What Is Oligopeptide-91 Rh-Oligopeptide-1?
Oligopeptide-91 rh-Oligopeptide-1 is a lab-made fusion peptide created by joining the genetic blueprints for two well-known skin peptides: rh-Oligopeptide-1, which is a version of epidermal growth factor, and Oligopeptide-91. Scientists build a single 74-amino-acid chain, insert its gene into harmless strains of E. coli, then let the bacteria ferment in large tanks so they can churn out the peptide. After fermentation the mixture is filtered and purified until only the desired peptide remains, giving formulators a consistent high-purity powder.
Peptides first appeared in anti-aging creams in the early 2000s. As research advanced, brands began blending or fusing peptides to target several skin concerns at once. Oligopeptide-91 rh-Oligopeptide-1 is part of this new generation, offering a compact way to deliver multiple amino-acid signals in one molecule.
You will mostly spot this ingredient in concentrated anti-aging serums, firming moisturizers, sheet masks, eye creams, post-procedure soothing gels and ampoules designed to support a smoother stronger skin barrier.
Oligopeptide-91 Rh-Oligopeptide-1’s Cosmetic Benefits/Uses
In skin care formulas this fusion peptide plays a couple of helpful roles:
- Skin conditioning – helps the surface of the skin feel softer and more supple, supports natural renewal signals, and can improve the look of fine lines for a fresher appearance
- Skin protecting – encourages a healthier barrier by supporting key proteins like collagen and elastin which helps defend against everyday environmental stress
Who Can Use Oligopeptide-91 Rh-Oligopeptide-1
This peptide suits almost every skin type including dry, oily, combination and mature skin because it is lightweight and non occlusive. Sensitive skin usually tolerates it well since the molecule is gentle and free of fragrances and common irritants. People with very reactive or allergy-prone skin may still wish to monitor how their skin feels because any new ingredient has a small chance of causing issues.
The peptide is produced by fermenting a lab-made gene in harmless E. coli then purifying the finished material, so no animal parts are involved. That makes it acceptable for vegans and vegetarians.
Current research has not flagged Oligopeptide-91 Rh-Oligopeptide-1 as unsafe for pregnant or breastfeeding women. Even so this is not medical advice and anyone who is expecting or nursing should review any skincare product with a qualified doctor to be extra sure.
The ingredient does not increase photosensitivity and can be used morning or night. As with most peptides it layers well with other actives like vitamin C or niacinamide without special precautions.
Potential Side Effects/Adverse Reactions
Reactions to topical Oligopeptide-91 Rh-Oligopeptide-1 vary from person to person. The following points list potential side effects, though they are uncommon when the ingredient is properly formulated and used as directed:
- Temporary redness or flushing
- Mild itching or tingling
- Localized irritation in very sensitive skin
- Allergic contact dermatitis in rare cases
- Breakouts if the overall formula is too rich for acne-prone skin
If any unwanted reaction occurs stop using the product and consult a healthcare professional.
Comedogenic Rating
Rating: 0 / 5
Oligopeptide-91 Rh-Oligopeptide-1 is a large water-soluble peptide that does not clog pores on its own so it earns the lowest possible comedogenic score. It lacks oily carriers or waxy residues that normally trap dead skin cells inside follicles. Because of this it is generally fine for those who are prone to acne or breakouts.
Any chance of pore blockage would come from the overall formula rather than from the peptide itself so always check the full ingredient list if congestion is a concern.
Summary
Oligopeptide-91 Rh-Oligopeptide-1 conditions skin and helps defend its barrier by delivering a lab-crafted signal sequence that nudges cells to keep collagen elastin and other structural proteins in good shape. This can smooth fine lines and leave skin feeling stronger and more supple.
The peptide shows up mostly in premium serums masks and post-procedure products so it is still more of a rising star than a mainstream staple. Formulators appreciate the reliable lab production and high purity while users like that it is lightweight fragrance free and free of animal origin.
Overall safety data look solid with irritation or allergy reports being rare. Even so skin is personal so do a small patch test whenever you bring home a new product that lists Oligopeptide-91 Rh-Oligopeptide-1.