Polyquaternium-112: What Is It, Cosmetic Uses, Benefits & Side Effects

Curious about this ingredient? In this article we're explaining exactly what it is and why it's used within cosmetic formulations.
Updated on: July 1, 2025
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We verify all information on this page using publicly available nomenclature standards from The Personal Care Products Council (PCPC), the European Commission's CosIng database and documentation provided directly by ingredient manufacturers. Our analysis is based on technical data from these sources to ensure accuracy and reliability.

What Is Polyquaternium-112?

Polyquaternium-112 is a man-made conditioning polymer created by linking smaller quaternary ammonium units into a long chain. These units carry a positive charge, which is why the ingredient is grouped under the “polyquaternium” family often seen on hair and skin care labels. The raw materials usually start with simple petrochemical or plant-derived alcohols that are reacted with ammonium compounds. Through controlled heating and mixing, chemists build the final high-molecular-weight polymer that dissolves easily in water.

The cosmetic world began using quaternary polymers in the 1970s to tackle frizz and static in hair products. Over time, formulators tweaked the chain length and charge density to create versions like Polyquaternium-112 that give stronger hold without a heavy feel. Today the ingredient appears in many rinse-off and leave-on products such as shampoos, conditioners, styling gels, mousses, hair sprays, detangling mists, smoothing serums and even some skin primers that benefit from a light film on the surface.

Polyquaternium-112’s Cosmetic Benefits/Uses

In formulas, Polyquaternium-112 steps in as a multitasker that improves both how a product feels and how it performs on hair or skin.

  • Antistatic: The positive charges on the polymer neutralize negative charges that build up on hair strands during washing or brushing. This tames flyaways and makes hair easier to style.
  • Film Forming: It lays down a thin, invisible layer that smooths the hair cuticle or skin surface. This film helps lock in moisture and gives a soft, silky touch without greasiness.
  • Hair Fixing: Thanks to its flexible yet resilient nature, the polymer provides light to medium hold in styling products. It helps set curls, maintain volume and keep styles in place throughout the day.

Who Can Use Polyquaternium-112

Polyquaternium-112 is generally well tolerated by all skin and hair types, including normal, oily, combination and dry. Because it forms a lightweight water-soluble film rather than an occlusive layer, it rarely weighs down fine hair or clogs pores on the scalp or skin. People with very sensitive or compromised skin might still prefer low concentrations until they know how their skin responds.

The ingredient is produced through synthetic reactions that do not rely on animal by-products, so it is typically considered suitable for both vegetarians and vegans. Cruelty-free status, however, depends on the finished brand’s individual policies and certifications.

Pregnant or breastfeeding individuals can usually use products containing Polyquaternium-112 since the large molecule remains on the surface and is not expected to enter the bloodstream. This is not medical advice; anyone who is pregnant or nursing should review their routine with a healthcare professional for personalized guidance.

Polyquaternium-112 does not make skin more sensitive to sunlight and has no known phototoxic effects. It is also color-safe for dyed hair and is compatible with most common ingredients found in shampoos, conditioners and styling products.

Potential Side Effects/Adverse Reactions

Responses to topical Polyquaternium-112 can vary from person to person. The effects listed below are only potential issues and are unlikely to be experienced by most users when the ingredient is used at appropriate levels in a well formulated product.

  • Mild skin or scalp irritation – itching, dryness or slight redness can occur in those with very sensitive skin
  • Allergic contact dermatitis – rare cases of localized swelling or rash have been reported when an individual is specifically allergic to quaternary ammonium compounds
  • Product buildup – heavy or frequent application without proper cleansing may leave hair feeling coated or limp
  • Eye irritation – stinging or watering if the product accidentally gets into the eyes

Discontinue use and consult a qualified healthcare provider if you experience any persistent discomfort or adverse reaction while using products that contain Polyquaternium-112.

Comedogenic Rating

Rating: 1 (very low)

Polyquaternium-112 is a large, water-soluble molecule that sits on the surface then rinses away easily. It does not penetrate pores or leave a heavy, oily residue, which is why its potential to clog pores is minimal. For most users, including those prone to acne or breakouts, this ingredient is considered safe and unlikely to trigger comedones. People using very rich leave-in formulas alongside it should cleanse regularly to avoid any buildup that could indirectly contribute to congestion.

Summary

Polyquaternium-112 works as an antistatic agent, a film former and a light hair fixer. Its positively charged chain binds to negatively charged hair or skin, creating an even, breathable film that smooths cuticles, controls flyaways and delivers flexible hold without a greasy feel. While not as famous as silicone classics or the older polyquaternium-10, it shows up in a fair number of modern shampoos, conditioners and styling sprays because formulators appreciate its lightweight performance. Overall safety is high, with only rare reports of irritation or allergy. As with any new cosmetic, do a quick patch test the first time you try a product containing Polyquaternium-112 just to be sure it agrees with your skin or scalp.

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