What Is Methionyl Sh-Polypeptide-7 Dipeptide-19 Sr-Spider Polypeptide-4 Hexapeptide 40?
Methionyl Sh-Polypeptide-7 Dipeptide-19 Sr-Spider Polypeptide-4 Hexapeptide 40 is a lab-designed peptide made by fermenting a customized strain of E. coli. Scientists join the genetic codes for three smaller peptides—Sh-Polypeptide-7, Dipeptide-19 and Sr-Spider Polypeptide-4—then add a methionine start signal. The bacteria read this fused gene and build a single chain of 217 amino acids using the 20 standard building blocks found in human skin proteins. After fermentation the peptide is purified, filtered and blended into cosmetic bases.
Peptide technology gained popularity in skin care in the early 2000s when brands looked for gentler, more targeted alternatives to retinoids. This particular fusion peptide is a newer entry valued for its multitasking nature. Because it mimics fragments of growth factors and silk spider proteins, formulators see it as a flexible tool for both hydration and barrier support.
You will usually spot Methionyl Sh-Polypeptide-7 Dipeptide-19 Sr-Spider Polypeptide-4 Hexapeptide 40 in lightweight serums, sheet masks, eye creams, repair concentrates, after-sun gels and anti-aging moisturizers. It blends well with humectants like glycerin or hyaluronic acid, sits comfortably under makeup and is stable in water-based systems.
Methionyl Sh-Polypeptide-7 Dipeptide-19 Sr-Spider Polypeptide-4 Hexapeptide 40’s Cosmetic Benefits/Uses
Formulators choose this peptide for its ability to play several helpful roles in one formula.
- Skin conditioning – Helps skin feel softer and look smoother by supporting natural renewal and encouraging an even surface
- Emollient – Adds a light layer of softness that reduces rough patches without a greasy finish
- Skin protecting – Reinforces the skin’s moisture barrier so it can hold water better and stay resilient against daily stress
Who Can Use Methionyl Sh-Polypeptide-7 Dipeptide-19 Sr-Spider Polypeptide-4 Hexapeptide 40
This peptide suits most skin types including normal, dry, oily and combination because it is lightweight and non occlusive. Sensitive skin generally tolerates it well thanks to its gentle, fragrance free profile, yet those with a history of allergies to ferment derived ingredients should proceed cautiously since trace fermentation by-products could provoke irritation.
Because the molecule is made through plant based bacterial fermentation and contains no animal derived materials, it is considered appropriate for both vegans and vegetarians.
Current safety data shows no known hormonal activity so products containing this ingredient are not automatically off limits for people who are pregnant or breastfeeding. That said this is not medical advice and anyone who is expecting or nursing should review any new skincare with their doctor before use to be safe.
The peptide does not make skin more sensitive to sunlight, so it does not increase the risk of sunburn. Standard daytime sun protection is still recommended but no special SPF rules apply specifically to this ingredient.
Potential Side Effects/Adverse Reactions
Responses to topical Methionyl Sh-Polypeptide-7 Dipeptide-19 Sr-Spider Polypeptide-4 Hexapeptide 40 vary from person to person. The effects listed below are uncommon and most users should not expect to experience them when the product is formulated and used correctly.
- Mild stinging or tingling on application
- Temporary redness or flushing
- Localized itching or dryness
- Allergic contact dermatitis in individuals sensitive to peptides or fermentation residues
- Interaction irritation if layered with strong exfoliating acids or high concentration retinoids
If any of these reactions occur discontinue use and consult a healthcare professional or dermatologist.
Comedogenic Rating
Rating: 0. Methionyl Sh-Polypeptide-7 Dipeptide-19 Sr-Spider Polypeptide-4 Hexapeptide 40 is a large water soluble peptide that sits on the surface of the skin then rinses away with normal cleansing so it does not lodge inside pores. It contains no oils, waxes or fatty acids that typically trigger congestion. This makes it suitable for people who are prone to acne or breakouts. Do keep in mind that the final product’s base, such as heavy butters or silicones, can change how pore friendly the overall formula feels.
Summary
Methionyl Sh-Polypeptide-7 Dipeptide-19 Sr-Spider Polypeptide-4 Hexapeptide 40 conditions skin, provides a silky emollient finish and helps reinforce the moisture barrier. It does this by mimicking tiny fragments of growth factors and spider silk peptides that encourage smoother cell turnover while forming a lightweight film that slows water loss.
Although it is not as famous as long-standing peptides like Matrixyl it is gaining traction in high end serums and sheet masks thanks to its multitasking profile and vegan friendly origin. Safety reviews show a very low irritation record and no links to hormone disruption. As with any new skincare ingredient it is smart to patch test first so you can be sure your skin agrees with it.