Methylthiophenyl Morpholino Isobutanone: What Is It, Cosmetic Uses, Benefits & Side Effects

Curious about this ingredient? In this article we're explaining exactly what it is and why it's used within cosmetic formulations.
Updated on: July 1, 2025
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We verify all information on this page using publicly available nomenclature standards from The Personal Care Products Council (PCPC), the European Commission's CosIng database and documentation provided directly by ingredient manufacturers. Our analysis is based on technical data from these sources to ensure accuracy and reliability.

What Is Methylthiophenyl Morpholino Isobutanone?

Methylthiophenyl Morpholino Isobutanone is a lab-crafted molecule officially named 1-Propanone, 2-methyl-1-[4-(methylthio)phenyl]-2-(4-morpholinyl). In simpler terms, it is a small synthetic compound built around a morpholine ring and a methylthio-substituted phenyl group, joined to an isobutanone backbone. Chemists first explored it while looking for stable, skin-friendly ingredients that could help hold complex formulas together. As research on advanced emulsions and gels grew in the early 2000s, formulators noticed that this molecule excelled at keeping ingredients evenly dispersed. Today it is produced through a multi-step reaction that links the morpholine ring to the phenyl group before adding the isobutanone side chain. The resulting material is purified, dried then milled into a fine powder ready for cosmetic use. You will most often spot it in sheet masks, leave-on moisturizers, silky serums, light lotions and some anti-aging concentrates where long-term ingredient stability is important.

Methylthiophenyl Morpholino Isobutanone’s Cosmetic Benefits/Uses

This ingredient is prized for one standout role in skincare.

As a binding agent, Methylthiophenyl Morpholino Isobutanone helps hold the various pieces of a formula together so the product stays smooth and uniform from the first application to the last. By locking oily and watery parts into a consistent mix, it prevents separation, improves texture and extends shelf life, which means a more reliable feel and performance each time you use the product.

Who Can Use Methylthiophenyl Morpholino Isobutanone

Methylthiophenyl Morpholino Isobutanone is considered skin friendly for most people, including dry, normal, combination and oily skin types. Its main job is to keep a formula stable, so it does not add heavy oils or harsh actives that could upset the skin’s balance. Extremely sensitive or compromised skin may want to proceed with caution since any synthetic additive can be a trigger when the skin barrier is already weakened.

The ingredient is fully synthetic and contains no animal derived matter, making it suitable for vegans and vegetarians. Production typically takes place in closed reactors without animal testing when the brand follows cruelty free guidelines.

No data suggests that topical use poses a special risk during pregnancy or while breastfeeding. Still, because hormonal shifts can make skin more reactive, and out of an abundance of caution, pregnant or nursing users should ask their doctor before starting any new product that contains this compound. This is general information, not medical advice.

Methylthiophenyl Morpholino Isobutanone does not cause photosensitivity. You can use it morning or night without increasing your chances of sunburn, though daily sunscreen is always wise for overall skin health.

Potential Side Effects/Adverse Reactions

Side effects and reactions to the topical application of Methylthiophenyl Morpholino Isobutanone can vary from person to person. The points below list potential issues only. When the ingredient is properly dosed in a well-made product most users will not notice any problems.

  • Mild skin irritation such as itching or slight redness
  • Transient stinging or burning on broken or very sensitive skin
  • Rare allergic contact dermatitis resulting in rash or swelling
  • Eye irritation if the product migrates too close to the lash line
  • Feeling heavy or pore clogging in very oily skin when used in rich formulas

If you notice any of the above while using a product that contains this ingredient stop application and seek advice from a qualified healthcare professional.

Comedogenic Rating

Rating: 1/5

Methylthiophenyl Morpholino Isobutanone is a lightweight synthetic binder that does not leave an oily film or create an occlusive layer on the skin. Because it mainly helps ingredients stay evenly mixed rather than coating the surface, it has little tendency to block pores. The trace amount typically used in formulas further keeps clogging risk low.

Suitable for acne-prone or breakout-prone skin in most cases.

Formulas heavy in butters or waxes may still feel rich, so consider the full ingredient list if you are extremely congestion sensitive.

Summary

Methylthiophenyl Morpholino Isobutanone acts primarily as a binding agent, holding oily and watery components together so a cream, lotion or serum stays smooth stable and effective from start to finish. By anchoring the mix it prevents separation improves texture and supports a longer shelf life.

It is not a headline star like hyaluronic acid or niacinamide, but chemists appreciate it for reliable behind-the-scenes work. You will spot it in a growing number of modern formulations, especially sheet masks and lightweight moisturizers that aim for a silky feel.

Current safety data shows a low risk of irritation for most users when used in standard concentrations. As with any new cosmetic ingredient, do a quick patch test with the finished product to make sure your skin agrees with it.

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