What Is Oligopeptide-62?
Oligopeptide-62 is a lab-created chain of 12 amino acids made from arginine, asparagine, cysteine, glycine, leucine, lysine, phenylalanine and tyrosine. Because it is synthetic, each batch can be produced with the same purity and performance, something that is harder to guarantee with naturally derived proteins. Peptides like this started drawing attention in the early 2000s when researchers noticed that small fragments of proteins could send signals to skin cells that help them look and feel healthier. Oligopeptide-62 is built through solid-phase peptide synthesis, a step-by-step method that links one protected amino acid to the next, followed by purification and drying into a fine powder ready for formulation. You will most often see it in anti-aging serums, firming creams, targeted eye treatments, sheet masks and high-performance moisturizers where brands want to promote a smoother, more resilient complexion.
Oligopeptide-62’s Cosmetic Benefits/Uses
In skin care formulas Oligopeptide-62 serves one key purpose: skin conditioning. By improving the feel and appearance of the skin surface it helps products deliver a softer, more supple finish while supporting a fresher overall look.
Who Can Use Oligopeptide-62
Because Oligopeptide-62 is a gentle skin conditioning peptide it is generally suitable for all skin types, including dry, oily, combination, mature and even sensitive complexions. It has no occlusive oils or exfoliating acids that might clog pores or strip the skin, so acne-prone users usually tolerate it well. Those with extremely reactive or compromised skin should still monitor how their skin feels, as any new ingredient has the potential to trigger discomfort in rare cases.
The peptide is produced entirely in the lab without animal-derived materials, so it meets vegan and vegetarian standards.
Current safety data suggest that topical use during pregnancy or breastfeeding poses a very low risk because peptides are too large to penetrate deeply into the bloodstream. That said this is not medical advice and anyone who is pregnant or nursing should ask a healthcare professional before adding a new skincare product to their routine.
Oligopeptide-62 does not make skin more sensitive to sunlight, so it can be used morning or night without increasing the chance of sunburn. As with any routine daily sunscreen is still recommended.
The peptide pairs well with most common skincare actives, including niacinamide, hyaluronic acid and non-exfoliating forms of vitamin C, so layering is typically straightforward.
Potential Side Effects/Adverse Reactions
Individual responses to topical Oligopeptide-62 can vary. The issues listed below are only potential reactions and, when the ingredient is properly formulated, most users will not experience them.
- Mild redness or flushing
- Transient itching or tingling
- Localized dryness if used in a high-strength formula without adequate moisturizers
- Allergic contact dermatitis in people sensitive to one of the amino acid residues or other formula components
- Stinging around the eye area when applied too close to the lash line
If any discomfort or visible reaction develops stop using the product and seek guidance from a dermatologist or qualified healthcare professional.
Comedogenic Rating
Rating: 0 (non-comedogenic). Oligopeptide-62 is water-soluble, oil-free and used in very low concentrations, so it does not sit in pores or create the kind of film that can trap sebum and debris. Its molecular size and structure make it unlikely to worsen congestion, which means it is generally suitable for skin that is prone to acne or breakouts. Because it functions strictly as a skin-conditioning peptide and is usually paired with lightweight bases, there are no fatty acids or waxes in the ingredient itself that would push the rating higher.
Formulas that combine Oligopeptide-62 with heavy butters or oils can still clog pores, so look at the full ingredient list if you are highly reactive to richer textures.
Summary
Oligopeptide-62 is a lab-crafted 12-amino-acid peptide used to condition skin, helping the surface feel smoother and look more resilient by supporting the skin’s own renewal signals. It fits seamlessly into modern formulas because it dissolves easily in water, remains stable and works at low doses.
While not as famous as collagen-boosting peptides like Matrixyl, it is quietly gaining traction in targeted serums, eye creams and sheet masks aimed at firmness and overall skin vitality. Most users tolerate it well due to its non-comedogenic profile and lack of known irritants.
Current safety data shows a very low risk of adverse effects, making it appropriate for nearly all skin types. As with any new skincare ingredient, do a quick patch test before full use to ensure personal compatibility.