Polyglyceryl-5 Myristate: What Is It, Cosmetic Uses, Benefits & Side Effects

Curious about this ingredient? In this article we're explaining exactly what it is and why it's used within cosmetic formulations.
Updated on: July 1, 2025
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We verify all information on this page using publicly available nomenclature standards from The Personal Care Products Council (PCPC), the European Commission's CosIng database and documentation provided directly by ingredient manufacturers. Our analysis is based on technical data from these sources to ensure accuracy and reliability.

What Is Polyglyceryl-5 Myristate?

Polyglyceryl-5 Myristate is a plant derived ingredient created by joining five glycerin units with myristic acid, a fatty acid that naturally occurs in coconut and palm oils. The result is a mild, biodegradable molecule that acts as an oil-lover on one end and a water-lover on the other, letting it pull oil and water together smoothly. Chemists began exploring these polyglyceryl esters in the late 1980s as a gentler alternative to traditional petroleum based emulsifiers, and their popularity grew as brands looked for more skin friendly, eco conscious options.

The manufacturing process starts with glycerin that has been polymerized to form polyglycerin-5. This chain is then reacted with purified myristic acid under controlled heat and vacuum conditions to produce Polyglyceryl-5 Myristate. Because the raw materials can come from renewable vegetable sources and no harsh solvents are needed, the final ingredient fits well into clean beauty formulations.

You will most often spot Polyglyceryl-5 Myristate in lotions, creams, face masks, lightweight moisturizers, sunscreens, makeup removers and anti-aging serums where a balanced oil-in-water texture is key. It is also used in wipes and rinse-off cleansers to give a soft after feel without greasy residue.

Polyglyceryl-5 Myristate’s Cosmetic Benefits/Uses

This ingredient serves a single yet vital job in skincare and makeup formulas: it is an emulsifier. By holding oil and water together it ensures a stable, smooth product that feels pleasant on the skin, spreads evenly and delivers active ingredients where they are needed without separating over time.

Who Can Use Polyglyceryl-5 Myristate

Because it is a mild, nonionic emulsifier with a light skin feel Polyglyceryl-5 Myristate is generally suitable for dry, normal, combination and oily skin. Sensitive skin usually tolerates it well since it contains no fragrance or ethoxylated groups that often trigger stinging. Extremely acne-prone users may prefer to monitor how their skin responds, but the molecule itself is not considered highly occlusive so most people do not see clogged pores from it.

The raw materials come from vegetable glycerin and plant sourced myristic acid which makes the ingredient appropriate for vegans and vegetarians. No animal derivatives or animal testing are needed to produce it, a plus for cruelty-free shoppers.

Current cosmetic safety data show no reproductive risks from topical use, so products with Polyglyceryl-5 Myristate are typically viewed as safe for pregnant or breastfeeding women. This is not medical advice and anyone who is expecting or nursing should ask a healthcare professional before introducing new skincare just to be certain.

Polyglyceryl-5 Myristate does not absorb UV light or alter the way skin reacts to sun exposure, so it is not linked to photosensitivity. It also plays nicely with most active ingredients including acids, retinoids and mineral sunscreens, giving formulators flexibility without raising interaction concerns.

Potential Side Effects/Adverse Reactions

Responses to any cosmetic ingredient can differ from person to person. The effects listed below are possible yet uncommon when Polyglyceryl-5 Myristate is used in a well formulated product.

  • Mild redness or stinging in very sensitive skin
  • Contact dermatitis in individuals allergic to fatty acid derivatives
  • Transient eye irritation if the product is accidentally rubbed into the eyes
  • Rare clogging or comedone formation in users who are highly prone to acne

If you notice persistent irritation, breakouts or any unusual reaction stop using the product and consult a qualified medical professional.

Comedogenic Rating

Rating: 1 out of 5. While the myristic acid part of the molecule is a medium-chain fatty acid that could in theory obstruct pores, attaching it to a highly water-loving polyglycerin backbone keeps the whole ingredient largely water dispersible and less likely to linger in follicular openings. Real-world reports and formulation data show very few breakout complaints. Most acne-prone users can use it without trouble, though exceptionally reactive skin should still observe how it behaves. No additional factors such as heavy oil load or waxy texture push its pore-clogging potential higher, so it sits on the low end of the scale.

Summary

Polyglyceryl-5 Myristate is an emulsifier that ties oil and water together, giving creams, lotions and cleansers a smooth, stable feel while helping active ingredients distribute evenly. It does this by pairing a fatty acid tail that grabs oils with a polyglycerin head that attracts water, letting the two phases mix and stay mixed.

The ingredient enjoys steady but not blockbuster popularity. Natural leaning and clean beauty brands favor it for its plant origin, mildness and biodegradability, while some mainstream lines still rely on older petroleum-based emulsifiers because they are cheaper or more familiar.

Current safety reviews rate Polyglyceryl-5 Myristate as low risk for irritation, sensitization or systemic toxicity, making it broadly safe for daily cosmetic use. As with any new skincare ingredient it is wise to patch test a fresh product first to confirm personal tolerance.

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