Oleamidopropyl Dimethylamine Glycolate: What Is It, Cosmetic Uses, Benefits & Side Effects

Curious about this ingredient? In this article we're explaining exactly what it is and why it's used within cosmetic formulations.
Updated on: June 30, 2025
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We verify all information on this page using publicly available nomenclature standards from The Personal Care Products Council (PCPC), the European Commission's CosIng database and documentation provided directly by ingredient manufacturers. Our analysis is based on technical data from these sources to ensure accuracy and reliability.

What Is Oleamidopropyl Dimethylamine Glycolate?

Oleamidopropyl Dimethylamine Glycolate is a specialty ingredient created by reacting oleic acid, a fatty acid commonly sourced from plant oils like olive or sunflower, with dimethylaminopropylamine. The resulting compound is then combined in a one-to-one ratio with glycolic acid, giving the material both a fatty tail and a water-friendly head. This dual nature makes it valuable for hair care because it can cling to damaged strands while still rinsing clean.

The ingredient emerged in the late 1990s when formulators were looking for greener replacements for traditional quaternary ammonium conditioners. By using a naturally derived fatty acid and avoiding permanent quats, manufacturers could offer gentler conditioning without the buildup associated with older ingredients.

Production begins with the amidation of oleic acid and dimethylaminopropylamine under controlled heat. The amide is then neutralized with glycolic acid to create a salt that is easier to incorporate into water-based formulas. Quality control checks pH, purity and color before the ingredient is shipped as a liquid concentrate.

You’ll most often find Oleamidopropyl Dimethylamine Glycolate in rinse-off hair products such as shampoos, conditioners and co-wash creams. It can also appear in leave-in sprays, anti-frizz serums and some hair masks where lightweight conditioning and static control are desired.

Oleamidopropyl Dimethylamine Glycolate’s Cosmetic Benefits/Uses

This ingredient plays more than one role in hair care formulas

  • Antistatic – Reduces the surface charge that makes hair strands repel each other which cuts down on flyaways and helps styles stay smoother for longer
  • Hair Conditioning – Deposits a thin lubricating layer on the cuticle so hair feels softer is easier to detangle and gains a subtle shine without heaviness

Who Can Use Oleamidopropyl Dimethylamine Glycolate

Because it is typically incorporated into rinse off hair products Oleamidopropyl Dimethylamine Glycolate is considered suitable for all scalp and hair types including oily dry and color treated strands. Its mild cationic nature gives conditioning benefits without leaving a heavy film so even fine hair generally tolerates it well. People with extremely sensitive or allergy prone skin should note that the ingredient contains an amine group and a glycolic acid salt which in rare cases might lead to tingling or redness along the hairline.

The fatty acid portion is normally sourced from plant oils which means the material is usually vegan and vegetarian friendly. Brands that certify their supply chain can confirm whether any animal derived feedstocks were used in production.

No specific warnings exist for pregnant or breastfeeding women when this ingredient is used in standard cosmetic concentrations. It is classed as low hazard and is largely rinsed away during use. This is not medical advice and anyone who is expecting or nursing should review all personal care products with a qualified healthcare professional just to be safe.

Oleamidopropyl Dimethylamine Glycolate does not increase photosensitivity so there is no added need for sun protection beyond normal daily habits.

Potential Side Effects/Adverse Reactions

Responses to topical Oleamidopropyl Dimethylamine Glycolate vary from person to person. The points below outline potential issues yet most users will not experience them when the ingredient is formulated and used correctly.

  • Scalp or skin irritation – A small number of people may notice itching redness or a burning sensation especially if they already have a compromised scalp barrier
  • Allergic contact dermatitis – Rare hypersensitivity to the amide or amine portion could lead to localized rash or swelling
  • Eye irritation – Direct contact with eyes can cause stinging and watering until thoroughly rinsed
  • Product buildup – Overuse in leave in products may weigh hair down and leave it looking limp or greasy

If any discomfort or adverse effect occurs stop using the product and seek advice from a medical professional or dermatologist.

Comedogenic Rating

Rating: 1 / 5

Oleamidopropyl Dimethylamine Glycolate earns a low score because the molecule is partly water soluble and is almost always rinsed out during normal use. Its fatty portion is too large to slip into most facial pores and the salt form prevents it from lingering on skin for long. As a result it rarely blocks follicles or triggers breakouts.

This makes the ingredient generally suitable for people who are prone to acne or congestion, especially when it appears in wash off hair products where contact with facial skin is brief.

If a leave in formula also contains heavy oils or waxes those companions, not this conditioner, are more likely to contribute to clogged pores.

Summary

Oleamidopropyl Dimethylamine Glycolate is valued as an antistatic agent and lightweight hair conditioner. Its fatty tail grips damaged cuticles while the water friendly head carries a mild positive charge that smooths the hair surface, reduces static and adds slip for easier detangling.

The ingredient is still a bit of a niche pick compared with long-standing quats but its plant based origin and clean rinsing feel are helping it gain traction in modern shampoos, co-washes and leave ins aimed at consumers who want softness without buildup.

Overall safety is considered high since the compound is low irritation, mostly rinsed away and used at modest levels. As with any new personal care product it is smart to do a quick patch test before full use just to be cautious.

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