What Is Quaternium-76 Hydrolyzed Collagen?
Quaternium-76 Hydrolyzed Collagen is a specialized form of collagen that has been broken down into smaller protein fragments, then chemically modified with a quaternary ammonium group. The hydrolysis step makes the collagen pieces small enough to sit smoothly on hair or skin, while the “quaternium” part gives each fragment a positive charge. Because hair and skin surfaces tend to carry a slight negative charge, this positive charge helps the ingredient cling where it is applied instead of rinsing away.
This technology first gained traction in the late 1980s when formulators looked for gentler alternatives to harsh conditioning agents. By combining naturally sourced collagen—often taken from fish or bovine by-products—with modern quaternization methods, chemists created a conditioner that feels soft and lightweight. Production starts with purified collagen, which is enzymatically or acid-treated to form small peptides. These peptides are then reacted with a quaternary ammonium compound, washed, and dried into a fine powder or liquid concentrate for use in labs.
You will most often spot Quaternium-76 Hydrolyzed Collagen in rinse-off and leave-in hair conditioners, shampoos, masks, and styling creams that promise smoothness or anti-frizz benefits. It also turns up in skin-care products like lightweight lotions, firming serums, sheet masks, and after-sun gels where a silky finish is desired.
Quaternium-76 Hydrolyzed Collagen’s Cosmetic Benefits/Uses
Below are the main ways this ingredient improves personal-care formulas
- Antistatic: The positive charge neutralizes static electricity on hair strands, reducing flyaways and making styling easier
- Hair Conditioning: Forms a thin, breathable film that smooths the cuticle, boosts shine, and helps hair feel softer without heaviness
- Skin Conditioning: Creates a light, silky layer that improves skin feel, adds a hint of moisture, and can make the surface appear more even and plump
Who Can Use Quaternium-76 Hydrolyzed Collagen
Thanks to its lightweight film-forming nature, Quaternium-76 Hydrolyzed Collagen suits most skin and hair types, including dry, normal and combination. Oily or acne-prone users generally tolerate it as it does not clog pores or leave a greasy residue. Those with very sensitive or protein-reactive skin should approach with caution because, although uncommon, quaternary compounds and animal-derived peptides can occasionally provoke irritation.
The ingredient is not considered vegan or vegetarian friendly because collagen is traditionally sourced from animal by-products such as fish skin or bovine hide. If plant-derived alternatives are used, the label will clearly state so, but standard Quaternium-76 Hydrolyzed Collagen remains animal based.
No specific warnings exist for pregnant or breastfeeding women regarding topical use of this ingredient, and it is widely regarded as safe in cosmetics. Still, this is not medical advice, and anyone who is expecting or nursing should discuss new personal-care products with a healthcare professional before adding them to a routine.
Quaternium-76 Hydrolyzed Collagen is non-photosensitizing, so it will not make skin more prone to sunburn. It is also compatible with most common skincare and haircare actives, meaning it rarely causes formula conflicts.
Potential Side Effects/Adverse Reactions
Responses to Quaternium-76 Hydrolyzed Collagen vary from person to person. The effects listed below are only potential issues and are not likely to occur for the average user when the ingredient is properly formulated in a finished product.
- Mild skin redness or stinging in very sensitive individuals
- Allergic contact dermatitis in people with existing collagen or quaternary ammonium sensitivities
- Scalp buildup or limp hair if used in excess or not rinsed thoroughly
- Eye irritation if the product accidentally gets into the eyes during application or rinsing
- Reaction in those with known fish or bovine protein allergies, depending on the collagen source
If any irritation, itching or other unwanted reaction develops, stop using the product and consult a qualified healthcare professional for guidance.
Comedogenic Rating
Rating: 1/5
Quaternium-76 Hydrolyzed Collagen is water-soluble and forms a light breathable film rather than a heavy oily layer, so it is unlikely to clog pores. Its positive charge keeps it on the surface of skin or hair which limits penetration into follicles and helps it rinse away cleanly.
Generally considered suitable for acne-prone or breakout-prone users.
The overall likelihood of breakouts still depends on the full product formula. If the collagen is paired with rich butters or occlusive oils the finished product could feel heavier even though the collagen itself is low risk.
Summary
Quaternium-76 Hydrolyzed Collagen works as an antistatic agent, hair conditioner and skin conditioner. Hydrolyzed peptides smooth cuticles and soften skin while the quaternary ammonium charge helps the ingredient stay put, tame flyaways and add a silky touch.
Moderately popular in shampoos conditioners and lightweight lotions, it offers a softer alternative to silicones yet is less common than mainstream conditioning agents.
It is generally safe with low irritation potential. Still it is smart to patch test any new product containing Quaternium-76 Hydrolyzed Collagen to check for personal sensitivities, especially for those with protein or quaternary ammonium allergies.