What Is Palmitoyl Dipeptide-28 D-Serine Dipeptide-7 Palmitamide?
Palmitoyl Dipeptide-28 D-Serine Dipeptide-7 Palmitamide is a lab-made peptide created by linking three short chains of amino acids and then attaching palmitic acid, a fatty acid found in palm oil and many plant and animal fats. The palmitic acid helps the peptide blend into skin’s natural oils and reach the surface layers where it can do its work. Peptides started gaining attention in skin care in the early 2000s when researchers found that certain chains could signal skin cells to behave in a younger healthier way. This particular peptide was developed to take that idea further by combining multiple mini peptides with a fatty tail for better delivery.
Manufacturers build it through solid-phase peptide synthesis, which means they add one amino acid at a time on a resin bead, detach the finished chain, then couple it with palmitic acid. The result is a stable ingredient that dissolves well in creams and serums.
You will usually see Palmitoyl Dipeptide-28 D-Serine Dipeptide-7 Palmitamide in anti-aging serums, firming moisturizers, eye creams, sheet masks and leave-on treatments that target fine lines or a rough skin surface.
Palmitoyl Dipeptide-28 D-Serine Dipeptide-7 Palmitamide’s Cosmetic Benefits/Uses
This peptide is prized for one main job in skin care formulas.
Skin conditioning: it helps skin feel softer, smoother and better hydrated by supporting the natural proteins that keep the surface firm and elastic. Formulators use it to improve overall texture, boost moisture retention and give a more youthful look.
Who Can Use Palmitoyl Dipeptide-28 D-Serine Dipeptide-7 Palmitamide
This peptide is considered gentle and works well for most skin types, including dry, oily and combination. Its fatty acid tail helps it sit comfortably on the skin without leaving a heavy or greasy feel, which makes it suitable even for easily congested skin. People with very sensitive or reactive skin can generally use it too, though they may want to introduce it slowly to be sure their skin agrees with the full formula.
The ingredient is made entirely in a lab from non animal sources, so it is appropriate for vegans and vegetarians.
No data points to risks specific to pregnant or breastfeeding women, but research on newer peptides is limited. This information is not medical advice and anyone who is pregnant or nursing should check with a doctor before adding a new product to their routine.
Palmitoyl Dipeptide-28 D-Serine Dipeptide-7 Palmitamide does not increase photosensitivity, so you do not need special sun precautions beyond the usual daily sunscreen.
Potential Side Effects/Adverse Reactions
Responses to topical Palmitoyl Dipeptide-28 D-Serine Dipeptide-7 Palmitamide differ from person to person. The issues listed below are possible but unlikely for most users when the ingredient is properly formulated and used as directed.
- Mild redness or irritation
- Itchiness or a short-lived stinging sensation right after application
- Breakouts in those extremely prone to clogged pores
- Allergic contact dermatitis in rare cases
If any uncomfortable reaction appears stop using the product and seek guidance from a healthcare professional.
Comedogenic Rating
Rating: 1/5
Palmitoyl Dipeptide-28 D-Serine Dipeptide-7 Palmitamide contains a palmitic acid tail, which by itself can be pore clogging in high amounts, but this peptide is used at very low concentrations where the fatty portion is too small to create build-up. The molecule is also water-dispersible within an emulsion, further lowering the chance of it sitting in pores. It therefore earns a low score of 1.
Suitable for acne-prone skin, though overall formula and accompanying ingredients still matter.
Levels above 2 percent are uncommon; if a product lists it near the top of the ingredient list, pair it with lightweight textures to stay on the safe side.
Summary
Palmitoyl Dipeptide-28 D-Serine Dipeptide-7 Palmitamide is a lab-made peptide that conditions skin by nudging cells to support collagen and elastin while its palmitic acid tail improves penetration and leaves a soft finish. Thanks to these actions it helps smooth texture, improve firmness and enhance moisture retention.
It is a niche ingredient that appears mainly in mid- to high-end anti-aging formulas rather than everyday moisturizers, so you may not see it on every shelf yet.
Current data points to excellent safety with only rare irritation or clogging, but as with any new skincare ingredient perform a simple patch test before full use to make sure your skin is happy with the complete formula.