What Is Oligopeptide-107 Sh-Polypeptide-7?
Oligopeptide-107 Sh-Polypeptide-7 is a lab designed peptide made by combining the genetic blueprints for two smaller peptides into one 208 amino-acid chain. Scientists insert this custom gene into harmless strains of E. coli, then ferment the bacteria so they churn out large amounts of the peptide. After purification the result is a highly consistent ingredient free of animal-derived material.
Peptide technology has been part of skincare since the early 2000s, but newer fusion peptides like Oligopeptide-107 Sh-Polypeptide-7 offer greater stability and targeted performance. Because its amino-acid sequence mirrors fragments naturally found in the skin it is easily recognized by skin cells.
You will most often spot this peptide in leave-on products that aim to improve skin feel and appearance such as lightweight serums, anti-aging creams, moisturizing lotions, sheet masks and eye treatments. It may also appear in high-performance boosters that are added to an existing routine for a concentrated effect.
Oligopeptide-107 Sh-Polypeptide-7’s Cosmetic Benefits/Uses
In formulas this ingredient serves one primary purpose
Skin conditioning: Oligopeptide-107 Sh-Polypeptide-7 helps skin feel smoother and more supple by supporting the surface proteins that keep the moisture barrier intact. Regular use can leave the complexion looking plumper and more refreshed while enhancing the overall sensory feel of a product.
Who Can Use Oligopeptide-107 Sh-Polypeptide-7
This peptide is considered friendly for all major skin types including dry, oily, combination and sensitive skin because it is lightweight and non-occlusive. People prone to sensitivity may appreciate that it is fragrance-free and produced without common irritants, although extremely reactive skin should still monitor for any new redness or stinging.
It is vegan and vegetarian suitable. The production process relies on fermented E. coli in a lab setting so there are no animal-derived inputs or by-products involved.
Current safety data does not flag any specific issues for pregnant or breastfeeding individuals. Still, this is not medical advice and anyone expecting or nursing should confirm suitability with a healthcare professional before adding new skincare to their regimen.
Oligopeptide-107 Sh-Polypeptide-7 does not make skin more prone to sunburn and can be used both morning and night. Standard daily sunscreen use is still recommended for overall skin health.
The ingredient layers well with most actives, including retinoids, vitamin C and exfoliating acids, without neutralizing their effects.
Potential Side Effects/Adverse Reactions
Reactions to topical Oligopeptide-107 Sh-Polypeptide-7 differ from one person to the next. The following points list potential side effects, though they are uncommon when the peptide has been formulated correctly and applied as directed.
- Mild redness or warmth at the application site
- Temporary itching or tingling
- Rare allergic contact dermatitis in those already sensitized to peptides or fermentation residuals
- Breakouts in highly acne-prone skin if the final product also contains comedogenic ingredients
If any discomfort or adverse change occurs discontinue use and seek guidance from a qualified healthcare provider.
Comedogenic Rating
Rating: 0 / 5. Oligopeptide-107 Sh-Polypeptide-7 is water soluble with no oily or waxy parts that could clog pores. It sits on skin briefly, delivers its conditioning signal, then absorbs or rinses away without leaving a residue that can trap dead cells or sebum.
This makes it suitable for people who are prone to acne or breakouts. As always the rest of the formula matters, so check the full ingredient list if you are very clog-prone.
Summary
Oligopeptide-107 Sh-Polypeptide-7 is a lab made fusion peptide that conditions skin by supporting barrier proteins and helping the surface hold moisture. The result can be skin that feels smoother looks plumper and shows fewer early lines.
It is still a niche ingredient found mostly in high-end serums and targeted boosters, yet its stability and vegan origin are winning it more spots in new launches each year.
Current research and real-world use point to a high safety profile with low risk of irritation or clogged pores. Even so skin can be unpredictable, so do a quick patch test when trying any new product that contains this peptide just to be safe.