Polyglycerin-6: What Is It, Cosmetic Uses, Benefits & Side Effects

Curious about this ingredient? In this article we're explaining exactly what it is and why it's used within cosmetic formulations.
Updated on: July 1, 2025
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We verify all information on this page using publicly available nomenclature standards from The Personal Care Products Council (PCPC), the European Commission's CosIng database and documentation provided directly by ingredient manufacturers. Our analysis is based on technical data from these sources to ensure accuracy and reliability.

What Is Polyglycerin-6?

Polyglycerin-6, also called hexaglycerol, is a chain of six glycerin units linked together. Glycerin itself is a simple sugar alcohol that can be sourced from plant oils like soybean or coconut or from synthetic processes. By joining several glycerin molecules, chemists create a larger, water-loving compound that offers skin-friendly hydration with a lighter feel than straight glycerin.

The ingredient first appeared in cosmetics during the late 1990s when formulators searched for mild alternatives to petroleum-based moisturizers. Because it is built from renewable glycerin, Polyglycerin-6 fit the bill for brands aiming for cleaner labels and vegan claims.

Manufacturers make Polyglycerin-6 through a controlled heating process called condensation polymerization. Glycerin is gently heated in the presence of safe catalysts, causing the molecules to link end to end. The final syrup-like liquid is then purified and checked for quality before it heads to the lab bench.

You will spot Polyglycerin-6 in a variety of leave-on and rinse-off products. It shows up in lightweight moisturizers, hydrating serums, sheet masks, soothing after-sun gels, scalp treatments, gentle cleansers and even some hair conditioners where extra slip and moisture are desired.

Polyglycerin-6’s Cosmetic Benefits/Uses

In skin and hair formulas Polyglycerin-6 serves mainly as a humectant. Its many hydroxyl groups pull water from the air and bind it to the surface of the skin or hair. This action helps boost immediate hydration, softens rough spots, supports a plump look and can improve the spreadability of other ingredients in the mix.

Who Can Use Polyglycerin-6

Polyglycerin-6 is considered friendly for almost every skin type. Dry normal and combination skin appreciate its water-binding ability while oily and acne-prone skin benefit from its light feel that will not clog pores. Sensitive skin usually tolerates it well because it is free of fragrances and harsh solvents. There are no known skin types that must avoid Polyglycerin-6 unless an individual has a specific allergy to glycerin derivatives.

Because the ingredient is sourced from plant glycerin or produced synthetically without animal input it suits both vegetarians and vegans. No animal testing is required for its manufacture under current cosmetic regulations in many regions.

Current safety data show no issues for pregnant or breastfeeding women when Polyglycerin-6 is used topically in typical cosmetic amounts. This is not medical advice and anyone who is pregnant or nursing should review any skincare product with their doctor to be safe.

The ingredient does not cause photosensitivity so it will not make skin more prone to sunburn. It can be used day or night alone or layered with sunscreens and actives. There are no known interactions with common cosmetic actives such as retinoids vitamin C or exfoliating acids.

Potential Side Effects/Adverse Reactions

Individual responses to topical Polyglycerin-6 can vary. The following points outline potential side effects that could occur in rare cases. Most users will not experience these issues when the ingredient is formulated and used correctly.

  • Mild skin redness or irritation
  • Temporary stinging on very compromised or broken skin
  • Allergic contact dermatitis in people highly sensitive to glycerin-based compounds
  • In very low humidity settings a tight or dry feel if the product is not paired with an occlusive ingredient

If any uncomfortable reaction develops stop using the product and seek advice from a qualified health professional.

Comedogenic Rating

Rating: 0/5. Polyglycerin-6 is a large water-soluble molecule that stays on the skin surface and rinses away easily so it has almost no chance of blocking pores. Its structure is similar to glycerin, which is widely accepted as non-comedogenic. For these reasons it earns the lowest score possible and is generally considered safe for skin that breaks out.

Suitable for acne-prone users: Yes.

Because it draws in water, Polyglycerin-6 can even help thin out heavier creams and reduce the greasy feel that sometimes leads people to over-cleanse and irritate blemish-prone skin.

Summary

Polyglycerin-6 is mainly a humectant that grabs moisture from the air and anchors it to the skin or hair surface. This boosts hydration, smooths rough patches and helps other ingredients spread more evenly. Its lightweight feel and plant-based origin make it a popular pick in modern gel creams, serums and rinse-off products, though it has not reached the household-name status of classic glycerin.

Current data show it to be very safe for topical use with a low risk of irritation or pore clogging. As with any new cosmetic, give your skin a quick patch test first to be sure it agrees with you.

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