What Is Oligopeptide-116?
Oligopeptide-116 is a lab-created chain of 12 amino acids made up of asparagine, aspartic acid, glutamine, glycine and lysine. Because it is synthetic, it can be produced with high purity and stability, giving formulators a reliable ingredient that behaves the same way from batch to batch.
The rise of bioactive peptides in skin care began in the late 1990s when researchers saw that short amino acid chains could signal the skin to behave in a more youthful way. Oligopeptide-116 is part of this wave, designed to offer conditioning benefits without the drawbacks sometimes seen with larger proteins or animal-derived extracts.
Manufacturing happens through solid-phase peptide synthesis, a step-by-step method where each amino acid is added in sequence. After the chain is complete, it is purified and carefully dried, resulting in a fine powder that dissolves easily in water-based cosmetic formulas.
You will most often spot Oligopeptide-116 in serums, anti-aging creams, sheet masks, eye treatments, lightweight moisturizers and targeted firming lotions where a silky skin feel and supportive care are desired.
Oligopeptide-116’s Cosmetic Benefits/Uses
Oligopeptide-116 is valued for its skin conditioning ability, helping products leave the skin feeling soft, smooth and well cared for. By supporting the skin’s surface, it can enhance the overall sensorial experience of a formula while contributing to a healthier-looking complexion.
Who Can Use Oligopeptide-116
Oligopeptide-116 is generally considered suitable for all skin types including dry, normal, combination, oily and sensitive skin because it is lightweight, water soluble and non occlusive. Those with very reactive or allergy-prone skin may still want to be cautious, as they would with any new ingredient, but the peptide itself is regarded as low risk for irritation.
Because Oligopeptide-116 is entirely synthetic and contains no animal-derived components, it aligns with vegan and vegetarian lifestyles.
No research suggests that the peptide poses a specific risk to women who are pregnant or breastfeeding. That said, this is not medical advice and anyone who is pregnant or nursing should discuss any skincare product they plan to use with a qualified healthcare professional.
Oligopeptide-116 does not increase photosensitivity, so it will not make the skin more prone to sunburn. Standard daytime sun protection is still recommended when using any modern skincare routine.
Potential Side Effects/Adverse Reactions
Side effects and reactions to the topical application of Oligopeptide-116 can vary from person to person. The points below outline potential issues, though most users will not experience them when the ingredient is formulated and used correctly.
- Mild redness or warmth shortly after application
- Transient itching or stinging, especially on compromised skin
- Localized rash or hives indicating an allergic response
- Contact dermatitis in individuals sensitive to peptides or accompanying formula components
- Eye irritation if the product is applied too close to the lash line
If any of these reactions occur discontinue use and seek advice from a healthcare professional or dermatologist.
Comedogenic Rating
Rating: 0
Oligopeptide-116 is a small, water-soluble peptide that does not leave an oily or waxy residue on the skin. It lacks the heavy lipids and fatty acids that typically clog pores, so it earns a non-comedogenic score of 0. This makes it suitable for those prone to acne or breakouts. Because it dissolves fully in water and is used at low concentrations, it does not build up in follicles or create an environment where blemish-causing bacteria thrive.
Formulators often pair the peptide with lightweight bases such as gels or serums, further reducing any pore-blocking risk. If the finished product includes richer emollients, the overall formula may influence pore activity more than the peptide itself.
Summary
Oligopeptide-116 acts primarily as a skin-conditioning agent, helping products deliver a softer, smoother feel while supporting a healthy-looking complexion. Its 12-amino-acid chain can signal the skin’s surface to maintain a balanced moisture environment, contributing to a refreshed appearance without heaviness.
The ingredient is still a niche choice compared with big-name peptides like Matrixyl or copper tripeptides, but its stability and vegan profile are gaining attention among indie and clean beauty brands looking for reliable lab-made actives.
Current data show Oligopeptide-116 to be low risk for irritation, sensitization or pore clogging, making it broadly safe for daily use. As with any new skincare ingredient, it is wise to patch test when introducing a product containing this peptide to ensure personal compatibility.