Octapeptide-31: What Is It, Cosmetic Uses, Benefits & Side Effects

Curious about this ingredient? In this article we're explaining exactly what it is and why it's used within cosmetic formulations.
Updated on: June 30, 2025
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We verify all information on this page using publicly available nomenclature standards from The Personal Care Products Council (PCPC), the European Commission's CosIng database and documentation provided directly by ingredient manufacturers. Our analysis is based on technical data from these sources to ensure accuracy and reliability.

What Is Octapeptide-31?

Octapeptide-31 is a lab-created chain of eight amino acids arranged in a set order of alanine, arginine, glycine, serine and tyrosine. Because it is synthetic there is no animal or plant source; instead manufacturers build the peptide step by step using solid-phase peptide synthesis, a method that attaches one amino acid at a time to a resin until the full sequence is complete. Peptides first drew cosmetic interest in the early 1990s when researchers saw that small fragments of proteins could send helpful signals to skin. Octapeptide-31 joined the roster as demand grew for targeted anti-aging actives that were lighter than whole proteins yet more specific than botanical extracts. After synthesis the peptide is purified, blended into a carrier such as glycerin or water, then added to finished formulas. You will most often spot it in leave-on products like serums, eye creams, high-performance moisturizers and sheet masks aimed at improving the look of fatigued or uneven skin.

Octapeptide-31’s Cosmetic Benefits/Uses

Octapeptide-31 appears on ingredient lists with the function name “skin conditioning,” which sums up its main benefit in topical products. By helping skin stay smooth, supple and well hydrated the peptide supports a healthier looking complexion. Formulators value it because it can enhance softness without adding heavy oils, making it suitable for lightweight age-defying blends as well as richer creams for dry skin.

Who Can Use Octapeptide-31

Octapeptide-31 is considered suitable for most skin types including normal, dry, combination and oily skin because it offers conditioning benefits without adding heavy oils or pore-clogging ingredients. Those with very sensitive or compromised skin should introduce it gradually since any new active can occasionally provoke irritation. The molecule is synthetic and contains no animal derivatives so it aligns with vegan and vegetarian lifestyles. Pregnant or breastfeeding individuals are not known to face specific risks from topical Octapeptide-31, yet this does not replace medical advice and anyone expecting or nursing should review their full skincare routine with a healthcare provider. The peptide does not cause photosensitivity so there is no special need to avoid sunlight beyond standard daily SPF use. It also has no known conflicts with common cosmetic categories such as retinoids, AHAs or niacinamide, making it an easy addition to multi-step routines.

Potential Side Effects/Adverse Reactions

Responses to topical Octapeptide-31 vary by individual. The points below outline potential adverse effects, though these outcomes are uncommon when the ingredient is properly formulated and used as directed.

  • Mild redness or irritation, especially on very reactive skin
  • Transient stinging or warming sensation after application
  • Rare cases of allergic contact dermatitis marked by itching or rash
  • Excess dryness or flaking if layered with multiple strong exfoliants

If any negative reaction occurs stop using the product and seek guidance from a dermatologist or healthcare professional.

Comedogenic Rating

Rating: 0 / 5

Octapeptide-31 is a water soluble peptide with no inherent oils, waxes or fatty acids so it does not create the type of film that can trap sebum and dead cells inside pores. Because it stays lightweight and rinses clean during normal cleansing, the risk of blocked follicles is extremely low. For these reasons it is considered non-comedogenic and is generally a safe choice for skin that breaks out easily. One caveat is that finished formulas can include richer emollients; if you are acne prone check the full ingredient list rather than judging by the peptide alone.

Summary

Octapeptide-31 is a lab crafted chain of eight amino acids used primarily for skin conditioning. By supporting the skin barrier and attracting water it helps keep the surface smooth, supple and balanced, which can visually soften fine lines and dryness without adding heaviness. Although not as well known as big-name peptides like Matrixyl it is quietly gaining traction in targeted serums, eye treatments and high-end moisturizers where formulators want a light yet effective conditioning agent.

The ingredient has an excellent overall safety record with low irritation and zero comedogenic concerns when properly formulated. Still, everyone’s skin chemistry is unique, so it is smart to patch test any new product that features Octapeptide-31 before applying it widely.

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