What Is Palmitoyl Sh-Oligopeptide-79?
Palmitoyl Sh-Oligopeptide-79 is a small chain of amino acids that has been joined to palmitic acid, a fatty acid naturally found in many plants and animals. The palmitic part makes the peptide more oil loving, helping it blend smoothly into creams and other leave-on products. The peptide itself is created in a lab, then reacted with palmitic acid chloride to form the final ingredient.
This type of peptide technology started gaining attention in the early 2000s when brands began looking for gentler ways to support skin and nail appearance. Today Palmitoyl Sh-Oligopeptide-79 is produced through controlled synthesis: scientists build the peptide step by step, purify it, then attach the palmitic acid. The result is a stable, easy-to-use powder or liquid that dissolves in the oil phase of a formula.
You will most often see this ingredient in nail serums, cuticle oils, hand creams, strengthening base coats and multi-benefit hand masks where its main goal is to condition and protect keratin surfaces.
Palmitoyl Sh-Oligopeptide-79’s Cosmetic Benefits/Uses
Formulators include Palmitoyl Sh-Oligopeptide-79 to give nail products an extra care boost.
Its primary role is nail conditioning, meaning it helps keep nails flexible, smooth and less prone to splitting. By coating the nail plate and supporting natural keratin, it leaves nails looking healthier with a subtle shine, improving overall manicure longevity.
Who Can Use Palmitoyl Sh-Oligopeptide-79
Palmitoyl Sh-Oligopeptide-79 is gentle enough for all skin types including dry, oily, combination and sensitive because it is non irritating and used at very low levels. People with highly reactive or allergy-prone skin should still read ingredient lists carefully in case the finished product contains other triggers.
The ingredient is made through laboratory synthesis and the palmitic acid portion is typically sourced from plants such as palm or coconut so it is generally suitable for vegans and vegetarians. Those who follow a strict lifestyle may want to confirm the brand’s sourcing policy to be sure no animal derivatives were used.
No specific warnings have been issued for pregnant or breastfeeding women. The molecule is large, stays on the surface and is not known to penetrate deeply or interfere with hormonal pathways. That said this text is not medical advice and anyone who is pregnant or nursing should run any cosmetic product past a healthcare professional just to be safe.
Palmitoyl Sh-Oligopeptide-79 does not make skin or nails more sensitive to sunlight so it is fine to use morning or night without increasing the risk of sunburn. It also plays well with other common actives such as niacinamide, vitamin C and retinol.
Potential Side Effects/Adverse Reactions
Side effects from topical Palmitoyl Sh-Oligopeptide-79 can vary from person to person. The points below list potential reactions yet they are uncommon when the ingredient is formulated and used correctly.
- Mild redness or warmth especially on very sensitive skin
if the user is allergic to the peptide or another ingredient in the product - Contact dermatitis presenting as a rash or flaking around the application area
- Follicular clogging and small breakouts if a rich formula is applied to facial skin prone to congestion
If any irritation or unusual reaction occurs discontinue use and seek advice from a medical professional.
Comedogenic Rating
Rating: 1/5
Palmitoyl Sh-Oligopeptide-79 is used at very low concentrations and remains mostly on the surface, so it has little chance of blocking pores. While the palmitic acid portion is lipid based, the peptide backbone keeps the overall molecule bulky and less likely to settle inside follicles, leading to a low comedogenic score.
Suitable for acne-prone or breakout-prone skin in most cases.
Formulas that pair this peptide with heavier butters or waxes could raise the overall pore-clogging potential, so the full ingredient list still matters.
Summary
Palmitoyl Sh-Oligopeptide-79 is a lab-crafted peptide linked to palmitic acid that conditions nails by forming a flexible, protective film over the keratin surface. This film helps reduce splitting, boosts smoothness and imparts a healthy shine.
The ingredient sits in a niche corner of the market, appearing mainly in targeted nail serums rather than mainstream skin care. Brands value it for its stability and user-friendly safety profile, but it has yet to reach superstar status.
Overall safety is high: it is non irritating for most users, non photosensitizing and vegan friendly when plant-sourced. As with any new cosmetic, patch testing a small area first is a smart habit to catch unexpected sensitivities.