What Is Myristoyl Tripeptide-4?
Myristoyl Tripeptide-4 is a small, lab designed molecule made by linking myristic acid, a fatty acid found in coconut and nutmeg oils, to a chain of three amino acids known as tripeptide-4. Joining these parts gives the peptide a fatty “tail” that helps it mix well with skin’s natural oils and slip easily into the upper layers of the skin.
The idea of attaching fatty acids to peptides grew popular in the early 2000s when formulators looked for ways to improve how well peptides stay on the skin. Myristoyl Tripeptide-4 came out of that research and soon appeared in upscale skin care aimed at firming and smoothing.
The ingredient is produced through controlled laboratory synthesis. First, chemists build the tripeptide from individual amino acids using solid-phase peptide synthesis. They then couple the finished peptide with myristic acid under mild conditions, purify the reaction product, and check its quality so it meets cosmetic grade standards.
You will most often see Myristoyl Tripeptide-4 in leave-on products that promise anti-aging or firming benefits such as serums, eye creams, night creams and sheet masks. It can also show up in lightweight moisturizers and targeted treatments meant to improve skin texture.
Myristoyl Tripeptide-4’s Cosmetic Benefits/Uses
This ingredient has one main job in skin care
Skin conditioning: Myristoyl Tripeptide-4 helps skin feel softer, smoother and more supple. By improving the look and feel of the skin surface it supports a healthier appearance, which makes formulas with this peptide appealing in products that aim to reduce the visible signs of aging.
Who Can Use Myristoyl Tripeptide-4
Myristoyl Tripeptide-4 is generally considered suitable for all skin types, including dry, normal, combination and oily. Its lightweight nature means it will not leave a heavy or greasy finish, making it a comfortable addition for those with oilier skin, while its conditioning action can help relieve the tight feel often experienced by dry or mature skin. People with very sensitive or highly reactive skin should monitor how their skin feels when first introducing the peptide, as any new ingredient can pose a small chance of irritation for this group.
The ingredient is synthesized in a laboratory and is not derived from animals, so products that contain Myristoyl Tripeptide-4 are typically acceptable for both vegans and vegetarians. As always, it is best to check the overall product formula for any additional non-vegan components such as beeswax or certain types of collagen.
Current research has not flagged Myristoyl Tripeptide-4 as a concern for pregnant or breastfeeding women when used topically in standard cosmetic concentrations. That said, this is not medical advice and anyone who is pregnant or nursing should seek a doctor’s guidance before adding new skincare products to their routine to stay on the safe side.
The molecule does not make skin more sensitive to sunlight so it is not known to cause photosensitivity. Regular daytime sun protection is still recommended because UV exposure remains the leading cause of premature skin aging and damage.
Potential Side Effects/Adverse Reactions
Side effects and reactions to the topical use of Myristoyl Tripeptide-4 can vary from person to person. The points below list potential, but unlikely, reactions. When the ingredient is correctly formulated and used as intended most people will not experience any problems.
- Mild redness or warmth immediately after application
- Temporary stinging or tingling, especially on broken or freshly exfoliated skin
- Localized irritation in very sensitive individuals
- Allergic contact dermatitis presenting as itching, rash or swelling
- Eye irritation if the product accidentally gets into the eyes
If you notice any of these effects while using Myristoyl Tripeptide-4 or a product containing it, discontinue use and consult a healthcare professional for advice.
Comedogenic Rating
Rating: 1 out of 5. Myristoyl Tripeptide-4 contains a fatty myristic tail that could, in theory, add some occlusive feel, but it is used at very small percentages and is chemically bound to a water-loving peptide. This keeps it from behaving like free fatty acids that are known to clog pores. Formulas that rely on this peptide alone are unlikely to trigger blackheads or pimples, so it is generally considered safe for acne-prone skin.
Keep in mind that the overall product matters more than the single ingredient. If the serum or cream pairs the peptide with heavy oils or thick butters, the finished product could still feel greasy or occlusive.
Summary
Myristoyl Tripeptide-4 is a lab built peptide linked to myristic acid that conditions skin, helping it feel softer, smoother and more resilient. The fatty tail improves skin penetration while the peptide portion supports a healthier skin surface, so even low levels can give a subtle firming boost.
Although it is not as famous as retinol or vitamin C, the ingredient shows up in an increasing number of mid to high-end serums and eye creams because brands want fresh peptide options that are gentle yet effective.
Current data points to a very good safety profile with low risk of irritation or pore clogging when used as directed. As with any new skincare addition it is smart to patch test first to make sure your skin is happy with the formula.