Nonyl Nonoxynol-100: What Is It, Cosmetic Uses, Benefits & Side Effects

Curious about this ingredient? In this article we're explaining exactly what it is and why it's used within cosmetic formulations.
Updated on: June 30, 2025
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We verify all information on this page using publicly available nomenclature standards from The Personal Care Products Council (PCPC), the European Commission's CosIng database and documentation provided directly by ingredient manufacturers. Our analysis is based on technical data from these sources to ensure accuracy and reliability.

What Is Nonyl Nonoxynol-100?

Nonyl Nonoxynol-100 is a man-made ingredient that belongs to the nonionic surfactant family. Chemically it is created by attaching about 100 units of ethylene oxide to nonylphenol, giving a long chain that is water loving at one end and oil loving at the other. This split personality lets it grab onto dirt and oils while still mixing well with water.

The material was first introduced in the cleaning industry in the mid-1900s, then moved into personal care when formulators noticed it could cleanse skin and hair without the heavy suds or strong alkalinity of traditional soaps. Today it is produced in two main steps: phenol is first alkylated with a nonyl group to make nonylphenol, then this base is reacted with ethylene oxide in controlled conditions until the desired average of 100 repeating units is reached. The finished paste or liquid is filtered and standardized before shipment to cosmetic manufacturers.

You will most often spot Nonyl Nonoxynol-100 in facial cleansers, micellar waters, makeup removers, body washes, shampoos, exfoliating masks and occasional in-shower treatments aimed at oily or acne-prone skin. Its high ethoxylate number makes it especially useful in formulas that need to remove heavy makeup or sunscreen without leaving a greasy film.

Nonyl Nonoxynol-100’s Cosmetic Benefits/Uses

In beauty products Nonyl Nonoxynol-100 serves mainly one purpose that brings several practical benefits to a formula.

Cleansing: As a nonionic surfactant it lowers the surface tension of water so oils, sweat and makeup can be lifted away and rinsed off. Because it has no charge it tends to be milder than many anionic detergents, which helps reduce the risk of dryness or tightness after washing. It also works well alongside other surfactants, boosting their foam and improving the overall rinse-off feel.

Who Can Use Nonyl Nonoxynol-100

Products containing Nonyl Nonoxynol-100 are generally suitable for normal, combination and oily skin types since the ingredient excels at lifting excess sebum and heavy makeup without leaving residue. Dry or very sensitive skin may find frequent use a bit stripping because the surfactant can remove some of the skin’s natural lipids. If you fall into those categories look for formulas where it appears lower on the ingredient list or is paired with replenishing oils and humectants.

Because Nonyl Nonoxynol-100 is synthesized entirely from petrochemical feedstocks it involves no animal-derived materials, making it acceptable for vegans and vegetarians. Always double-check the full product label though because other ingredients in the same formula might not share that status.

Current cosmetic safety assessments have not flagged Nonyl Nonoxynol-100 as a specific concern for women who are pregnant or breastfeeding. Still this is not medical advice and anyone expecting or nursing should run all skincare choices past their doctor just to be safe.

The ingredient does not make skin more sensitive to sunlight and it does not interfere with sunscreen performance. It is also odorless so it typically will not clash with fragrance in a routine.

Potential Side Effects/Adverse Reactions

Responses to topical Nonyl Nonoxynol-100 vary person to person. The points below list potential reactions yet most users will not run into these issues when the ingredient is formulated and used correctly.

  • Skin dryness or tightness, especially with overuse on already dry skin
  • Mild stinging or redness on very sensitive or compromised skin
  • Contact dermatitis in individuals allergic to nonylphenol derivatives
  • Eye irritation if the product is accidentally rubbed into the eyes
  • Rare acne flare-ups in those who are highly reactive to surfactants

If you notice any of these effects stop using the product and consult a healthcare professional or dermatologist for guidance.

Comedogenic Rating

Rating: 1/5 – Nonyl Nonoxynol-100 is a large, water-soluble surfactant that does not readily stay on skin and is typically rinsed off, so it has a very low tendency to clog pores. Its molecular size and high ethoxylation keep it from forming films that would trap sebum or dead cells. Because of this low score it is generally fine for those prone to acne or breakouts. In leave-on formulas the chance of congestion could rise slightly, yet such use is uncommon. No reputable studies link the ingredient to increased comedone formation.

Summary

Nonyl Nonoxynol-100 is mainly a cleansing agent that loosens makeup, sunscreen, excess oil and everyday grime so they can be rinsed away. It works by lowering surface tension, allowing water to mix with oils while its nonionic nature keeps it gentler than many traditional detergents. You will see it most often in robust face washes, micellar waters and makeup removers, though it is not as mainstream as classic surfactants like sodium laureth sulfate. Safety reviews deem it low risk aside from possible dryness or mild irritation on very sensitive skin. As with any new skincare product it is smart to do a quick patch test first to be sure your skin agrees with the formula.

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