What Is Oligopeptide-108?
Oligopeptide-108 is a lab made chain of 19 amino acids that include alanine, asparagine, cysteine, glycine, histidine, leucine, lysine, tryptophan and valine. Chemists build it through a method called solid phase peptide synthesis, which lets them link each amino acid in a set order for consistent quality. It first attracted attention in the early 2000s when brands searched for gentle yet effective ingredients that could support the skin’s own repair signals. Since the peptide can be produced without any animal material it fits neatly into the modern push for vegan friendly formulas.
After production the finished powder is blended into water based solutions, then added to products that aim to smooth, hydrate or soothe the skin. You will usually spot Oligopeptide-108 in lightweight serums, anti aging creams, eye gels, sheet masks and post treatment soothing lotions, where it works alongside familiar hydrators like glycerin or hyaluronic acid.
Oligopeptide-108’s Cosmetic Benefits/Uses
Oligopeptide-108 is prized for one main job in skincare.
Skin conditioning: the peptide helps keep the surface of the skin feeling soft and supple. By reinforcing the skin’s natural moisture barrier it can reduce dryness and make the complexion look smoother and more even. When used regularly it supports a healthy skin feel that enhances the overall performance of moisturizers and serums that carry it.
Who Can Use Oligopeptide-108
Oligopeptide-108 is generally well suited to all skin types, including normal, dry, oily and combination skin, because its main role is to condition and support the moisture barrier without leaving a heavy or greasy feel. Sensitive skin usually tolerates the peptide too, as it has a low potential for irritation, though very reactive skin should still be mindful of the full formula the peptide is delivered in.
The ingredient is synthetically produced and contains no animal components, making it appropriate for both vegans and vegetarians.
Current research has not flagged Oligopeptide-108 as unsafe for pregnant or breastfeeding women when used topically. That said, this information is not medical advice and anyone who is pregnant or nursing should check with their healthcare provider before adding new skincare products to their routine.
Oligopeptide-108 does not cause photosensitivity, so it will not make skin unusually prone to sunburn. Standard daytime sun protection is still recommended to guard against everyday UV damage.
Potential Side Effects/Adverse Reactions
Responses to topical Oligopeptide-108 can differ from person to person. The following is a list of potential side effects that could occur in rare cases. Most users should not expect to experience these issues when the ingredient is formulated and used correctly.
- Mild redness or warmth in the area of application
- Itching or tingling for individuals with very sensitive skin
- Temporary stinging if applied to compromised or freshly exfoliated skin
- Contact dermatitis in the event of an individual allergy to the peptide or other formula components
If any of these reactions are noticed the product should be rinsed off, use discontinued and professional medical guidance sought as needed.
Comedogenic Rating
Rating: 0/5
Oligopeptide-108 is a small water soluble peptide that does not trap oil or debris inside pores, so it carries no pore-clogging risk on its own. Its primary job is to bind moisture and leave a light, non-greasy finish, which is why it receives a 0 out of 5.
Because of this, the ingredient is considered friendly for acne-prone or breakout-prone skin.
Keep in mind that the overall feel of a product also depends on the other ingredients it contains. If a formula includes heavy oils or waxes those components, not the peptide, could raise the likelihood of congestion.
Summary
Oligopeptide-108 is a lab crafted chain of 19 amino acids that conditions skin, supports its natural moisture barrier and leaves the surface feeling smoother and more comfortable. It performs these tasks by sitting on the top layers of skin, attracting water molecules and helping them stay put.
While still less famous than long-standing actives like retinol or vitamin C, the peptide is showing up more often in lightweight serums, eye gels and recovery masks thanks to its gentle profile and vegan origin.
Current research rates it as very safe for topical use with minimal chance of irritation or pore blockage. That said every skin is different, so give any new product containing Oligopeptide-108 a quick patch test before moving it into regular rotation.