Oligopeptide-93: What Is It, Cosmetic Uses, Benefits & Side Effects

Curious about this ingredient? In this article we're explaining exactly what it is and why it's used within cosmetic formulations.
Updated on: June 30, 2025
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We verify all information on this page using publicly available nomenclature standards from The Personal Care Products Council (PCPC), the European Commission's CosIng database and documentation provided directly by ingredient manufacturers. Our analysis is based on technical data from these sources to ensure accuracy and reliability.

What Is Oligopeptide-93?

Oligopeptide-93 is a lab made chain of 11 amino acids built from arginine and methionine. Because it is synthetic the makers can control its purity and performance, which helps keep results steady from batch to batch. Peptides like this first drew interest in skin care in the early 2000s when researchers saw that small protein fragments could signal the skin to look and feel healthier. Manufacturers create Oligopeptide-93 by joining its amino acids in a specific order through solid-phase peptide synthesis, then purifying the finished chain and drying it into a fine powder. Brands typically add this powder to water based solutions, serums, creams and sheet masks, especially those aimed at firming, smoothing or general anti aging care.

Oligopeptide-93’s Cosmetic Benefits/Uses

In formulas Oligopeptide-93 acts as a skin conditioning agent, meaning it helps the skin feel softer and look more even. By supporting the skin’s surface it can improve texture, boost a healthy glow and enhance the overall sensory feel of a product.

Who Can Use Oligopeptide-93

Because it is light and non greasy Oligopeptide-93 tends to suit all major skin types including dry, normal, combination and oily. Sensitive skin usually tolerates it well since it lacks strong acids or fragrances, though individuals with a history of peptide allergies should be cautious. The ingredient is synthetic and contains no animal derived components so it is appropriate for vegetarians and vegans.

No specific warnings exist for pregnant or breastfeeding women, yet hormones can make skin unpredictable during these times. This content is not medical advice and anyone who is expecting or nursing should have a doctor review their full routine before starting a new product, just to be safe.

Oligopeptide-93 does not make skin more reactive to sunlight and therefore does not add to photosensitivity risks. It can be used day or night and pairs well with sunscreen in a morning routine. There are no known ingredient clashes, so it can generally be layered with other common actives like niacinamide, hyaluronic acid or gentle antioxidants.

Potential Side Effects/Adverse Reactions

Side effects from topical Oligopeptide-93 differ from person to person. The points below outline potential reactions yet most users will not notice any issues when a formula is produced and used correctly.

  • Mild redness or warmth shortly after application
  • Transient itching or stinging on very sensitive skin
  • Localised rash or hives in rare cases of peptide allergy
  • Flare-up of existing dermatitis when applied to broken or compromised skin

If any of these reactions occur stop using the product and seek guidance from a healthcare professional.

Comedogenic Rating

Rating: 0 – Non comedogenic

Oligopeptide-93 is a small water soluble peptide that does not form an oily or waxy film, contains no pore-clogging lipids and is typically used at low levels. Because it rinses cleanly and allows the skin to breathe it is very unlikely to trigger blackheads or breakouts.

That means it is generally safe for acne prone skin.

Remember the finished product’s pore-clogging potential depends on the entire ingredient list, so always look at the full formula if congestion is a worry.

Summary

Oligopeptide-93 is an 11-amino-acid signal peptide that conditions skin by smoothing texture and supporting a healthier look. Its lightweight water friendly nature makes it easy to add to serums creams and masks, where it quietly boosts softness and glide.

While peptides as a group have become popular Oligopeptide-93 remains a specialty choice most often found in higher end or targeted treatments rather than mass market lines.

Overall it shows a solid safety record: non comedogenic, non photosensitising and well tolerated by all main skin types with only rare mild irritation reports. As with any new product a quick patch test is smart before fully committing, just to confirm your skin’s comfort.

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