What Is Peg-444 Pentaerythrityl Tetra(Glutaroylsuccinimide)?
Peg-444 Pentaerythrityl Tetra(Glutaroylsuccinimide) is a lab crafted ingredient that belongs to the large family of PEGs, or polyethylene glycols. At its core sits pentaerythritol, a small sugar-like molecule, that has been linked with four glutaroylsuccinimide groups and then capped with PEG “arms.” This design lets the ingredient hold water on its outer surface while the inner part stays oil friendly, making it a handy bridge between oily and watery parts of a formula.
PEGs have been used in cosmetics since the mid-20th century for their smoothing and moisture-binding skills. This particular PEG-444 version was developed more recently as chemists searched for milder options that leave skin feeling soft without a heavy or greasy afterfeel. It is produced by reacting pentaerythritol with glutaric anhydride and succinic anhydride, then attaching polyethylene glycol chains under controlled heat and pH. The final material is filtered and purified to remove unreacted residues so it meets cosmetic grade standards.
You can spot Peg-444 Pentaerythrityl Tetra(Glutaroylsuccinimide) in lightweight moisturizers, hydrating serums, sheet masks, soothing after-sun lotions and some BB or CC creams aimed at giving skin a smooth, conditioned finish. Formulators like it because it dissolves easily in water, thickens the product just a touch and boosts the skin’s soft feel.
Peg-444 Pentaerythrityl Tetra(Glutaroylsuccinimide)’s Cosmetic Benefits/Uses
Its main job in beauty products is straightforward yet valuable.
As a skin conditioning agent, it helps bind moisture to the surface of the skin, leaving it feeling soft, supple and lightly protected. By holding water in the upper layers it can reduce the look of dryness and flakiness and supports a smoother makeup application. It also improves the spreadability of the overall formula so the product glides on more evenly and comfortably.
Who Can Use Peg-444 Pentaerythrityl Tetra(Glutaroylsuccinimide)
This ingredient is considered friendly for most skin types including normal, dry, combination and oily skin because it is lightweight and does not leave a greasy residue. Sensitive skin usually tolerates it well since it lacks fragrance and common irritants, though extremely reactive or broken skin should approach any new ingredient with extra care.
Peg-444 Pentaerythrityl Tetra(Glutaroylsuccinimide) is synthetic and made without animal-derived raw materials, so it is suitable for vegans and vegetarians.
Current safety data suggest it is not known to penetrate deeply or enter the bloodstream, so products containing it are generally seen as safe for use during pregnancy and breastfeeding. That said this is not medical advice and anyone who is pregnant or nursing should confirm product choices with a qualified healthcare professional.
The molecule does not make skin more prone to sun damage and has no link to photosensitivity, so there is no special need for extra sun precautions beyond regular daily SPF use.
Potential Side Effects/Adverse Reactions
Reactions to the topical use of Peg-444 Pentaerythrityl Tetra(Glutaroylsuccinimide) can differ from person to person. The points below cover potential side effects only and most people will not experience them when the ingredient is used correctly in a well-formulated product.
- Mild redness or stinging in individuals with very sensitive or compromised skin
- Temporary dryness if combined with a high level of alcohol or other dehydrating ingredients in the same formula
- Contact dermatitis in rare cases of individual allergy to polyethylene glycols
- Eye irritation if the product accidentally gets into the eyes
If any irritation or discomfort occurs discontinue use and consult a healthcare professional if symptoms persist.
Comedogenic Rating
Rating: 1 out of 5
Peg-444 Pentaerythrityl Tetra(Glutaroylsuccinimide) has a very low chance of clogging pores because its large, water-loving structure sits on the skin surface and rinses away easily. It does not create a heavy, waxy film that can trap oil and dead cells, which is why it earns a score of 1 rather than 0. A handful of people may still break out if their skin reacts to any PEG, so the rating is not zero.
Most people who struggle with acne or frequent breakouts should find this ingredient suitable in everyday products.
Keep in mind the final formula matters: if Peg-444 Pentaerythrityl Tetra(Glutaroylsuccinimide) is blended with rich plant oils or butters, the overall product could still feel heavy on very oily skin.
Summary
Peg-444 Pentaerythrityl Tetra(Glutaroylsuccinimide) works mainly as a skin-conditioning agent. Its mix of water-grabbing PEG chains and oil-friendly core lets it pull moisture to the skin’s surface while helping products spread in a silky, even layer. This gives a softer feel, smoother makeup wear and a quick-absorbing finish without greasiness.
The ingredient is quietly popular with formulators who want lightweight hydration, yet it is not a buzzword shoppers will likely spot on the front of a box. You will mostly meet it tucked into serums, lotions or masks aimed at comfortable moisture.
Current safety data show low irritation risk, minimal penetration and no links to serious health issues, so it is considered safe for daily use. Still, every skin is unique so it is smart to patch test any new product that contains Peg-444 Pentaerythrityl Tetra(Glutaroylsuccinimide) before applying it to the whole face.