What Is N-Caffeoyl Serotonin?
N-Caffeoyl Serotonin is a plant derived compound that blends two familiar molecules: caffeic acid, found in coffee beans and many fruits, and serotonin, a natural signal chemical found in the body. Chemists link these two parts together to form a new molecule with the formula C19H18N2O4. The ingredient first caught attention in the early 2000s when researchers noticed its strong antioxidant power, a trait prized in skin care. To make it, manufacturers start with natural caffeic acid, react it with serotonin under controlled lab conditions then purify the result to cosmetic grade. The finished powder dissolves well in creams and serums. Today you will mainly see N-Caffeoyl Serotonin in facial moisturizers, anti aging lotions, after sun products, sheet masks and specialty treatments that aim to shield skin from environmental stress.
N-Caffeoyl Serotonin’s Cosmetic Benefits/Uses
This ingredient is classed as a skin protecting agent. By neutralizing free radicals it helps guard skin cells from damage triggered by UV light and pollution. Added regularly to a formula it supports a healthier looking complexion with fewer signs of early aging.
Who Can Use N-Caffeoyl Serotonin
N-Caffeoyl Serotonin is gentle enough for most skin types. Dry, normal and combination skin usually welcome the added antioxidant support while oily and acne-prone skin can use it because the molecule itself is lightweight and non-greasy. Sensitive skin often tolerates it well although anyone with a known allergy to coffee plants should be cautious.
The compound is made by reacting plant derived caffeic acid with lab made serotonin so it contains no animal ingredients and is suitable for vegans and vegetarians.
Current research has not shown any specific risks for pregnant or breastfeeding women when N-Caffeoyl Serotonin is used in topical products. This information is not medical advice and anyone who is pregnant or nursing should check with a healthcare professional before adding new skincare to their routine just to be safe.
The ingredient does not make skin more sensitive to sunlight so it is not considered photosensitising. Standard daytime sunscreen use is still recommended for overall skin health.
Potential Side Effects/Adverse Reactions
Reactions to N-Caffeoyl Serotonin can differ from person to person. The points below list potential side effects although they are uncommon when the ingredient is used at the low levels found in finished cosmetics.
- Mild redness or warmth on application
- Temporary stinging or tingling
- Localised itching
- Contact dermatitis in individuals allergic to caffeic acid or related plant compounds
- Increased sensitivity if layered with strong exfoliating acids or retinoids
If any irritation or discomfort occurs stop using the product and seek guidance from a qualified healthcare provider.
Comedogenic Rating
Rating: 0 (non-comedogenic)
N-Caffeoyl Serotonin is a small water-compatible molecule that does not leave an oily film on skin, is used at very low percentages and has no known tendency to block pores. Because it does not add extra lipids or heavy waxes the chance of clogging follicles is minimal.
Suitable for acne-prone or breakout-prone skin.
Formulas that pair it with rich butters or comedogenic oils could still cause congestion, so the overall product base matters more than this single antioxidant.
Summary
N-Caffeoyl Serotonin is mainly valued as a skin protecting antioxidant. It neutralises free radicals generated by UV rays and pollution, helping preserve collagen and maintain a smooth even complexion. The ingredient is still a niche choice compared with staples like vitamin C or niacinamide, yet formulators include it when they want a gentle plant-inspired shield without stability problems.
Current data shows it is well tolerated by most skin types with a very low risk of irritation when used at cosmetic levels. As with any new product a short patch test is wise to check personal sensitivity before full face use.