Peg-12 Diisostearate: What Is It, Cosmetic Uses, Benefits & Side Effects

Curious about this ingredient? In this article we're explaining exactly what it is and why it's used within cosmetic formulations.
Updated on: July 1, 2025
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We verify all information on this page using publicly available nomenclature standards from The Personal Care Products Council (PCPC), the European Commission's CosIng database and documentation provided directly by ingredient manufacturers. Our analysis is based on technical data from these sources to ensure accuracy and reliability.

What Is Peg-12 Diisostearate?

Peg-12 Diisostearate is a synthetic ingredient created by joining isostearic acid, a fatty acid often derived from plant oils, with polyethylene glycol. The result is a waxy, partly water-loving molecule that can link oil and water in a stable mix. Chemists first explored this type of compound in the mid-20th century when the beauty industry needed smoother, lighter creams. Today manufacturers produce Peg-12 Diisostearate through a controlled reaction that binds about twelve units of ethylene oxide to diisostearic acid, then purifies the blend for skin care use. You will commonly spot it in lotions, moisturizers, makeup removers, cleansing balms, sunscreens, hair conditioners and color cosmetics where a silky, non-greasy feel is desired.

Peg-12 Diisostearate’s Cosmetic Benefits/Uses

This ingredient is valued for one main job in beauty formulas.

As an emulsifying agent Peg-12 Diisostearate helps oil and water join together so a product stays smooth and uniform from the first use to the last. A good emulsifier prevents creams from splitting, improves spreadability and allows lighter textures that absorb quickly without leaving a heavy film.

Who Can Use Peg-12 Diisostearate

Peg-12 Diisostearate suits most skin types including dry, normal, combination and oily because it gives slip without leaving a heavy residue. It is usually gentle enough for sensitive skin although anyone with a history of reactions to polyethylene glycol should proceed with extra caution. Acne-prone users tend to tolerate it well since it is not highly occlusive and rinses clean.

The ingredient itself is made from plant-derived fatty acids blended with synthetic polyethylene glycol so it is typically free of animal material. That means it can fit vegan and vegetarian lifestyles provided the brand confirms a plant source for the isostearic acid and does not test the finished product on animals.

Peg-12 Diisostearate has no known hormone-like activity and very little is expected to penetrate deep into the body, so formulators generally consider it acceptable during pregnancy or while breastfeeding. This is not medical advice and anyone who is pregnant or nursing should ask a doctor before adding new skincare products just to be safe.

The ingredient does not make skin more sensitive to sunlight and has no reported conflicts with common actives such as retinol or vitamin C. It can even improve the feel of products that contain those ingredients by keeping the emulsion stable.

Potential Side Effects/Adverse Reactions

Reactions to topically applied Peg-12 Diisostearate vary from person to person. The effects listed below are only possibilities and are unlikely for most users when the ingredient is used at the levels approved for cosmetics.

  • Mild redness or stinging in very sensitive skin
  • Contact dermatitis in people allergic to polyethylene glycol derivatives
  • Eye irritation if a product containing it is rubbed into the eyes
  • Clogged pores if combined with heavy oils in high-richness formulas

If any irritation, swelling or other unwanted reaction occurs stop using the product and consult a healthcare professional.

Comedogenic Rating

Rating: 1/5

Peg-12 Diisostearate contains a fatty acid backbone but its chain is heavily modified with water-loving polyethylene glycol units. This makes the molecule more soluble and less likely to sit in pores compared with straight plant oils or waxes. Published ingredient databases and formulator reports rarely flag it as a pore-clogging culprit, so it earns a low score of 1.

With that rating the ingredient is generally considered suitable for skin prone to acne or breakouts, especially when used in lightweight formulas.

Formulas that pair Peg-12 Diisostearate with high levels of rich butters or mineral oil could still feel heavy on very oily skin, so the overall recipe matters as much as the single ingredient.

Summary

Peg-12 Diisostearate is chiefly an emulsifier that keeps oil and water smoothly blended, improves spreadability and gives creams a light non-greasy slip. It does this by anchoring its fatty portion in oils while its polyethylene glycol side bonds with water, bridging the two phases so the product stays stable.

The ingredient is not as famous as classic emulsifiers like glyceryl stearate yet formulators appreciate its silky feel and low irritation profile so you will spot it in a growing number of cleansers, lotions and makeup products.

Overall safety data show very low toxicity, minimal skin penetration and rare reports of allergy. Most people can use products containing Peg-12 Diisostearate without concern, though performing a small patch test when trying any new skincare item is always a smart move.

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