What Is N-Nicotinoyl Tyramine?
N-Nicotinoyl Tyramine is an organic compound created by linking nicotinic acid, better known as vitamin B3, with tyramine, a natural derivative of the amino acid tyrosine. The result is an amide that combines the skin-friendly reputation of niacin derivatives with the soothing profile of amino acid components. First studied by chemists exploring new versions of vitamin B3 for cosmetic use, it gained attention once researchers noticed its ability to leave skin feeling smoother and more supple. Commercially, it is produced through a straightforward condensation reaction that joins purified nicotinic acid to tyramine under controlled temperature and pH, followed by filtration and drying to yield a stable, off-white powder.
Brands most often blend N-Nicotinoyl Tyramine into leave-on products where lasting skin contact matters. You will find it in lightweight serums aimed at boosting skin tone, daily moisturizers that promise a soft finish, richer night creams marketed for mature skin, sheet masks that focus on revitalization and specialty ampoules or essences designed to prep the skin before makeup.
N-Nicotinoyl Tyramine’s Cosmetic Benefits/Uses
In modern formulations N-Nicotinoyl Tyramine serves one main purpose that enhances how a product feels and performs on the skin.
As a skin-conditioning agent it helps maintain a smooth soft surface by supporting the outer layer of the skin, reducing rough texture and improving overall comfort. When included at suitable levels it can give creams a velvety after-feel, help serums glide more easily and leave masks with a gratifying, skin-hugging finish.
Who Can Use N-Nicotinoyl Tyramine
N-Nicotinoyl Tyramine is generally well tolerated by all major skin types including dry, normal, combination and oily. Its silky after-feel makes it especially pleasant for those with rough or dehydrated skin while the lightweight nature of most formulas containing it means it will not weigh down oilier complexions. There is no known reason for people with sensitive skin to avoid it, though any individual intolerance to niacin derivatives or amines would warrant caution.
The compound is synthesized from vitamin B3 and tyramine, both sourced without animal by-products, so it is considered suitable for vegans and vegetarians. Manufacturers can list it as a plant-based ingredient, provided the rest of the formula follows suit.
Current literature shows no specific risk to women who are pregnant or breastfeeding when the ingredient is applied topically at the low percentages used in cosmetics. Still this is not medical advice and anyone expecting or nursing should check with a healthcare professional before introducing new skincare products.
N-Nicotinoyl Tyramine does not cause photosensitivity, so it will not make skin more prone to sunburn. Standard daytime sun protection is still recommended for overall skin health. People on prescription treatments that already contain niacin derivatives should ensure the combined exposure remains within their doctor’s guidance.
Potential Side Effects/Adverse Reactions
Side effects from topical N-Nicotinoyl Tyramine vary from person to person. The points below outline potential reactions, though most users will not experience them when the ingredient is included at appropriate levels in a well-formulated product.
- Transient warmth or mild flushing in very sensitive skin
- Minor redness or irritation if the formula is applied to compromised skin
- Itching or tingling linked to individual allergy to niacin derivatives or amines
- Rare contact dermatitis presenting as persistent redness or patchy rash
- Possible interaction with prescription topical products containing high amounts of niacin or strong actives that already stimulate blood flow
If any of these reactions occur discontinue use and seek advice from a medical professional.
Comedogenic Rating
Rating: 1 out of 5. N-Nicotinoyl Tyramine is a small, water friendly molecule derived from vitamin B3 and an amino acid so it does not leave an oily film that could clog pores. It lacks long chain fatty acids or heavy waxes that usually raise the risk of breakouts. Because of that it is generally suitable for people who are prone to acne and congestion. Keep in mind that the finished product’s full recipe, how often you apply it and any other pore-clogging ingredients in the same routine will also influence whether pimples appear.
Summary
N-Nicotinoyl Tyramine is mainly used as a skin conditioning agent that helps skin feel softer and smoother while adding a pleasant slip to the formula. It achieves this by supporting the surface layers of the skin and improving texture without feeling greasy. Although it is not the hottest name in skincare and you will not spot it on every shelf, brands that favor gentle vitamin B3 relatives appreciate its mild performance.
Current research and real-world use show it to be low in irritation and very safe when used at the small amounts found in leave-on products. As with any new cosmetic, it is smart to do a quick patch test first to make sure your skin agrees with it.