What Is Myristoyl Tetrapeptide-6?
Myristoyl Tetrapeptide-6 is a lab-made molecule created by linking myristic acid, a fatty acid found in nut and seed oils, with a short chain of four amino acids known as tetrapeptide-6. By combining a fatty acid with a peptide the compound gains the ability to slip into the skin’s surface more easily while still delivering the targeted benefits associated with peptides.
The use of small peptides in skincare started gaining attention in the 1990s as researchers looked for gentler ways to encourage firmer, smoother skin. Myristoyl Tetrapeptide-6 followed soon after, developed by cosmetic chemists who wanted to improve the skin-friendly nature of tetrapeptide-6 by attaching the naturally occurring fatty acid. The finished ingredient first appeared in premium anti-aging serums and eye creams before spreading into a wider range of products.
Manufacturing involves two key steps. First the tetrapeptide is produced through controlled fermentation or solid-phase synthesis. Separately myristic acid is sourced from plant oils such as coconut or nutmeg. The two components are then reacted together under precise temperature and pH conditions to form the final conjugated peptide, which is purified into a white to off-white powder ready for cosmetic use.
Today you will most often find Myristoyl Tetrapeptide-6 in leave-on formulas aimed at improving skin texture and resilience. Common product types include anti-aging serums, eye creams, firming lotions, overnight masks and lightweight moisturizers designed for daily use. Because it is stable and works well at low concentrations it can also appear in specialty spot treatments and booster ampoules.
Myristoyl Tetrapeptide-6’s Cosmetic Benefits/Uses
In skincare formulas Myristoyl Tetrapeptide-6 serves one primary role.
As a skin-conditioning ingredient it supports a smoother, more supple complexion. The peptide segment is thought to signal the skin to refresh its own support network of collagen and elastin while the myristic acid portion helps the molecule meld with the skin’s natural lipids. Regular use can translate to a softer feel, reduced appearance of fine lines and an overall healthier-looking surface which is why formulators add it to both preventive and corrective products.
Who Can Use Myristoyl Tetrapeptide-6
This peptide–fatty acid combo is generally well tolerated by all major skin types including dry, normal, combination and oily skin thanks to its lightweight nature and low use levels. Even sensitive skin can often handle it because the molecule is non abrasive and free of common irritants. Those with highly reactive or compromised skin should still evaluate the full product formula since other ingredients, not the peptide itself, may pose issues.
Myristoyl Tetrapeptide-6 is considered suitable for vegans and vegetarians because both the myristic acid and the tetrapeptide portion are typically sourced from plant materials or produced synthetically without animal derivatives.
Current research has not flagged special risks for pregnant or breastfeeding women when the ingredient is applied topically in cosmetic concentrations. That said this is not medical advice and anyone who is pregnant or nursing should run any skincare routine past a qualified healthcare professional to be on the safe side.
The ingredient does not increase photosensitivity so it can be used day or night, though daily sunscreen is still recommended for overall skin health.
Potential Side Effects/Adverse Reactions
Side effects and reactions to topical Myristoyl Tetrapeptide-6 can vary from person to person. The points below outline potential outcomes but they are not expected to be the typical experience when the ingredient is used at proper cosmetic levels.
Mild redness or warmth
Temporary itching or tingling at the application site
Rare allergic contact dermatitis marked by persistent rash or swelling
Interaction with other active ingredients that may heighten skin sensitivity if the overall formula is too strong
If any undesirable reaction occurs stop using the product and consult a healthcare professional for guidance.
Comedogenic Rating
Rating: 1 out of 5
Although myristic acid on its own can be pore clogging, in this molecule it is bonded to a tetrapeptide and used at very low concentrations. The peptide portion raises the overall water affinity while the fatty tail mainly helps penetration rather than sitting on the surface, so the likelihood of blocked pores is minimal. Because of this the ingredient is generally suitable for acne-prone or breakout-prone skin.
No published reports link Myristoyl Tetrapeptide-6 to increased sebum production or comedone formation. Its placement in lightweight serums and eye creams further lowers any risk since these formulas are typically oil-sparse.
Summary
Myristoyl Tetrapeptide-6 is a skin-conditioning active that aims to smooth, firm and soften by pairing a collagen-prompting tetrapeptide with a penetration-boosting fatty acid. The hybrid structure lets it slip through the outer skin layer so it can nudge cells to refresh collagen and elastin while also supporting the lipid barrier for a supple feel.
While not a household name like retinol or vitamin C, the ingredient has carved out a steady niche in mid to high-end anti-aging serums and eye treatments due to its gentle profile and compatibility with most skin types.
Current data show it is low risk with only rare reports of irritation when used in standard cosmetic levels. Still, everyone’s skin is unique so it is wise to patch test any new product that contains Myristoyl Tetrapeptide-6 before full application.