Quaternium-15: What Is It, Cosmetic Uses, Benefits & Side Effects

Curious about this ingredient? In this article we're explaining exactly what it is and why it's used within cosmetic formulations.
Updated on: June 30, 2025
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We verify all information on this page using publicly available nomenclature standards from The Personal Care Products Council (PCPC), the European Commission's CosIng database and documentation provided directly by ingredient manufacturers. Our analysis is based on technical data from these sources to ensure accuracy and reliability.

What Is Quaternium-15?

Quaternium-15 is a synthetic compound officially known as methenamine 3-chloroallylochloride. Chemists create it by combining methenamine, a substance made from ammonia and formaldehyde, with chlorinated compounds. The result is a quaternary ammonium salt that dissolves well in water and releases small amounts of formaldehyde over time. This slow release is what makes the ingredient valuable for keeping products fresh.

The cosmetic industry began using Quaternium-15 in the 1950s when formulators were searching for preservatives that could stop bacteria and mold yet remain stable in creams and lotions. Because it works in both oil-and water-based formulas and performs well over a wide pH range it quickly became a go-to option for large-scale manufacturing.

Today you can spot Quaternium-15 in many rinse-off and leave-on products such as shampoos, conditioners, facial cleansers, sheet masks, moisturizers, sunscreens and styling gels where its preserving power helps extend shelf life and keep textures smooth.

Quaternium-15’s Cosmetic Benefits/Uses

In skincare and haircare formulas Quaternium-15 plays two main roles that focus on product safety and stability

  • Antimicrobial: It reduces the growth of bacteria, yeast and mold inside the bottle which keeps the product sanitary from the first use to the last
  • Preservative: By safeguarding the formula against spoilage it helps maintain the product’s color, scent and effectiveness for its entire shelf life so users get consistent results every time

Who Can Use Quaternium-15

Quaternium-15 is a preservative that generally suits normal, oily and combination skin because these skin types are less prone to sensitivity. People with very dry or compromised skin, especially those who already struggle with eczema or rosacea, may find it less suitable since they can be more reactive to preservatives that release trace amounts of formaldehyde.

The ingredient is synthetically produced so it contains no animal-derived substances, which makes it acceptable for vegans and vegetarians. Whether the finished product is cruelty free depends on the brand’s overall policy rather than on Quaternium-15 itself.

Pregnant or breastfeeding women can technically use products containing this preservative because there is no evidence of systemic absorption at levels used in cosmetics. That said this is not medical advice and anyone who is pregnant or nursing should check with a healthcare professional before adding new products to their routine.

Quaternium-15 does not make skin more sensitive to sunlight and it has no known interactions with UV exposure. It is also compatible with most other common skincare and haircare ingredients so formulators can pair it with acids, retinoids or antioxidants without stability issues.

Potential Side Effects/Adverse Reactions

Side effects from topical Quaternium-15 vary from person to person. The points below outline potential reactions yet most users will not encounter these issues when the ingredient is used correctly in a well-formulated product.

  • Contact dermatitis Persistent redness, itching or rash at the site of application can occur in individuals who develop an allergy or sensitivity
  • Eye irritation Stinging or watering if the product accidentally gets into the eyes, more common with shampoos and cleansers
  • Skin irritation on compromised barriers Heightened burning or discomfort on already damaged or freshly shaved skin
  • Respiratory irritation from aerosols Coughing or throat discomfort when inhaled from spray products in poorly ventilated spaces
  • Allergic sensitization over time Rare cases where repeated exposure leads to a delayed allergic response even if initial use was problem free

If you experience any of the above reactions discontinue use and seek guidance from a qualified healthcare professional or dermatologist.

Comedogenic Rating

Rating: 0/5 (non-comedogenic)

Quaternium-15 is water soluble and used at very low concentrations so it does not leave an occlusive film that could trap oil or debris inside pores. Because it functions strictly as a preservative rather than an emollient or thickener it has virtually no potential to clog skin.

That means the ingredient is generally suitable for people who are prone to acne or breakouts.

Bonus tip: most preservatives share a similarly low comedogenic profile since they are present in tiny amounts and rarely add texture that sits on the skin.

Summary

Quaternium-15 is included in cosmetics for two key reasons: it keeps formulas free from bacteria, yeast and mold while helping products maintain their color scent and performance. It pulls this off by slowly releasing trace formaldehyde which disrupts microbial growth across a broad pH range.

Once a staple in many mainstream shampoos and lotions its popularity has dipped as brands explore alternative preservatives that do not release formaldehyde. Even so you will still find it in some haircare and skincare lines because it is cost effective and reliable.

When used within current regulatory limits Quaternium-15 is considered safe for topical use, though people with very sensitive or compromised skin may prefer to avoid it. As with any new product a simple patch test on a small area lets you check for personal irritation before applying it more widely.

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