What Is Oligopeptide-123 Rh-Polypeptide-1?
Oligopeptide-123 Rh-Polypeptide-1 is a lab made fusion peptide created through fermentation in the common bacterium E. coli. Scientists join two separate gene sequences, one for Oligopeptide-123 and one for rh-Polypeptide-1, then let the bacteria read this combined genetic code and churn out a single chain of up to 288 amino acids. After purification the result is a clear, water-soluble ingredient that can slip easily into skin care formulas.
The use of designer peptides in cosmetics began gaining popularity in the early 2000s when brands searched for gentler yet effective anti-aging actives. As peptide research expanded formulators learned to link or “fuse” different peptide sequences to get multiple benefits in one molecule. Oligopeptide-123 Rh-Polypeptide-1 is a product of that trend and is now found in modern moisturizing creams, anti-aging serums, sheet masks, eye treatments and post-procedure soothing gels.
Oligopeptide-123 Rh-Polypeptide-1’s Cosmetic Benefits/Uses
This ingredient is valued for one clear job in skin care.
As a skin conditioning agent it helps the surface of the skin feel softer, smoother and more supple. The peptide’s amino acid sequence is designed to mimic parts of the skin’s own building blocks so it can support the natural barrier, draw in light moisture and leave a conditioned finish. In anti-aging lines that means a plumper look and improved texture while in soothing formulas it can reduce that tight, dry feeling that often follows cleansing or professional treatments.
Who Can Use Oligopeptide-123 Rh-Polypeptide-1
This peptide suits almost every skin type including dry, normal, combination, oily and sensitive because it is lightweight and non-occlusive. People dealing with very severe acne should focus more on the full formula of a product rather than the peptide itself as the ingredient is not known to clog pores or spark breakouts on its own.
Oligopeptide-123 Rh-Polypeptide-1 is produced through bacterial fermentation without any animal derived raw materials so it is considered suitable for both vegans and vegetarians.
No specific warnings exist for pregnant or breastfeeding women regarding topical use of this peptide but human safety studies in these groups are limited. This is not medical advice and anyone who is expecting or nursing should discuss new skincare products with a qualified healthcare provider just to be safe.
The ingredient is not known to cause photosensitivity so it can be used morning or night. Routine sunscreen is still recommended for overall skin health.
Potential Side Effects/Adverse Reactions
Reactions to topical Oligopeptide-123 Rh-Polypeptide-1 vary from person to person. The issues listed below are possible yet uncommon when the ingredient is included at typical cosmetic levels in a well-formulated product.
- Temporary redness: Mild flushing may appear if the skin is highly reactive or if the product also contains other stimulating actives
- Itching or stinging: Can occur on very sensitive skin especially if applied to compromised or freshly exfoliated areas
- Contact dermatitis: Rare allergic response marked by rash swelling or intense itching
- Breakouts: More likely linked to heavy oils or silicones in a formula rather than the peptide itself but acne prone users could notice clogged pores if the overall product is not suitable
- Eye irritation: Possible if the product accidentally migrates into the eyes particularly in high-water formulations like serums or essences
If any persistent or severe reaction develops stop using the product and seek advice from a medical professional or dermatologist.
Comedogenic Rating
Rating: 0 out of 5
Oligopeptide-123 Rh-Polypeptide-1 is water soluble and used at very low concentrations so it does not form a film that blocks pores. It lacks heavy oils or waxes that are typically linked with breakouts which is why it receives the lowest possible comedogenic score.
Suitable for acne prone or breakout prone skin.
No known interactions with common acne treatments such as benzoyl peroxide or salicylic acid have been reported so it can usually be layered without issue.
Summary
Oligopeptide-123 Rh-Polypeptide-1 is a lab made fusion peptide that acts mainly as a skin conditioning agent. By mimicking small pieces of the skin’s own proteins it helps reinforce the natural barrier draws in light hydration and leaves the surface feeling smooth supple and slightly plumper.
The ingredient is still considered niche compared with household names like hyaluronic acid but its inclusion is growing in modern moisturizers serums and post-procedure care thanks to solid lab data and a gentle profile.
Overall safety is high with low risk of irritation or pore clogging for most users. As with any new skincare product it is wise to perform a quick patch test first to be sure your skin responds well.