Peg/Ppg-22/40 Dimethyl Ether: What Is It, Cosmetic Uses, Benefits & Side Effects

Curious about this ingredient? In this article we're explaining exactly what it is and why it's used within cosmetic formulations.
Updated on: July 1, 2025
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We verify all information on this page using publicly available nomenclature standards from The Personal Care Products Council (PCPC), the European Commission's CosIng database and documentation provided directly by ingredient manufacturers. Our analysis is based on technical data from these sources to ensure accuracy and reliability.

What Is Peg/Ppg-22/40 Dimethyl Ether?

Peg/Ppg-22/40 Dimethyl Ether is a synthetic liquid ingredient created by linking together two kinds of repeating units known as ethylene oxide and propylene oxide, then capping the chain with dimethyl ether. The numbers 22 and 40 refer to the average ratio of those two blocks, which gives the material a balanced water-loving and oil-loving profile. This balance makes it highly versatile in personal care formulas.

The use of polyether compounds like this one took off in the late 1970s when formulators were looking for gentler alternatives to heavy mineral oils and drying alcohols. Advances in controlled polymerization allowed chemists to fine-tune the length of each block, resulting in ingredients that soften skin without greasiness. Peg/Ppg-22/40 Dimethyl Ether emerged from this wave of innovation and has been adopted by many global brands.

Manufacturing begins with propylene oxide and ethylene oxide derived from petroleum or natural gas. These monomers are reacted in a closed reactor under heat and pressure while a catalyst guides the alternating addition of each block. Once the desired chain length is reached, dimethyl ether caps the ends to stabilize the molecule and reduce reactivity. The finished product is then purified, tested for safety and supplied as a clear odorless fluid.

You will most often find Peg/Ppg-22/40 Dimethyl Ether in lightweight moisturizers, anti-aging serums, sheet masks, aftershave balms, sunscreens and rinse-off cleansers where a smooth non-tacky feel is valued.

Peg/Ppg-22/40 Dimethyl Ether’s Cosmetic Benefits/Uses

This ingredient is prized for one primary role: skin conditioning. Its dual affinity for water and oil allows it to glide effortlessly over the skin, forming a soft breathable layer that leaves the surface feeling silky yet non-oily. By improving spreadability it helps other active ingredients distribute evenly so a formula can deliver consistent results. It also reduces the white cast or streaking sometimes seen with mineral sunscreens and enhances the pleasant slip of gels and lotions.

Who Can Use Peg/Ppg-22/40 Dimethyl Ether

This conditioning agent is generally well tolerated by all skin types. Its light non greasy texture makes it a good option for oily and combination skin, while its ability to soften and smooth benefits normal and dry skin. Sensitive skin users typically do not report issues because the molecule is non reactive and fragrance free.

Peg/Ppg-22/40 Dimethyl Ether is synthesized entirely from petrochemical feedstocks and contains no animal derived materials, so it is suitable for vegans and vegetarians.

No data suggest that the ingredient interferes with pregnancy or breastfeeding when used topically in cosmetic amounts. This is not medical advice and anyone who is pregnant or nursing should check with a healthcare professional before starting new skincare products just to be safe.

The ingredient does not cause photosensitivity and can be used in daytime products alongside sunscreen without raising the risk of sunburn.

Potential Side Effects/Adverse Reactions

Reactions to Peg/Ppg-22/40 Dimethyl Ether vary from person to person. The effects listed below are possible but uncommon when the ingredient is used at the low concentrations typical in cosmetics.

  • Mild stinging or burning in individuals with very compromised skin barriers
  • Transient redness that resolves shortly after application
  • Contact dermatitis in rare cases of specific ingredient sensitivity
  • Eye irritation if a product containing the ingredient is accidentally rubbed into the eyes

If any discomfort or irritation occurs discontinue use and seek medical advice if symptoms persist.

Comedogenic Rating

Rating: 1 out of 5. Peg/Ppg-22/40 Dimethyl Ether is highly water soluble and leaves minimal residue on the skin, so it is very unlikely to clog pores. Its lightweight structure sits on the surface just long enough to boost softness then either absorbs or rinses away easily. Unlike heavier plant oils or waxes it does not occlude follicles or trap sebum.

Because of this low score the ingredient is generally considered suitable for people prone to acne or breakouts.

No known interactions increase its comedogenicity, and it does not appear to worsen acne medications or exfoliating routines.

Summary

Peg/Ppg-22/40 Dimethyl Ether is a synthetic polyether that serves mainly as a skin conditioning agent, giving formulas a silky glide and helping active ingredients spread evenly. Its balanced water loving and oil loving blocks let it soften the skin without heaviness or greasy afterfeel.

While not as famous as hyaluronic acid or glycerin it is a quiet workhorse found in a wide range of lotions, serums, sunscreens and cleansers where a weightless finish is desired.

Current safety data show it is low risk for irritation, non photosensitising and virtually non comedogenic. Still, skin can be unpredictable so it is smart to patch test any new product that contains this ingredient before full use.

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