Methylchloroisothiazolinone: What Is It, Cosmetic Uses, Benefits & Side Effects

Curious about this ingredient? In this article we're explaining exactly what it is and why it's used within cosmetic formulations.
Updated on: July 1, 2025
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We verify all information on this page using publicly available nomenclature standards from The Personal Care Products Council (PCPC), the European Commission's CosIng database and documentation provided directly by ingredient manufacturers. Our analysis is based on technical data from these sources to ensure accuracy and reliability.

What Is Methylchloroisothiazolinone?

Methylchloroisothiazolinone, often shortened to MCI, is a synthetic preservative identified by chemists as 5-chloro-2-methyl-2H-isothiazol-3-one. It belongs to the isothiazolinone family, a group of molecules known for keeping products free of harmful microbes. Introduced in the early 1970s as an alternative to older preservatives, MCI quickly found favor because only a tiny amount is needed to stop bacteria, mold and yeast from growing in water-based formulas.

The ingredient is produced through a controlled chemical process that starts with methylisothiazolinone. Chlorine is added to the structure, the mixture is purified, then blended with water or solvents to create a stable solution ready for cosmetic labs. Because it is lab made companies can rely on consistent quality and broad-spectrum antimicrobial power.

You will spot MCI most often in rinse-off items like shampoos, conditioners, body washes and liquid hand soaps. It is also used in some leave-on products such as lotions, sunscreens, makeup removers, sheet masks and hair styling gels when a long shelf life is needed and the formula contains water.

Methylchloroisothiazolinone’s Cosmetic Benefits/Uses

As a preservative Methylchloroisothiazolinone protects cosmetic products from bacteria, yeast and mold. This helps keep the formula safe for use, maintains the product’s texture and scent, and extends its shelf life so consumers can use it with confidence until the last drop.

Who Can Use Methylchloroisothiazolinone

MCI is generally suitable for normal, oily and combination skin because it is used at very low levels and rinses away easily in most formulas. People with very sensitive, eczema-prone or broken skin may wish to avoid it since preservatives in the isothiazolinone family are a well-known trigger for contact dermatitis in susceptible individuals.

The ingredient is fully synthetic with no animal-derived components or testing requirements specific to animals, making it appropriate for vegans and vegetarians.

Regulatory agencies allow MCI in cosmetics used by the general population, including pregnant or breastfeeding women, when it is present within the approved concentration limits. Still, this is not medical advice and anyone who is pregnant or nursing should check with a healthcare provider before adding new products to a routine just to be safe.

MCI does not make skin more sensitive to sunlight so it is not considered photosensitizing. Its main job is fighting microbes rather than interacting with UV rays.

Potential Side Effects/Adverse Reactions

Reactions to topical MCI vary from person to person. The points below outline potential side effects that have been reported, but they are not the typical experience for most users when the preservative is used correctly in a finished product.

  • Allergic contact dermatitis, usually presenting as redness or a rash at the point of application
  • Itching or burning sensations on the skin
  • Swelling or blistering in severe allergy cases
  • Dryness or flaking where the product was applied
  • Eye irritation if the product accidentally gets into the eyes
  • Cross-reaction with other isothiazolinone preservatives in people already sensitized to this chemical family

If any of these effects occur stop using the product immediately and seek advice from a qualified healthcare professional.

Comedogenic Rating

Rating: 0/5

Methylchloroisothiazolinone is used in minuscule amounts, is water soluble, has no oily or waxy texture and does not stay on the skin surface long enough to block pores. For these reasons it earns a solid zero on the comedogenic scale.

Suitable for acne-prone or breakout-prone skin because it will not contribute to clogged pores.

Since the preservative is often found in rinse-off products any residue is further reduced during use, lowering the likelihood of pore congestion even more.

Summary

Methylchloroisothiazolinone is a synthetic preservative that keeps cosmetic formulas free of bacteria, mold and yeast by disrupting the cell walls of microbes so they cannot grow. It works at very low levels which helps maintain a product’s texture, scent and shelf life without affecting how the product feels on skin.

Once a go-to preservative in shampoos, body washes and lotions its popularity has dipped as brands look for alternatives that are less likely to trigger allergies, yet it still appears in many mainstream formulas thanks to its strong antimicrobial punch.

When used within legal limits it is considered safe for most people though those with very sensitive or compromised skin may react. As with any new product it is wise to patch test first to check personal tolerance.

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