Polyquaternium-22: What Is It, Cosmetic Uses, Benefits & Side Effects

Curious about this ingredient? In this article we're explaining exactly what it is and why it's used within cosmetic formulations.
Updated on: July 1, 2025
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We verify all information on this page using publicly available nomenclature standards from The Personal Care Products Council (PCPC), the European Commission's CosIng database and documentation provided directly by ingredient manufacturers. Our analysis is based on technical data from these sources to ensure accuracy and reliability.

What Is Polyquaternium-22?

Polyquaternium-22 is a man-made polymer created by linking together two building blocks: dimethyl diallyl ammonium chloride and acrylic acid. The result is a clear water-soluble substance that carries a positive charge. Because of this charge, it is drawn to the negative sites on hair and skin, allowing it to coat surfaces evenly.

The ingredient first appeared in the late 1970s when chemists were looking for safer, longer-lasting alternatives to older conditioning agents that could weigh hair down. By tweaking the ratio of its two starting materials, they found a formula that offered a soft touch without heaviness or stickiness. Commercial production begins with purified water in a reaction vessel. The two monomers are added along with a gentle catalyst, then heated until they link into long chains. The finished solution is filtered, cooled and standardized for use in cosmetics.

Today Polyquaternium-22 shows up in a wide range of rinse-off and leave-on products. You will often spot it in shampoos, conditioners, styling gels, hair masks, body washes, facial cleansers, spray-on detanglers and some lightweight moisturizers. Brands favor it because a small amount gives noticeable smoothing and helps other ingredients spread more evenly.

Polyquaternium-22’s Cosmetic Benefits/Uses

Below are the main ways Polyquaternium-22 improves the feel and performance of beauty products

  • Antistatic: Its positive charge neutralizes static electricity on hair strands which reduces frizz flyaways and breakage. This makes styling easier and helps hairstyles stay neat longer.
  • Film Forming: It creates a thin flexible coating that locks in moisture smooths rough cuticles and adds light hold. On skin this film can boost softness and help active ingredients stay in place.

Who Can Use Polyquaternium-22

Because Polyquaternium-22 is water soluble and lightly conditioning it suits most skin and hair types including oily dry sensitive and combination. Its lightweight film does not normally clog pores so acne-prone users typically tolerate it well. Those with extremely sensitive or allergy-prone skin should still check ingredient lists for other possible irritants in the formula rather than the polymer itself.

The compound is synthesized entirely from petrochemical or mineral sources so it is suitable for vegans and vegetarians. No animal-derived matter is used during manufacturing nor is animal testing required in regions that ban it.

Current safety data show no specific risks for pregnant or breastfeeding women when Polyquaternium-22 is applied topically in rinse-off or leave-on products. This is not medical advice and anyone who is pregnant or nursing should consult a healthcare provider before introducing new personal care items just to be safe.

Polyquaternium-22 does not absorb UV light and is not known to increase photosensitivity. It also has no documented interactions with common active ingredients such as retinoids or alpha hydroxy acids so it can be layered without special precautions.

Potential Side Effects/Adverse Reactions

Individual reactions to topical Polyquaternium-22 vary. The points below outline possible but uncommon side effects when the ingredient is properly formulated and used as directed most people experience none of these issues.

  • Mild skin redness or itching
  • Transient stinging if applied to broken or freshly shaved skin
  • Eye irritation if product accidentally gets into eyes
  • Build-up on hair from overuse leading to a weighed-down feel
  • Rare allergic contact dermatitis

If any discomfort or unusual reaction occurs discontinue use of the product and seek advice from a healthcare professional

Comedogenic Rating

Rating: 0 / 5

Polyquaternium-22 is highly water soluble and forms a very thin breathable film that rinses away easily, so it does not trap oil or debris inside pores. It also lacks fatty or waxy components that normally raise comedogenicity scores. For these reasons it is considered non-comedogenic and is generally suitable for people who are prone to acne or breakouts.

Because it is cationic, it binds mostly to the outer surface of hair and skin and is removed with normal cleansing, which further reduces any risk of pore blockage. No studies or anecdotal reports have connected Polyquaternium-22 to increased comedones or acne flare-ups.

Summary

Polyquaternium-22 delivers two key benefits in cosmetics: antistatic action and light film formation. Its positive charge neutralizes static electricity on hair while its flexible film smooths cuticles locks in moisture and gives gentle hold. On skin that same film can enhance softness and help active ingredients stay where they are applied.

The polymer is popular in modern shampoos conditioners gels and body washes because formulators can achieve noticeable conditioning with a low dose and without heaviness. It is not as famous as silicone giants like dimethicone but it has carved out a steady place in daily rinse-off and leave-on products thanks to its clean feel and versatility.

Current safety data rate it as low risk for irritation or allergy in the percentages used in cosmetics. Nevertheless skin chemistry is personal so it is wise to patch test any new product that contains Polyquaternium-22 before regular use.

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