What Is Oligopeptide-107 Rh-Polypeptide-1?
Oligopeptide-107 Rh-Polypeptide-1 is a lab-designed fusion peptide made up of 67 amino acids, the same building blocks found naturally in skin. Scientists start by digitally designing a gene that combines sequences from two smaller peptides, Oligopeptide-107 and Rh-Polypeptide-1. This custom gene is inserted into a harmless strain of E. coli, which acts like a miniature factory. During fermentation the bacteria read the gene, churn out the peptide chain, then the mixture is purified, filtered and dried into a fine powder ready for cosmetic labs.
Peptides became popular in skincare in the early 2000s for their ability to signal skin cells to look and act younger. As research advanced, brands sought longer, more targeted chains, leading to the creation of fusion peptides like Oligopeptide-107 Rh-Polypeptide-1. Today you will most often spot it in anti-aging serums, rich moisturizers, sheet masks, eye creams and post-treatment soothing gels where it is valued for its skin-conditioning talent.
Oligopeptide-107 Rh-Polypeptide-1’s Cosmetic Benefits/Uses
In cosmetics this ingredient is used mainly for one key purpose: skin conditioning. By supporting the skin’s natural proteins it helps improve softness, boost hydration, enhance firmness and promote an overall healthier look and feel, making formulas more effective and pleasant to use.
Who Can Use Oligopeptide-107 Rh-Polypeptide-1
This lab made peptide is gentle enough for dry, oily and combination skin and is usually well tolerated by sensitive types because it does not strip, clog or sting. People with a known allergy to peptides or fermentation by-products should be cautious, otherwise there are no specific skin types that must avoid it.
The peptide is produced through bacterial fermentation with no animal derived material so it is considered suitable for vegans and vegetarians.
No studies have linked topical Oligopeptide-107 Rh-Polypeptide-1 to problems during pregnancy or while breastfeeding. Research is limited though, so this is not medical advice and anyone who is pregnant or nursing should show their doctor any product they plan to use just to be safe.
The ingredient does not increase photosensitivity, making it fine for daytime use under sunscreen. It also layers well with most actives such as vitamin C, niacinamide and retinoids without known conflicts.
Potential Side Effects/Adverse Reactions
Responses to topical Oligopeptide-107 Rh-Polypeptide-1 differ from person to person. The points below outline potential but unlikely reactions when the ingredient is used correctly in a well-formulated product.
- Mild redness or warmth shortly after application
- Temporary itching or tingling in very sensitive skin
- Localized rash or hives in cases of peptide allergy
- Contact dermatitis if combined with an irritant preservative or fragrance
If any of these effects appear stop using the product and seek advice from a healthcare professional.
Comedogenic Rating
Rating: 0/5 (non-comedogenic)
Oligopeptide-107 Rh-Polypeptide-1 is a water-soluble peptide that contains no oils, waxes or heavy silicones that might clog pores. Its large molecular size keeps it on the surface instead of sinking into follicles so it does not encourage blackheads or breakouts.
Suitable for acne-prone or congestion-prone skin.
The peptide is normally used at very low levels and is often blended into lightweight formulas so it rarely alters the overall pore-clogging potential of a product.
Summary
Oligopeptide-107 Rh-Polypeptide-1 is a 67-amino-acid fusion peptide that conditions skin by supporting its own proteins, improving moisture retention and promoting a smoother firmer feel. It works by resting on the surface and sending signals that nudge cells toward healthier behavior, making creams, serums and masks feel more effective.
It is not as famous as household-name peptides yet it is steadily gaining traction in niche anti-age offerings where brands look for fresh lab-designed actives.
Research suggests the ingredient is low risk for irritation, non-comedogenic and vegan friendly so most people can use it with confidence. Still, it is wise to patch test any new product that contains it before full-face application to rule out personal sensitivities.