Polyglyceryl-4 Isostearate/Laurate: What Is It, Cosmetic Uses, Benefits & Side Effects

Curious about this ingredient? In this article we're explaining exactly what it is and why it's used within cosmetic formulations.
Updated on: July 1, 2025
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We verify all information on this page using publicly available nomenclature standards from The Personal Care Products Council (PCPC), the European Commission's CosIng database and documentation provided directly by ingredient manufacturers. Our analysis is based on technical data from these sources to ensure accuracy and reliability.

What Is Polyglyceryl-4 Isostearate/Laurate?

Polyglyceryl-4 Isostearate/Laurate is an ester made by linking a plant derived molecule called tetraglycerol with two fatty acids, isostearic acid and lauric acid, that come from natural oils such as coconut or palm. The result is a mild, oil loving ingredient that helps water and oil mix in a stable way.

The cosmetic world began looking at polyglyceryl esters in the late 1990s as brands searched for alternatives to traditional petroleum based surfactants. Because its building blocks come from renewable plant oils and glycerin, Polyglyceryl-4 Isostearate/Laurate fit the push for more eco friendly formulas and quickly found a place in natural skin care lines.

Manufacturing starts with glycerin that is heated to link four of its molecules into tetraglycerol. This backbone is then reacted with a carefully measured mix of isostearic and lauric acids under controlled heat. The reaction bonds the fatty acids to the glycerol chain, creating a smooth liquid or soft paste that is easy to blend into creams and lotions.

You will most often see Polyglyceryl-4 Isostearate/Laurate in fluid foundations, tinted moisturizers, sunscreens, rich face lotions, sheet mask essences and makeup removers. Anywhere a formulator needs oil and water to stay blended for a long shelf life, this ingredient is a reliable choice.

Polyglyceryl-4 Isostearate/Laurate’s Cosmetic Benefits/Uses

Its main value to a formula comes from one key role.

As an emulsifying agent it binds oil and water into a uniform mixture, giving creams and lotions a smooth texture that spreads easily, prevents separation on the shelf and improves the delivery of both water soluble and oil soluble skin goodies.

Who Can Use Polyglyceryl-4 Isostearate/Laurate

This emulsifier is generally suitable for all skin types. Dry, normal and combination skin benefit from its light conditioning feel, while sensitive skin appreciates its mild nature and lack of fragrance. Those with very oily or acne prone skin usually tolerate it well because it is lightweight and has a low likelihood of clogging pores, though extremely blemish prone users may still prefer minimal oil-derived ingredients.

Because it is produced from plant glycerin plus fatty acids that come from coconut or palm, Polyglyceryl-4 Isostearate/Laurate is considered vegan and vegetarian friendly. No animal byproducts are used at any point in its manufacture.

Current safety data show no special concerns for women who are pregnant or breastfeeding when this ingredient is applied topically. It is not absorbed into the bloodstream at meaningful levels and is classed as non-toxic. That said, this is not medical advice and anyone who is expecting or nursing should confirm the suitability of a full product with their physician just to be safe.

The molecule does not make skin more sensitive to sunlight, so there is no increased risk of sunburn or photosensitivity when you use products containing it.

It works well alongside most common skincare actives and preservatives so there are no known ingredient compatibility issues worth noting.

Potential Side Effects/Adverse Reactions

Skin responses to Polyglyceryl-4 Isostearate/Laurate can vary from one person to the next. The points below list potential side effects yet these reactions are uncommon and most users will not experience them when the ingredient is used correctly in a professionally formulated product.

  • Mild skin irritation – very sensitive or compromised skin may feel slight stinging or redness right after application
  • Allergic contact dermatitis – a rare immune response that leads to itching, rash or swelling
  • Eye stinging – if a product containing the ingredient gets into the eyes it can cause temporary discomfort and tearing
  • Breakouts in highly acne prone skin – although low on the comedogenic scale, some individuals prone to clogged pores might see an uptick in blemishes

If you notice any of the above reactions discontinue use immediately and seek medical advice if symptoms persist or worsen.

Comedogenic Rating

Rating: 1 out of 5. Although it contains fatty acid parts, they are bound to a bulky polyglycerol backbone that keeps the molecule from nesting deep in pores. It spreads in a thin flexible film and rinses off easily, so it is unlikely to trap dead skin and sebum.

Most people who are prone to acne or breakouts can use products with Polyglyceryl-4 Isostearate/Laurate without trouble.

Keep in mind that any finished formula can feel heavier or lighter depending on the other oils and butters included. If a product contains several rich emollients the overall comedogenic potential may be higher than this single ingredient suggests.

Summary

Polyglyceryl-4 Isostearate/Laurate is a plant based emulsifier that helps oil and water mingle smoothly, giving creams and makeup a stable, velvety feel while staying gentle on skin. It does this by using a polyglycerol backbone that loves water paired with fatty acid tails that love oil, creating a bridge that locks the two phases together.

The ingredient is not as famous as classic emulsifiers like polysorbates, yet it is gaining steady popularity in green beauty and sensitive skin formulas thanks to its renewable sourcing and mild touch.

Current research labels it low risk for irritation or systemic toxicity, and real world use backs that up. Still, skin is personal so it is always smart to patch test any new product containing Polyglyceryl-4 Isostearate/Laurate before applying it to the whole face.

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