What Is Methionyl Sh-Oligopeptide-1 Sr-Jellyfish Polypeptide-1?
Methionyl Sh-Oligopeptide-1 Sr-Jellyfish Polypeptide-1 is a lab-crafted fusion peptide that combines elements of human epidermal growth factor–like Sh-Oligopeptide-1 with a protein segment found in certain jellyfish, and starts with the amino acid methionine. Scientists create the gene that codes for this 292-amino-acid chain then insert it into a strain of E. coli. During controlled fermentation the bacteria produce large amounts of the peptide, which is later purified, filtered and blended into cosmetic-grade solutions.
Interest in this hybrid peptide grew as brands searched for gentle bio-active alternatives to animal collagen and plant extracts. Early in-house studies showed that linking a growth factor fragment with jellyfish protein might improve stability on skin, so formulators began testing it in anti-age creams around the late 2010s. Today you can spot it in sheet masks, serums, moisturizers and targeted “age-defy” treatments that promise to shield skin from daily stress.
Methionyl Sh-Oligopeptide-1 Sr-Jellyfish Polypeptide-1’s Cosmetic Benefits/Uses
When added to a topical formula this peptide mainly serves two roles that work together to keep skin looking healthy.
- Antioxidant: Helps neutralize free radicals created by UV light and pollution which can otherwise lead to dullness and fine lines. By reducing oxidative stress the ingredient supports a more even skin tone and may slow the appearance of premature aging.
- Skin protecting: Forms a lightweight conditioning film that reinforces the skin barrier. This extra layer helps lock in moisture, shields against irritants in the environment and can enhance the comfort of sensitive or post-treatment skin.
Who Can Use Methionyl Sh-Oligopeptide-1 Sr-Jellyfish Polypeptide-1
This peptide suits most skin types including dry, normal, combination and oily since it is lightweight and non-comedogenic. Sensitive skin generally tolerates it well thanks to its barrier-supporting action, though anyone with a known allergy to fermented ingredients or bacterial proteins should stay cautious.
The ingredient is produced in a lab using E. coli fermentation without animal-derived inputs so it is appropriate for vegans and vegetarians.
Current data shows no specific risks for pregnant or breastfeeding women when the peptide is applied topically at the low percentages found in cosmetics. This is not medical advice and anyone who is expecting or nursing should discuss new skincare products with a healthcare professional to be on the safe side.
Methionyl Sh-Oligopeptide-1 Sr-Jellyfish Polypeptide-1 does not increase photosensitivity, meaning it will not make skin more prone to sunburn. Regular daytime sunscreen use is still recommended as part of a complete routine.
The peptide layers well with most common actives including niacinamide, ceramides and hyaluronic acid. Formulators usually avoid pairing it with highly acidic exfoliants above 10 percent concentration which could destabilize proteins, but this is handled in product development rather than by the end user.
Potential Side Effects/Adverse Reactions
Side effects from topical Methionyl Sh-Oligopeptide-1 Sr-Jellyfish Polypeptide-1 vary between individuals. The points below describe potential reactions that are unlikely for the average user when the ingredient is properly formulated and used as directed.
- Mild redness or warmth
- Tingling or transient stinging on very sensitive skin
- Contact dermatitis in those allergic to bacterial fermentation residues
- Rare delayed irritation when combined with high levels of strong acids or retinoids
If any discomfort, rash or persistent irritation occurs discontinue use and consult a qualified healthcare provider.
Comedogenic Rating
Rating: 0 / 5
This peptide is water soluble, lightweight and does not leave an occlusive film that could trap oil inside pores. It lacks fatty acids or heavy waxes that usually raise comedogenic potential, so it earns the lowest score.
Because it is non comedogenic it is generally suitable for people who are prone to acne or frequent breakouts.
Any clogging issues that might arise are more likely linked to other ingredients in the finished formula such as rich oils or silicones rather than to Methionyl Sh-Oligopeptide-1 Sr-Jellyfish Polypeptide-1 itself.
Summary
Methionyl Sh-Oligopeptide-1 Sr-Jellyfish Polypeptide-1 is a lab made fusion peptide that acts as an antioxidant and a skin protectant. It mops up free radicals from sun and pollution then forms a light barrier on the surface to help keep moisture in and irritants out, supporting a smoother brighter look.
Right now it is a niche addition seen mostly in premium serums and sheet masks yet interest is rising as brands look for fresh bioactive options beyond plant extracts.
Safety data so far shows the ingredient is gentle and well tolerated with only rare reports of mild irritation. As with any new skincare step users should patch test first to make sure their skin agrees with the product.