Polyglutamic Acid: What Is It, Cosmetic Uses, Benefits & Side Effects

Curious about this ingredient? In this article we're explaining exactly what it is and why it's used within cosmetic formulations.
Updated on: July 1, 2025
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We verify all information on this page using publicly available nomenclature standards from The Personal Care Products Council (PCPC), the European Commission's CosIng database and documentation provided directly by ingredient manufacturers. Our analysis is based on technical data from these sources to ensure accuracy and reliability.

What Is Polyglutamic Acid?

Polyglutamic acid is a large chain of the amino acid glutamic acid that forms a clear, water-soluble polymer. Most commercial material is produced by fermenting Bacillus subtilis bacteria that naturally thrive on boiled soybeans, the same process that gives the Japanese food natto its stringy texture. After fermentation the viscous broth is filtered, dried and milled into a fine powder or turned into a concentrated solution ready for cosmetic use.

The ingredient first gained attention in Japan where natto makers noticed its remarkable water-holding capacity. Researchers soon realized that this property could translate into long-lasting surface hydration for skin. Over the last two decades, refinements in fermentation and purification have made polyglutamic acid stable, odourless and easy to incorporate into modern skincare.

You will now find it in hydrating serums, sheet masks, lightweight gels, rich creams, eye treatments and even makeup primers aimed at improving moisture retention and skin smoothness.

Polyglutamic Acid’s Cosmetic Benefits/Uses

Formulators rely on polyglutamic acid primarily for its ability to condition the skin.

As a skin-conditioning agent, it attracts and binds large amounts of water while forming a breathable film on the surface. This dual action helps keep skin feeling soft, plump and flexible for longer periods than many traditional humectants. The film can also improve the silky glide of a product and enhance the performance of other active ingredients by reducing transepidermal water loss.

Who Can Use Polyglutamic Acid

Polyglutamic acid is generally suitable for all skin types including dry, oily, combination, sensitive and mature. Its ability to trap water on the surface helps dry or dehydrated complexions look plumper while its light, breathable film rarely feels heavy on oily or acne prone skin. Those with very oily skin who dislike any trace of slip may prefer formulas that use lower percentages of the polymer or pair it with oil-absorbing ingredients.

The ingredient is produced by fermenting plant-based substrates with Bacillus subtilis so it contains no animal-derived components, making it appropriate for vegans and vegetarians.

Current research and long consumer use suggest it is safe for people who are pregnant or breastfeeding. Still, this is not medical advice and anyone who is expecting or nursing should clear any new skincare product with a doctor just to be safe.

Polyglutamic acid does not increase photosensitivity so it can be applied morning or night without elevating the skin’s susceptibility to sunburn. It also layers well with common actives such as vitamin C, niacinamide and retinoids without destabilising them.

Potential Side Effects/Adverse Reactions

Responses to topical polyglutamic acid differ from person to person. The effects listed below are only potential issues and are unlikely to occur for the average user when the ingredient is properly formulated.

  • Mild redness or stinging on very sensitive skin
  • Transient stickiness or tight sensation, especially at high concentrations
  • Allergic contact dermatitis in rare cases
  • Breakouts if the finished formula also contains pore-clogging oils or waxes
  • Pilling or flaking when layered over certain silicones or heavy creams
  • Eye irritation if the product migrates into the eyes

If you experience any of these reactions discontinue use and consult a healthcare professional or dermatologist.

Comedogenic Rating

Rating: 0 / 5. Polyglutamic acid is a large, water-soluble molecule that sits on the skin surface, attracts moisture and then rinses away easily. Because it is not oily, waxy or able to penetrate and block pores it is considered non-comedogenic. In most finished formulas it actually feels lighter than many common humectants, making it suitable for people who are prone to acne or breakouts. If blemishes occur they are more likely caused by other ingredients in the product rather than the polymer itself.

Summary

Polyglutamic acid is a skin-conditioning humectant that pulls in water and forms a thin breathable film to keep that water from evaporating. This one-two punch leaves skin soft, plump and smooth for hours. The ingredient has gained attention as a next-gen hydrator, though it is still less famous than hyaluronic acid so you will mainly spot it in forward-thinking serums, masks and primers. Safety data and years of consumer use show it is well tolerated for nearly every skin type with very few reports of irritation. As with any new skincare ingredient it is smart to patch test a fresh formula on a small area before applying it to the entire face.

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