What Is Pichia R-Sh-Polypeptide-19 Ferment Extract Filtrate?
Pichia R-Sh-Polypeptide-19 Ferment Extract Filtrate is a skin care ingredient that comes from the yeast Pichia pastoris. During a controlled fermentation process, this yeast produces sh-Polypeptide-19, a short chain of amino acids designed to mimic signals naturally found in skin. Once fermentation is complete, the mixture is filtered to remove the yeast cells, leaving a clear filtrate rich in the peptide along with helpful by-products such as amino acids, vitamins and sugars.
The use of fermented ingredients in beauty formulas has grown over the past decade thanks to advances in biotechnology. Brands were looking for gentler, more sustainable ways to deliver active peptides without animal sources, and Pichia pastoris offered a cost-effective platform. As peptide research expanded, sh-Polypeptide-19 was identified for its soothing and conditioning potential, leading formulators to include this filtrate in modern products.
Manufacturing starts by inserting the genetic blueprint for sh-Polypeptide-19 into the Pichia yeast. The yeast is then cultivated in nutrient-rich tanks where it secretes the peptide into the surrounding liquid. After fermentation, the liquid is clarified, filtered and sometimes concentrated to create a stable, water-based ingredient that blends easily into cosmetics.
You will most often find Pichia R-Sh-Polypeptide-19 Ferment Extract Filtrate in hydrating serums, anti-aging creams, sheet masks, soothing lotions and post-treatment balms where a lightweight, calming boost is desired.
Pichia R-Sh-Polypeptide-19 Ferment Extract Filtrate’s Cosmetic Benefits/Uses
In formulas, this ferment filtrate works in several helpful ways:
- Skin conditioning: The peptide content supports a smoother, softer feel while the natural sugars and amino acids help skin look fresh and well cared for
- Emollient: It forms a thin, breathable layer that helps trap moisture, reducing dryness and rough patches without feeling heavy
- Skin protecting: By reinforcing the surface barrier, it helps defend against daily irritants and environmental stress so skin stays comfortable
Who Can Use Pichia R-Sh-Polypeptide-19 Ferment Extract Filtrate
This ferment filtrate is generally suitable for all skin types including dry, oily, combination, sensitive and mature skin because it is lightweight, water based and non occlusive. People with extremely reactive skin or a known yeast allergy should proceed carefully since the ingredient is produced from Pichia pastoris, a type of yeast.
The material is produced through biotechnology using yeast so no animal derived material is involved, making it appropriate for vegans and vegetarians.
Current research shows no specific risks for women who are pregnant or breastfeeding when using this ingredient topically. Still, this is not medical advice and anyone who is pregnant or nursing should review any skincare routine with a qualified health professional just to be safe.
The filtrate does not make skin more sensitive to sunlight and it plays nicely with most other cosmetic actives. No special timing or layering rules are required.
Potential Side Effects/Adverse Reactions
Side effects and reactions to topical Pichia R-Sh-Polypeptide-19 Ferment Extract Filtrate can vary from person to person. The points below outline potential issues yet most users will not experience them when the ingredient is properly formulated and used as directed.
- Mild redness or warmth
- Temporary stinging on highly compromised skin
- Itchiness or rash in individuals with yeast sensitivities
- Rare breakouts if combined with very occlusive bases on acne prone skin
- Allergic contact dermatitis in the case of a true peptide allergy
If you notice persistent discomfort stop using the product and consult a healthcare professional or dermatologist
Comedogenic Rating
Rating: 0
Pichia R-Sh-Polypeptide-19 Ferment Extract Filtrate is a water based peptide blend with virtually no oils or fatty acids that could clog pores. The lightweight liquid absorbs quickly, leaves no residue and does not interfere with normal sebum flow, which is why it sits at the bottom of the comedogenic scale.
Suitable for acne prone or breakout prone skin.
Because the ingredient is usually paired with other low clogging materials in serums and gels its overall pore blocking risk stays very low as long as the finished formula is not loaded with heavy waxes or butters.
Summary
Pichia R-Sh-Polypeptide-19 Ferment Extract Filtrate conditions skin, softens rough patches and supports the protective barrier thanks to its mix of sh-Polypeptide-19, natural amino acids, sugars and vitamins created during fermentation. The peptide sends calming signals that help skin feel smoother while the supporting nutrients attract and hold water, giving an emollient yet weightless finish.
Although not as famous as collagen or niacinamide the ingredient is gaining quiet popularity in modern K beauty inspired formulas and niche soothing serums because brands value its vegan origin and gentle profile.
Current data shows it is well tolerated with minimal risk of irritation when used as directed. Still, everyone’s skin is unique so it is wise to patch test any new product containing this ferment filtrate before fully adding it to your routine.