What Is Nicotiana Benthamiana Sh-Polypedtide-7?
Nicotiana Benthamiana Sh-Polypedtide-7 is a lab-designed version of human somatotropin, produced in the leaves of the Nicotiana benthamiana plant. Scientists insert a copy of the human growth hormone gene into the plant’s cells, then let the plant act as a mini factory that assembles the peptide from the standard twenty amino acids. After the leaves grow, the peptide is extracted, purified, filtered and dried into a stable powder that can be blended into skincare formulas. The result is a single-chain protein of up to 217 amino acids that may contain natural stabilising features like disulfide bonds or light glycosylation.
The technology behind this ingredient grew out of pharmaceutical research in the early 2000s that explored plant-based expression systems as a safer, greener alternative to bacterial or animal sources. As costs dropped and purification methods improved, cosmetic chemists saw an opportunity to bring bioidentical peptides into everyday skincare. Today Nicotiana Benthamiana Sh-Polypedtide-7 shows up in concentrated anti-aging serums, firming moisturisers, sheet masks, targeted eye creams and post-treatment soothing gels where brands want to offer a gentle boost to skin resilience and texture.
Nicotiana Benthamiana Sh-Polypedtide-7’s Cosmetic Benefits/Uses
This bioengineered peptide is valued for one key function in topical products.
As a skin conditioning agent it helps the skin feel softer and look smoother, supports a healthy moisture balance, encourages a more even texture and can give a plumper, firmer appearance over time.
Who Can Use Nicotiana Benthamiana Sh-Polypedtide-7
This peptide is generally well tolerated by all major skin types including dry, oily, combination and sensitive skin because it is lightweight and non greasy. People prone to irritation may even find it calming since it has no added fragrance or harsh solvents. At this time there are no known reasons for acne prone or rosacea prone users to avoid it.
The ingredient is produced in a tobacco plant rather than an animal source so it is suitable for vegans and vegetarians. No animal derived materials are used at any point in its production or purification.
Current safety data on topical use during pregnancy or breastfeeding is limited. No direct risks have been identified but hormone related compounds can sometimes act differently in these life stages. This is not medical advice and pregnant or nursing individuals should check with a doctor before adding any new skincare product that contains it, just to be safe.
Nicotiana Benthamiana Sh-Polypedtide-7 does not increase photosensitivity and can be used morning or night. It layers well with most common skincare actives including vitamin C, niacinamide and retinoids, though applying it to broken skin or open wounds should be avoided until the area has healed.
Potential Side Effects/Adverse Reactions
Side effects and reactions to topical Nicotiana Benthamiana Sh-Polypedtide-7 can vary from person to person. The points below note potential issues, yet most users will not experience any negative effects when the ingredient is formulated and used correctly.
- Mild redness or warmth shortly after application
- Temporary tingling or itchiness in highly sensitive skin
- Rare allergic response such as localized swelling or hives
- Contact dermatitis if combined with an incompatible preservative system
If any of these reactions occur stop using the product and seek medical advice if symptoms persist or worsen.
Comedogenic Rating
Rating: 0 / 5
Nicotiana Benthamiana Sh-Polypedtide-7 is a large water-soluble peptide that sits on the skin surface and rinses away easily. It has no oils, waxes or fatty acids that could block pores so it earns the lowest possible score.
That makes it a comfortable choice for people who are prone to acne or frequent breakouts.
The only caveat is that finished products can still clog pores if they contain heavy emollients or rich plant butters. Check the full ingredient list if congestion is a concern.
Summary
Nicotiana Benthamiana Sh-Polypedtide-7 is a lab grown copy of human growth hormone used in skincare as a skin-conditioning agent. By sitting on the surface it helps skin feel soft and smooth, supports moisture balance and can give a firmer look over time.
It is still a niche ingredient found mostly in higher-end serums and creams, though its plant-based production keeps costs lower than animal-derived peptides and interest is slowly rising among indie brands.
Current data points to a strong safety record with very low risk of irritation or acne. As with any new product, do a quick patch test first to make sure your skin agrees with the full formula.