What Is Nicotiana Benthamiana Hexapeptide-40 Sh-Polypeptide-2?
Nicotiana Benthamiana Hexapeptide-40 Sh-Polypeptide-2 is a lab designed fusion peptide that combines a short chain of six amino acids, known as Hexapeptide-40, with a larger single chain version of human thioredoxin. Scientists insert the synthetic human gene into leaves of the Nicotiana benthamiana plant, either for a short burst of production or as a stable part of the plant’s DNA. The plant then acts like a miniature factory, assembling a 110-amino-acid protein that may include helpful structural features such as disulfide bonds or light sugar attachments. After harvesting the leaves, the peptide is purified, filtered and dried into a fine powder ready to blend into cosmetic bases.
The technology behind it rose out of efforts to make human-identical proteins in fast growing plants for gentle topical use. As peptide research expanded in the skin care world during the early 2000s, brands began exploring plant-made versions to lower cost and avoid animal sources. Today, formulators add Nicotiana Benthamiana Hexapeptide-40 Sh-Polypeptide-2 to leave-on hair serums, strengthening masks, anti-aging creams, lightweight moisturizers and targeted treatment ampoules where a concentrated dose of conditioning peptides is desired.
Nicotiana Benthamiana Hexapeptide-40 Sh-Polypeptide-2’s Cosmetic Benefits/Uses
This multitasking peptide supports both skin and hair health when applied topically.
- Hair conditioning: Forms a thin, flexible film along the hair shaft that smooths cuticles, boosts softness and helps reduce breakage during brushing
- Skin conditioning: Binds water to the surface of the skin, improves suppleness and can lend a subtle tightening feel that makes the complexion appear fresher
Who Can Use Nicotiana Benthamiana Hexapeptide-40 Sh-Polypeptide-2
This peptide is considered gentle enough for all major skin types, including dry, oily, combination and mature. Sensitive complexions generally tolerate it well thanks to its low fragrance and dye profile, though anyone with a known allergy to tobacco plant proteins should proceed cautiously. Hair care formulas containing the peptide suit everything from fine strands to textured curls because the film-forming action is weightless and rinses clean.
The ingredient is produced entirely in a plant system without any animal by-products, so it is suitable for both vegetarians and vegans. No animal testing is required for its manufacture, aligning it with most cruelty-free standards.
Current data show no specific risks for pregnant or breastfeeding women when the peptide is used topically at cosmetic concentrations, but this is not medical advice. Anyone who is expecting or nursing should ask their health professional before adding new products to their routine, just to be safe.
Nicotiana Benthamiana Hexapeptide-40 Sh-Polypeptide-2 does not increase photosensitivity, so it can be used morning or night. Regular sunscreen use is still encouraged as part of a complete skincare regimen.
Potential Side Effects/Adverse Reactions
Side effects and reactions to the topical application of Nicotiana Benthamiana Hexapeptide-40 Sh-Polypeptide-2 can vary from person to person. The points below list potential issues only and are not expected to occur for the average user when the ingredient has been properly formulated.
- Mild redness or stinging in highly reactive skin
- Itchiness linked to rare plant protein allergy
- Contact dermatitis if used in products with inadequate preservative systems
- Eye irritation if a hair or skin formula accidentally enters the eyes
If any uncomfortable reaction develops, stop use immediately and consult a healthcare professional for guidance.
Comedogenic Rating
Rating: 0 / 5. Nicotiana Benthamiana Hexapeptide-40 Sh-Polypeptide-2 is a water-soluble peptide with no oily or waxy components, so it does not clog pores or encourage buildup inside follicles. It stays on the surface to hydrate and smooth then rinses or wears away cleanly. For this reason it is generally suitable for acne-prone or breakout-prone skin. Because its behavior depends on the rest of the formula, extremely heavy creams that also contain rich oils could still pose a pore-clogging risk, but the peptide itself remains non-comedogenic.
Summary
Nicotiana Benthamiana Hexapeptide-40 Sh-Polypeptide-2 conditions hair by laying down a light flexible film that reduces friction and breakage while leaving strands softer. On skin it binds water, supports a smoother texture and provides a momentary tightening feel that freshens the look of the complexion. Despite the sophisticated plant-bioengineering behind it, the ingredient is still relatively niche and is found mainly in premium serums masks and specialty boosters rather than mass-market products.
Current data show the peptide to be low risk when used as directed, with few reports of irritation or allergy. As with any new cosmetic addition it is wise to run a small patch test first to rule out personal sensitivities before applying a full dose.