What Is Oligopeptide-67?
Oligopeptide-67 is a lab-made chain of 12 amino acids that include aspartic acid, glutamine, leucine, lysine, methionine, phenylalanine, threonine and valine. Chemists designed this short peptide to mimic signals that naturally occur in skin, which makes it useful for boosting how the skin looks and feels. The ingredient appeared in cosmetic research in the early 2000s when peptide technology began to gain attention for its ability to target specific skin concerns without the heaviness of traditional oils or waxes.
Creating Oligopeptide-67 starts with solid-phase peptide synthesis. Each amino acid is added to a growing chain in a precise order, then the finished peptide is purified and dried into a fine powder. Because it is synthetic the process can be tightly controlled, which helps keep the ingredient stable and consistent from batch to batch.
You will most often find Oligopeptide-67 in lightweight serums, anti-aging creams, sheet masks, eye gels and specialty boosters aimed at smoothing texture or reducing the look of fine lines. It is also included in some post-procedure products that focus on calming and conditioning the skin.
Oligopeptide-67’s Cosmetic Benefits/Uses
Oligopeptide-67 is valued in skincare for one main role, and that role brings several practical perks to everyday formulas.
Skin Conditioning: By supporting the skin’s natural proteins, this peptide helps soften rough patches and improves overall suppleness. A conditioned skin surface can better hold moisture, appear smoother and feel more comfortable, which is why brands often pair Oligopeptide-67 with hydrators like hyaluronic acid or glycerin.
Who Can Use Oligopeptide-67
Because it is lightweight and free of oils, fragrances and dyes, Oligopeptide-67 is generally suitable for all skin types including dry, normal, combination, oily and sensitive skin. Its gentle nature makes it a sensible choice for people who cannot tolerate heavier emollients or strong actives, though anyone with a known peptide allergy should avoid it.
The peptide is made entirely in a lab from individual amino acids so it contains no animal derived material. This makes products featuring Oligopeptide-67 compatible with vegan and vegetarian lifestyles.
No evidence currently links topical Oligopeptide-67 with risks during pregnancy or while breastfeeding. Still, this is not medical advice and anyone who is pregnant or nursing should show the full ingredient list of any cosmetic product to a qualified healthcare provider before use to be extra safe.
Oligopeptide-67 does not trigger photosensitivity, meaning it will not make skin more prone to sunburn. Daily sunscreen is still recommended as part of a well-rounded routine.
Potential Side Effects/Adverse Reactions
Responses to topical Oligopeptide-67 vary by individual. The following list covers potential side effects that could occur, but most users will not experience them when the ingredient is formulated and used correctly.
- Mild redness – temporary flushing can appear if skin is very reactive to new peptides
- Itching or stinging – a transient tingling may occur, especially on compromised or freshly exfoliated skin
- Contact dermatitis – rare allergic reactions may lead to localized swelling, rash or persistent irritation
- Breakouts – uncommon clogged pores can develop if the formula pairs the peptide with heavier occlusives that do not suit oily or acne-prone skin
If any of these reactions arise, discontinue use and seek advice from a qualified healthcare professional
Comedogenic Rating
Rating: 0 / 5 – Oligopeptide-67 is a small, water-soluble molecule that is used at very low levels and contains no oily or waxy components, so it does not obstruct pores on its own. This makes it well suited for people who are prone to acne or breakouts. As with any ingredient, the finished product’s overall texture and supporting ingredients determine its pore-clogging potential, so always consider the full formula rather than a single component.
Summary
Oligopeptide-67 is mainly a skin-conditioning peptide that helps skin feel softer, look smoother and hold moisture more comfortably by mimicking natural protein signals. Although it performs a helpful role, it is still a niche ingredient and has not reached the popularity of larger peptide families like palmitoyl peptides or copper peptides. Current research and consumer experience show it to be low risk for irritation or clogged pores, making it generally safe for daily use. As with any new skincare product, performing a small patch test before full application is a smart way to confirm personal compatibility.