derivatives
  • Excessive cooling that feels uncomfortable on compromised or very dry skin
  • Eye irritation if the product accidentally migrates into the eyes
  • Rare headache or dizziness triggered by strong cooling sensation around the temples

If any of the above effects occur stop using the product at once and seek advice from a healthcare professional.

Comedogenic Rating

Rating: 1/5

Menthane Carboxamidoethyl Acetate is an airy, low viscosity molecule that sits on skin in a thin film then evaporates or wears off without clogging pores. It contains no heavy oils or waxes that can trap dead skin cells or sebum, so the chance of it creating blockages is minimal. For these reasons it earns a low comedogenic score of 1.

Because of this low rating it is generally considered suitable for people who are prone to acne or breakouts.

Formulas that pair it with richer butters or occlusive agents could alter the overall pore clogging potential of the finished product, so the full ingredient list still matters when evaluating any item marketed to acne prone skin.

Summary

Menthane Carboxamidoethyl Acetate is a lab designed menthyl derivative that conditions skin while delivering a pleasant, lasting cooling sensation. It smooths the surface by forming a light breathable film and boosts the sensory appeal of creams, gels or balms through its fresh touch.

The ingredient is moderately popular, showing up most often in after sun care, shave products and masks that promise instant refreshment rather than across the board in mainstream moisturizers.

Safety data to date points to a low risk of irritation for the average user with rare cases of sensitivity tied mainly to overuse on compromised skin. As with any new cosmetic it is wise to perform a small patch test before full application to be on the safe side.

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