Methyldibromo Glutaronitrile: What Is It, Cosmetic Uses, Benefits & Side Effects

Curious about this ingredient? In this article we're explaining exactly what it is and why it's used within cosmetic formulations.
Updated on: July 1, 2025
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We verify all information on this page using publicly available nomenclature standards from The Personal Care Products Council (PCPC), the European Commission's CosIng database and documentation provided directly by ingredient manufacturers. Our analysis is based on technical data from these sources to ensure accuracy and reliability.

What Is Methyldibromo Glutaronitrile?

Methyldibromo glutaronitrile is a lab made molecule whose chemical name is 2-bromo-2-(bromomethyl)pentanedinitrile. In simple terms it is a small compound that carries two bromine atoms and two nitrile groups. It does not come from plants or animals but is produced through controlled chemical reactions that attach bromine to a base structure called glutaronitrile. The ingredient was introduced to cosmetics in the 1980s when chemists were searching for efficient preservatives that could work in water-based lotions and creams at very low amounts. Because it fights off bacteria and mold even in tough conditions it quickly became popular in many personal care lines.

The manufacturing process starts with glutaronitrile, which is reacted with formaldehyde and hydrobromic acid. This adds the bromine atoms and creates the final form used in products. The finished powder or liquid concentrate is then blended into cosmetic formulas during production.

You will most often spot methyldibromo glutaronitrile in rinse-off products such as shampoos, conditioners and body washes. It can also appear in leave-on items like moisturizers, sunscreens, wet wipes and makeup removers, especially those stored in jars or squeeze tubes where fingers might introduce germs.

Methyldibromo Glutaronitrile’s Cosmetic Benefits/Uses

Methyldibromo glutaronitrile serves one main purpose in cosmetics: it is a preservative. By stopping the growth of bacteria yeast and mold it keeps creams and liquids safe and fresh for their full shelf life. This helps prevent changes in smell color or texture and most importantly reduces the risk of skin irritation that can happen when a product becomes contaminated.

Who Can Use Methyldibromo Glutaronitrile

Products preserved with methyldibromo glutaronitrile are generally considered suitable for normal, oily and combination skin types because the ingredient is used at very low levels and is rinsed away or left on without altering the skin’s oil balance. People with very sensitive or eczema-prone skin may be more likely to react since this preservative is a known skin sensitizer, so they should be cautious when trying a new formula that contains it.

The molecule is fully synthetic and contains no animal-derived material which makes it acceptable for vegans and vegetarians. Its production process does not rely on animal testing in most regions although regulatory requirements may vary by country.

No strong evidence links topical methyldibromo glutaronitrile to developmental or hormonal issues, so pregnant or breastfeeding individuals are not automatically restricted from using products that contain it. That said this is not medical advice and anyone who is pregnant or nursing should review their skincare routine with a qualified health professional to be sure every ingredient suits their personal situation.

The preservative does not absorb UV light or generate free radicals when exposed to sunlight, so it is not known to cause photosensitivity. It also has no recorded effect on skin pigmentation or interactions with common actives like retinol or vitamin C.

Potential Side Effects/Adverse Reactions

Side effects from topical methyldibromo glutaronitrile differ from person to person. The points below list potential reactions that have been documented, but most users experience none of them when the preservative is used correctly by the product manufacturer.

  • Allergic contact dermatitis characterized by redness, itching and small blisters
  • General skin irritation such as stinging or burning on application
  • Worsening of existing eczema or atopic dermatitis patches
  • Swelling or hives in severe allergic responses
  • Eye irritation if a product accidentally enters the eye area

If any of these reactions occur stop using the product immediately and seek advice from a healthcare professional or dermatologist.

Comedogenic Rating

Rating: 0. Methyldibromo glutaronitrile is not an oily or waxy material and is used at very tiny percentages only to control microbes, so it does not create a film that can block pores. Its chemistry is quite different from fatty acids and plant oils that typically trigger breakouts, which is why it sits at the bottom of the comedogenic scale.

Because of this low rating it is generally considered safe for people who are prone to acne or frequent blemishes.

Although it is non-comedogenic some users may still experience irritation or allergy, which is unrelated to pore clogging but worth keeping in mind when choosing products.

Summary

Methyldibromo glutaronitrile serves a single but important job in cosmetics: it preserves water-based formulas by stopping bacteria, yeast and mold from multiplying. It does this by disrupting the microbes’ protein processes, letting lotions, shampoos and wipes stay fresh and stable for their intended shelf life.

Once popular in the 1980s and 1990s its use has dropped in recent years because several markets now restrict or ban it in leave-on products due to rising reports of skin sensitization. It still appears in some rinse-off items and niche formulas where its broad-spectrum power is valued.

When used within current regulatory limits the ingredient is considered safe for most healthy skin, but its potential to cause allergic dermatitis means caution is wise. As with any new skincare item do a small patch test first to be sure your skin is comfortable with the formula.

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